PMC:7463108 / 43487-47302 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"The direct contributions of astrocytes to opioid and HIV interactions have been discussed previously (Dutta and Roy 2012; Hauser et al. 2012; Reddy et al. 2012; Hauser and Knapp 2014). Subsets of astroglia can express MOR, DOR and KOR (Stiene-Martin and Hauser 1991; Eriksson et al. 1992; Ruzicka et al. 1995; Gurwell et al. 1996; Hauser et al. 1996; Peterson et al. 1998; Stiene-Martin et al. 1998, 2001), as well as endogenous opioid peptides (Vilijn et al. 1988; Shinoda et al. 1989; Spruce et al. 1990; Hauser et al. 1990; Low et al. 1992). It appears that the ‘early’ events triggering the release of proinflammatory cytokines (i.e., TNF-α and IL-1β) from astroglia can be mediated by HIV Tat exposure alone (El-Hage et al. 2005, 2006a, b, 2008a). Opioids enhance HIV-1-induced inflammation later during the inflammatory cascade by exacerbating the sustained release of CCL5 from astrocytes, which subsequently triggers the release of CCL2 thereby enhancing the recruitment and activation of macrophages/microglia (El-Hage et al. 2008a) (Fig. 1). This is caused by the morphine-dependent exacerbation of Tat-induced increases in intracellular calcium concentration ([Ca2+]i) in astroglia (El-Hage et al. 2005), which accelerates the trafficking of NF-κB p65 (RelA) subunits to the nucleus and sustained CCL2, CCL5, and IL-6 transcription in astrocytes (El-Hage et al. 2008b).\nFig. 1 Opioids exacerbate HIV-1-induced CNS inflammation, in part, by augmenting CCL5-dependent increases in CCL2—key sites of opioid-HIV convergent interactions in glial inflammatory signaling cascades. Subpopulations of striatal glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in wildtype mice normally express CCR2 immunoreactivity (a-b; arrows), CCL2 (c; arrow), or μ-opioid receptor (MOR) (d; arrows) immunoreactivity (scale bars a-b = 25 μm; c-d = 15 μm). CCR2 deletion (−/−) significantly reduces HIV-1 Tat ± morphine-induced increases in GFAP+ astroglia (e) and F4/80+ macrophages/microglia (f) compared to wild type (+/+) mice at sites near (300 ± 100 μm) the site of Tat injection (*p \u003c 0.05 vs. wild type mice) (see, El-Hage et al. 2006a). In wild-type mice, Tat ± morphine administration markedly increases the proportion of CCL2 immunoreactive astrocytes (g) or macrophages/microglia (h) [*p \u003c 0.05 vs. other groups in wild-type or CCL5(−/−) mice; bp \u003c 0.05 vs. vehicle- or Tat plus morphine-treated wild-type mice; #p \u003c 0.05 vs. equivalent treatment in wild-type mice], while in CCL5 null mice, significant increases in CCL2 immunoreactivity were only seen in macrophages/microglia co-exposed to Tat and morphine (§p \u003c 0.05 vs. vehicle injected CCL5 knockout mice) (see, El-Hage et al. 2008a). CCL5 expression in striatal GFAP-immunoreactive astrocytes (arrows) increases following Tat injections (i, j) compared to wild-type control mice (not shown) (El-Hage et al. 2008a). Opioids exacerbate HIV-1-induced CNS inflammation, in part, by increasing CCL5 and augmenting CCR5-dependent increases in CCL2 production by astrocytes resulting in the activation and recruitment of microglia/macrophages and spiraling inflammation (k). Additional factors likely mediate the proinflammatory cascade, but these are less well substantiated (?). Moreover, autocrine and reciprocal paracrine (astroglial ↔ macrophage/microglial) intercellular, feedback amplification mechanisms from macrophages/microglia are likely to be operative (dashed red arrow) (also see, Kang and Hebert 2011) and occur elsewhere within the cascade (not shown); effects of HIV-1 Tat/HIV, red arrows; sites of opioid convergence, blue arrows; pro-BDNF:mature BDNF (mBDNF) ratio (Kim et al. 2018). (a-f) Modified and reprinted with permission from El-Hage et al. (2006a). (g-k) Modified and reprinted with permission from El-Hage et