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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T489","span":{"begin":28,"end":37},"obj":"Body_part"},{"id":"T490","span":{"begin":102,"end":105},"obj":"Body_part"},{"id":"T491","span":{"begin":113,"end":116},"obj":"Body_part"},{"id":"T492","span":{"begin":317,"end":326},"obj":"Body_part"}],"attributes":[{"id":"A489","pred":"fma_id","subj":"T489","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A490","pred":"fma_id","subj":"T490","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A491","pred":"fma_id","subj":"T491","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A492","pred":"fma_id","subj":"T492","obj":"http://purl.org/sig/ont/fma/fma68923"},{"subj":"T489","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T490","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T491","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T492","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T98","span":{"begin":113,"end":116},"obj":"Body_part"}],"attributes":[{"id":"A98","pred":"uberon_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T133","span":{"begin":362,"end":374},"obj":"Disease"}],"attributes":[{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T586","span":{"begin":28,"end":37},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T587","span":{"begin":113,"end":116},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T588","span":{"begin":113,"end":116},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T589","span":{"begin":113,"end":116},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T590","span":{"begin":317,"end":326},"obj":"http://purl.obolibrary.org/obo/CL_0000129"}],"attributes":[{"subj":"T586","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T587","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T588","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T589","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T590","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1791","span":{"begin":102,"end":105},"obj":"Species"},{"id":"1792","span":{"begin":362,"end":374},"obj":"Disease"},{"id":"1793","span":{"begin":379,"end":391},"obj":"Disease"}],"attributes":[{"id":"A1791","pred":"tao:has_database_id","subj":"1791","obj":"Tax:12721"},{"id":"A1792","pred":"tao:has_database_id","subj":"1792","obj":"MESH:D007249"},{"id":"A1793","pred":"tao:has_database_id","subj":"1793","obj":"MESH:D064420"},{"subj":"1791","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1792","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1793","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T84","span":{"begin":362,"end":374},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T84","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T714","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"T715","span":{"begin":206,"end":406},"obj":"Sentence"},{"id":"T716","span":{"begin":407,"end":419},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T714","pred":"source","obj":"LitCovid-sentences"},{"subj":"T715","pred":"source","obj":"LitCovid-sentences"},{"subj":"T716","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32876803-16260386-62958099","span":{"begin":407,"end":411},"obj":"16260386"},{"id":"32876803-17173547-62958100","span":{"begin":413,"end":417},"obj":"17173547"}],"attributes":[{"subj":"32876803-16260386-62958099","pred":"source","obj":"2_test"},{"subj":"32876803-17173547-62958100","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#a393ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#9cec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93b6"},{"id":"LitCovid-PD-CLO","color":"#93d0ec"},{"id":"LitCovid-PubTator","color":"#eaec93"},{"id":"LitCovid-PD-GO-BP","color":"#d393ec"},{"id":"LitCovid-sentences","color":"#93ecb9"},{"id":"2_test","color":"#ec9f93"}]}]}}