PMC:7463108 / 48992-49411 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T489","span":{"begin":28,"end":37},"obj":"Body_part"},{"id":"T490","span":{"begin":102,"end":105},"obj":"Body_part"},{"id":"T491","span":{"begin":113,"end":116},"obj":"Body_part"},{"id":"T492","span":{"begin":317,"end":326},"obj":"Body_part"}],"attributes":[{"id":"A489","pred":"fma_id","subj":"T489","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A490","pred":"fma_id","subj":"T490","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A491","pred":"fma_id","subj":"T491","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A492","pred":"fma_id","subj":"T492","obj":"http://purl.org/sig/ont/fma/fma68923"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T98","span":{"begin":113,"end":116},"obj":"Body_part"}],"attributes":[{"id":"A98","pred":"uberon_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T133","span":{"begin":362,"end":374},"obj":"Disease"}],"attributes":[{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T586","span":{"begin":28,"end":37},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T587","span":{"begin":113,"end":116},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T588","span":{"begin":113,"end":116},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T589","span":{"begin":113,"end":116},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T590","span":{"begin":317,"end":326},"obj":"http://purl.obolibrary.org/obo/CL_0000129"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1791","span":{"begin":102,"end":105},"obj":"Species"},{"id":"1792","span":{"begin":362,"end":374},"obj":"Disease"},{"id":"1793","span":{"begin":379,"end":391},"obj":"Disease"}],"attributes":[{"id":"A1791","pred":"tao:has_database_id","subj":"1791","obj":"Tax:12721"},{"id":"A1792","pred":"tao:has_database_id","subj":"1792","obj":"MESH:D007249"},{"id":"A1793","pred":"tao:has_database_id","subj":"1793","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T84","span":{"begin":362,"end":374},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T714","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"T715","span":{"begin":206,"end":406},"obj":"Sentence"},{"id":"T716","span":{"begin":407,"end":419},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}

{"project":"2_test","denotations":[{"id":"32876803-16260386-62958099","span":{"begin":407,"end":411},"obj":"16260386"},{"id":"32876803-17173547-62958100","span":{"begin":413,"end":417},"obj":"17173547"}],"text":"While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV. Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al. 2005, 2007)."}