al. (2008a)","divisions":[{"label":"label","span":{"begin":1381,"end":1387}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T435","span":{"begin":28,"end":38},"obj":"Body_part"},{"id":"T436","span":{"begin":53,"end":56},"obj":"Body_part"},{"id":"T437","span":{"begin":622,"end":631},"obj":"Body_part"},{"id":"T438","span":{"begin":649,"end":653},"obj":"Body_part"},{"id":"T439","span":{"begin":690,"end":693},"obj":"Body_part"},{"id":"T440","span":{"begin":769,"end":772},"obj":"Body_part"},{"id":"T441","span":{"begin":885,"end":895},"obj":"Body_part"},{"id":"T442","span":{"begin":997,"end":1008},"obj":"Body_part"},{"id":"T443","span":{"begin":1009,"end":1018},"obj":"Body_part"},{"id":"T444","span":{"begin":1346,"end":1356},"obj":"Body_part"},{"id":"T445","span":{"begin":1407,"end":1410},"obj":"Body_part"},{"id":"T446","span":{"begin":1421,"end":1424},"obj":"Body_part"},{"id":"T447","span":{"begin":1515,"end":1518},"obj":"Body_part"},{"id":"T448","span":{"begin":1612,"end":1643},"obj":"Body_part"},{"id":"T449","span":{"begin":1645,"end":1649},"obj":"Body_part"},{"id":"T451","span":{"begin":1666,"end":1676},"obj":"Body_part"},{"id":"T452","span":{"begin":1902,"end":1905},"obj":"Body_part"},{"id":"T453","span":{"begin":1944,"end":1948},"obj":"Body_part"},{"id":"T455","span":{"begin":1975,"end":1986},"obj":"Body_part"},{"id":"T456","span":{"begin":1987,"end":1996},"obj":"Body_part"},{"id":"T457","span":{"begin":2255,"end":2265},"obj":"Body_part"},{"id":"T458","span":{"begin":2273,"end":2284},"obj":"Body_part"},{"id":"T459","span":{"begin":2285,"end":2294},"obj":"Body_part"},{"id":"T460","span":{"begin":2572,"end":2583},"obj":"Body_part"},{"id":"T461","span":{"begin":2584,"end":2593},"obj":"Body_part"},{"id":"T462","span":{"begin":2734,"end":2738},"obj":"Body_part"},{"id":"T464","span":{"begin":2754,"end":2764},"obj":"Body_part"},{"id":"T465","span":{"begin":2906,"end":2909},"obj":"Body_part"},{"id":"T466","span":{"begin":2920,"end":2923},"obj":"Body_part"},{"id":"T467","span":{"begin":3028,"end":3038},"obj":"Body_part"},{"id":"T468","span":{"begin":3086,"end":3095},"obj":"Body_part"},{"id":"T469","span":{"begin":3096,"end":3107},"obj":"Body_part"},{"id":"T470","span":{"begin":3305,"end":3315},"obj":"Body_part"},{"id":"T471","span":{"begin":3382,"end":3393},"obj":"Body_part"},{"id":"T472","span":{"begin":3394,"end":3403},"obj":"Body_part"},{"id":"T473","span":{"begin":3546,"end":3549},"obj":"Body_part"},{"id":"T474","span":{"begin":3556,"end":3559},"obj":"Body_part"}],"attributes":[{"id":"A435","pred":"fma_id","subj":"T435","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A437","pred":"fma_id","subj":"T437","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A438","pred":"fma_id","subj":"T438","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A439","pred":"fma_id","subj":"T439","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A440","pred":"fma_id","subj":"T440","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A441","pred":"fma_id","subj":"T441","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A442","pred":"fma_id","subj":"T442","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A443","pred":"fma_id","subj":"T443","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A444","pred":"fma_id","subj":"T444","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A445","pred":"fma_id","subj":"T445","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A446","pred":"fma_id","subj":"T446","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A447","pred":"fma_id","subj":"T447","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A448","pred":"fma_id","subj":"T448","obj":"http://purl.org/sig/ont/fma/fma63860"},{"id":"A449","pred":"fma_id","subj":"T449","obj":"http://purl.org/sig/ont/fma/fma67326"},{"id":"A450","pred":"fma_id","subj":"T449","obj":"http://purl.org/sig/ont/fma/fma63860"},{"id":"A451","pred":"fma_id","subj":"T451","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A452","pred":"fma_id","subj":"T452","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A453","pred":"fma_id","subj":"T453","obj":"http://purl.org/sig/ont/fma/fma67326"},{"id":"A454","pred":"fma_id","subj":"T453","obj":"http://purl.org/sig/ont/fma/fma63860"},{"id":"A455","pred":"fma_id","subj":"T455","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A456","pred":"fma_id","subj":"T456","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A457","pred":"fma_id","subj":"T457","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A458","pred":"fma_id","subj":"T458","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A459","pred":"fma_id","subj":"T459","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A460","pred":"fma_id","subj":"T460","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A461","pred":"fma_id","subj":"T461","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A462","pred":"fma_id","subj":"T462","obj":"http://purl.org/sig/ont/fma/fma67326"},{"id":"A463","pred":"fma_id","subj":"T462","obj":"http://purl.org/sig/ont/fma/fma63860"},{"id":"A464","pred":"fma_id","subj":"T464","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A465","pred":"fma_id","subj":"T465","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A466","pred":"fma_id","subj":"T466","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A467","pred":"fma_id","subj":"T467","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A468","pred":"fma_id","subj":"T468","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A469","pred":"fma_id","subj":"T469","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A470","pred":"fma_id","subj":"T470","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A471","pred":"fma_id","subj":"T471","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A472","pred":"fma_id","subj":"T472","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A473","pred":"fma_id","subj":"T473","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A474","pred":"fma_id","subj":"T474","obj":"http://purl.org/sig/ont/fma/fma278683"},{"subj":"T435","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T436","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T438","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T441","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T442","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T443","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T445","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T447","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T448","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T452","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T453","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T455","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T456","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T457","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T458","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T459","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T460","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T461","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T462","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T464","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T465","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T466","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T467","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T468","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T469","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T470","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T471","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T472","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T473","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T474","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T95","span":{"begin":1421,"end":1424},"obj":"Body_part"},{"id":"T96","span":{"begin":1822,"end":1827},"obj":"Body_part"},{"id":"T97","span":{"begin":2920,"end":2923},"obj":"Body_part"}],"attributes":[{"id":"A95","pred":"uberon_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A96","pred":"uberon_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A97","pred":"uberon_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T122","span":{"begin":783,"end":795},"obj":"Disease"},{"id":"T123","span":{"begin":1425,"end":1437},"obj":"Disease"},{"id":"T124","span":{"begin":2924,"end":2936},"obj":"Disease"},{"id":"T125","span":{"begin":3122,"end":3134},"obj":"Disease"}],"attributes":[{"id":"A122","pred":"mondo_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A123","pred":"mondo_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A124","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A125","pred":"mondo_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T538","span":{"begin":28,"end":38},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T539","span":{"begin":436,"end":444},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T540","span":{"begin":742,"end":743},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T541","span":{"begin":885,"end":895},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T542","span":{"begin":983,"end":993},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T543","span":{"begin":1009,"end":1018},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T544","span":{"begin":1257,"end":1258},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T545","span":{"begin":1346,"end":1356},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T546","span":{"begin":1421,"end":1424},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T547","span":{"begin":1421,"end":1424},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T548","span":{"begin":1421,"end":1424},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T549","span":{"begin":1565,"end":1574},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T550","span":{"begin":1666,"end":1676},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T551","span":{"begin":1734,"end":1735},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T552","span":{"begin":1736,"end":1737},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T553","span":{"begin":1833,"end":1834},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T554","span":{"begin":1835,"end":1836},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T555","span":{"begin":1968,"end":1973},"obj":"http://purl.obolibrary.org/obo/CLO_0002980"},{"id":"T556","span":{"begin":1987,"end":1996},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T557","span":{"begin":2255,"end":2265},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T558","span":{"begin":2285,"end":2294},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T559","span":{"begin":2295,"end":2302},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T560","span":{"begin":2295,"end":2302},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T561","span":{"begin":2295,"end":2302},"obj":"http://purl.obolibrary.org/obo/UBERON_0000007"},{"id":"T562","span":{"begin":2584,"end":2593},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T563","span":{"begin":2754,"end":2764},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T564","span":{"begin":2920,"end":2923},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T565","span":{"begin":2920,"end":2923},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T566","span":{"begin":2920,"end":2923},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T567","span":{"begin":3028,"end":3038},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T568","span":{"begin":3056,"end":3066},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T569","span":{"begin":3086,"end":3095},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T570","span":{"begin":3394,"end":3403},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T571","span":{"begin":3662,"end":3666},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T572","span":{"begin":3670,"end":3671},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T538","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T539","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T540","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T541","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T542","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T543","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T544","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T545","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T546","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T547","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T548","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T549","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T550","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T551","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T552","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T553","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T554","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T555","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T556","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T557","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T558","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T559","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T560","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T561","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T562","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T563","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T564","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T565","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T566","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T567","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T568","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T569","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T570","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T571","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T572","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T448","span":{"begin":436,"end":444},"obj":"Chemical"},{"id":"T449","span":{"begin":649,"end":651},"obj":"Chemical"},{"id":"T451","span":{"begin":1074,"end":1082},"obj":"Chemical"},{"id":"T453","span":{"begin":1148,"end":1155},"obj":"Chemical"},{"id":"T455","span":{"begin":1253,"end":1255},"obj":"Chemical"},{"id":"T458","span":{"begin":1286,"end":1293},"obj":"Chemical"},{"id":"T459","span":{"begin":1324,"end":1326},"obj":"Chemical"},{"id":"T461","span":{"begin":1636,"end":1643},"obj":"Chemical"},{"id":"T462","span":{"begin":1914,"end":1922},"obj":"Chemical"},{"id":"T464","span":{"begin":2174,"end":2182},"obj":"Chemical"},{"id":"T466","span":{"begin":2394,"end":2402},"obj":"Chemical"},{"id":"T468","span":{"begin":2616,"end":2624},"obj":"Chemical"}],"attributes":[{"id":"A448","pred":"chebi_id","subj":"T448","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A449","pred":"chebi_id","subj":"T449","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A450","pred":"chebi_id","subj":"T449","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A451","pred":"chebi_id","subj":"T451","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A452","pred":"chebi_id","subj":"T451","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A453","pred":"chebi_id","subj":"T453","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A454","pred":"chebi_id","subj":"T453","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A455","pred":"chebi_id","subj":"T455","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A456","pred":"chebi_id","subj":"T455","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A457","pred":"chebi_id","subj":"T455","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A458","pred":"chebi_id","subj":"T458","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A459","pred":"chebi_id","subj":"T459","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A460","pred":"chebi_id","subj":"T459","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A461","pred":"chebi_id","subj":"T461","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A462","pred":"chebi_id","subj":"T462","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A463","pred":"chebi_id","subj":"T462","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A464","pred":"chebi_id","subj":"T464","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A465","pred":"chebi_id","subj":"T464","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A466","pred":"chebi_id","subj":"T466","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A467","pred":"chebi_id","subj":"T466","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A468","pred":"chebi_id","subj":"T468","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A469","pred":"chebi_id","subj":"T468","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"subj":"T448","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T453","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T455","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T458","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T459","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T461","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T462","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T464","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T466","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T468","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1627","span":{"begin":1462,"end":1466},"obj":"Gene"},{"id":"1628","span":{"begin":1490,"end":1494},"obj":"Gene"},{"id":"1629","span":{"begin":1612,"end":1643},"obj":"Gene"},{"id":"1630","span":{"begin":1645,"end":1649},"obj":"Gene"},{"id":"1631","span":{"begin":1711,"end":1715},"obj":"Gene"},{"id":"1632","span":{"begin":1748,"end":1752},"obj":"Gene"},{"id":"1633","span":{"begin":1768,"end":1785},"obj":"Gene"},{"id":"1634","span":{"begin":1787,"end":1790},"obj":"Gene"},{"id":"1635","span":{"begin":1860,"end":1864},"obj":"Gene"},{"id":"1636","span":{"begin":1908,"end":1911},"obj":"Gene"},{"id":"1637","span":{"begin":1944,"end":1948},"obj":"Gene"},{"id":"1638","span":{"begin":2075,"end":2078},"obj":"Gene"},{"id":"1639","span":{"begin":2168,"end":2171},"obj":"Gene"},{"id":"1640","span":{"begin":2235,"end":2239},"obj":"Gene"},{"id":"1641","span":{"begin":2343,"end":2347},"obj":"Gene"},{"id":"1642","span":{"begin":2385,"end":2388},"obj":"Gene"},{"id":"1643","span":{"begin":2491,"end":2495},"obj":"Gene"},{"id":"1644","span":{"begin":2532,"end":2536},"obj":"Gene"},{"id":"1645","span":{"begin":2608,"end":2611},"obj":"Gene"},{"id":"1646","span":{"begin":2657,"end":2661},"obj":"Gene"},{"id":"1647","span":{"begin":2706,"end":2710},"obj":"Gene"},{"id":"1648","span":{"begin":2734,"end":2738},"obj":"Gene"},{"id":"1649","span":{"begin":2961,"end":2965},"obj":"Gene"},{"id":"1650","span":{"begin":2981,"end":2985},"obj":"Gene"},{"id":"1651","span":{"begin":3009,"end":3013},"obj":"Gene"},{"id":"1652","span":{"begin":3619,"end":3623},"obj":"Gene"},{"id":"1653","span":{"begin":3631,"end":3635},"obj":"Gene"},{"id":"1654","span":{"begin":3637,"end":3642},"obj":"Gene"},{"id":"1655","span":{"begin":2794,"end":2797},"obj":"Gene"},{"id":"1656","span":{"begin":3796,"end":3800},"obj":"Gene"},{"id":"1657","span":{"begin":3722,"end":3726},"obj":"Gene"},{"id":"1658","span":{"begin":2867,"end":2871},"obj":"Gene"},{"id":"1659","span":{"begin":2686,"end":2690},"obj":"Gene"},{"id":"1660","span":{"begin":2129,"end":2133},"obj":"Gene"},{"id":"1661","span":{"begin":1407,"end":1412},"obj":"Species"},{"id":"1662","span":{"begin":1689,"end":1693},"obj":"Species"},{"id":"1663","span":{"begin":1902,"end":1907},"obj":"Species"},{"id":"1664","span":{"begin":2029,"end":2033},"obj":"Species"},{"id":"1665","span":{"begin":2114,"end":2118},"obj":"Species"},{"id":"1666","span":{"begin":2162,"end":2166},"obj":"Species"},{"id":"1667","span":{"begin":2353,"end":2357},"obj":"Species"},{"id":"1668","span":{"begin":2421,"end":2425},"obj":"Species"},{"id":"1669","span":{"begin":2475,"end":2479},"obj":"Species"},{"id":"1670","span":{"begin":2501,"end":2505},"obj":"Species"},{"id":"1671","span":{"begin":2671,"end":2675},"obj":"Species"},{"id":"1672","span":{"begin":2846,"end":2850},"obj":"Species"},{"id":"1673","span":{"begin":2906,"end":2911},"obj":"Species"},{"id":"1674","span":{"begin":1515,"end":1518},"obj":"Species"},{"id":"1675","span":{"begin":1914,"end":1922},"obj":"Chemical"},{"id":"1676","span":{"begin":1421,"end":1437},"obj":"Disease"},{"id":"1677","span":{"begin":2920,"end":2936},"obj":"Disease"},{"id":"1678","span":{"begin":3122,"end":3134},"obj":"Disease"},{"id":"1679","span":{"begin":3546,"end":3559},"obj":"Disease"},{"id":"1705","span":{"begin":218,"end":221},"obj":"Gene"},{"id":"1706","span":{"begin":223,"end":226},"obj":"Gene"},{"id":"1707","span":{"begin":231,"end":234},"obj":"Gene"},{"id":"1708","span":{"begin":639,"end":644},"obj":"Gene"},{"id":"1709","span":{"begin":649,"end":654},"obj":"Gene"},{"id":"1710","span":{"begin":875,"end":879},"obj":"Gene"},{"id":"1711","span":{"begin":940,"end":944},"obj":"Gene"},{"id":"1712","span":{"begin":1109,"end":1112},"obj":"Gene"},{"id":"1713","span":{"begin":1253,"end":1262},"obj":"Gene"},{"id":"1714","span":{"begin":1264,"end":1268},"obj":"Gene"},{"id":"1715","span":{"begin":1308,"end":1312},"obj":"Gene"},{"id":"1716","span":{"begin":1314,"end":1318},"obj":"Gene"},{"id":"1717","span":{"begin":1324,"end":1328},"obj":"Gene"},{"id":"1718","span":{"begin":769,"end":774},"obj":"Species"},{"id":"1719","span":{"begin":53,"end":56},"obj":"Species"},{"id":"1720","span":{"begin":690,"end":693},"obj":"Species"},{"id":"1721","span":{"begin":694,"end":697},"obj":"Gene"},{"id":"1722","span":{"begin":1361,"end":1365},"obj":"Gene"},{"id":"1723","span":{"begin":1197,"end":1201},"obj":"Gene"},{"id":"1724","span":{"begin":1023,"end":1027},"obj":"Gene"},{"id":"1725","span":{"begin":717,"end":721},"obj":"Gene"},{"id":"1726","span":{"begin":1074,"end":1082},"obj":"Chemical"},{"id":"1727","span":{"begin":1148,"end":1155},"obj":"Chemical"},{"id":"1728","span":{"begin":1172,"end":1176},"obj":"Chemical"},{"id":"1729","span":{"begin":783,"end":795},"obj":"Disease"}],"attributes":[{"id":"A1627","pred":"tao:has_database_id","subj":"1627","obj":"Gene:6352"},{"id":"A1628","pred":"tao:has_database_id","subj":"1628","obj":"Gene:6347"},{"id":"A1629","pred":"tao:has_database_id","subj":"1629","obj":"Gene:14580"},{"id":"A1630","pred":"tao:has_database_id","subj":"1630","obj":"Gene:14580"},{"id":"A1631","pred":"tao:has_database_id","subj":"1631","obj":"Gene:12772"},{"id":"A1632","pred":"tao:has_database_id","subj":"1632","obj":"Gene:20296"},{"id":"A1633","pred":"tao:has_database_id","subj":"1633","obj":"Gene:18390"},{"id":"A1634","pred":"tao:has_database_id","subj":"1634","obj":"Gene:18390"},{"id":"A1635","pred":"tao:has_database_id","subj":"1635","obj":"Gene:729230"},{"id":"A1636","pred":"tao:has_database_id","subj":"1636","obj":"Gene:6898"},{"id":"A1637","pred":"tao:has_database_id","subj":"1637","obj":"Gene:2670"},{"id":"A1638","pred":"tao:has_database_id","subj":"1638","obj":"Gene:234724"},{"id":"A1639","pred":"tao:has_database_id","subj":"1639","obj":"Gene:234724"},{"id":"A1640","pred":"tao:has_database_id","subj":"1640","obj":"Gene:20296"},{"id":"A1641","pred":"tao:has_database_id","subj":"1641","obj":"Gene:20304"},{"id":"A1642","pred":"tao:has_database_id","subj":"1642","obj":"Gene:234724"},{"id":"A1643","pred":"tao:has_database_id","subj":"1643","obj":"Gene:20304"},{"id":"A1644","pred":"tao:has_database_id","subj":"1644","obj":"Gene:20296"},{"id":"A1645","pred":"tao:has_database_id","subj":"1645","obj":"Gene:234724"},{"id":"A1646","pred":"tao:has_database_id","subj":"1646","obj":"Gene:20304"},{"id":"A1647","pred":"tao:has_database_id","subj":"1647","obj":"Gene:20304"},{"id":"A1648","pred":"tao:has_database_id","subj":"1648","obj":"Gene:14580"},{"id":"A1649","pred":"tao:has_database_id","subj":"1649","obj":"Gene:6352"},{"id":"A1650","pred":"tao:has_database_id","subj":"1650","obj":"Gene:1234"},{"id":"A1651","pred":"tao:has_database_id","subj":"1651","obj":"Gene:6347"},{"id":"A1652","pred":"tao:has_database_id","subj":"1652","obj":"Gene:627"},{"id":"A1653","pred":"tao:has_database_id","subj":"1653","obj":"Gene:627"},{"id":"A1654","pred":"tao:has_database_id","subj":"1654","obj":"Gene:12064"},{"id":"A1655","pred":"tao:has_database_id","subj":"1655","obj":"Gene:234724"},{"id":"A1656","pred":"tao:has_database_id","subj":"1656","obj":"Gene:55510"},{"id":"A1657","pred":"tao:has_database_id","subj":"1657","obj":"Gene:55510"},{"id":"A1658","pred":"tao:has_database_id","subj":"1658","obj":"Gene:55510"},{"id":"A1659","pred":"tao:has_database_id","subj":"1659","obj":"Gene:55510"},{"id":"A1660","pred":"tao:has_database_id","subj":"1660","obj":"Gene:55510"},{"id":"A1661","pred":"tao:has_database_id","subj":"1661","obj":"Tax:11676"},{"id":"A1662","pred":"tao:has_database_id","subj":"1662","obj":"Tax:10090"},{"id":"A1663","pred":"tao:has_database_id","subj":"1663","obj":"Tax:11676"},{"id":"A1664","pred":"tao:has_database_id","subj":"1664","obj":"Tax:10090"},{"id":"A1665","pred":"tao:has_database_id","subj":"1665","obj":"Tax:10090"},{"id":"A1666","pred":"tao:has_database_id","subj":"1666","obj":"Tax:10090"},{"id":"A1667","pred":"tao:has_database_id","subj":"1667","obj":"Tax:10090"},{"id":"A1668","pred":"tao:has_database_id","subj":"1668","obj":"Tax:10090"},{"id":"A1669","pred":"tao:has_database_id","subj":"1669","obj":"Tax:10090"},{"id":"A1670","pred":"tao:has_database_id","subj":"1670","obj":"Tax:10090"},{"id":"A1671","pred":"tao:has_database_id","subj":"1671","obj":"Tax:10090"},{"id":"A1672","pred":"tao:has_database_id","subj":"1672","obj":"Tax:10090"},{"id":"A1673","pred":"tao:has_database_id","subj":"1673","obj":"Tax:11676"},{"id":"A1674","pred":"tao:has_database_id","subj":"1674","obj":"Tax:12721"},{"id":"A1675","pred":"tao:has_database_id","subj":"1675","obj":"MESH:D009020"},{"id":"A1676","pred":"tao:has_database_id","subj":"1676","obj":"MESH:D007249"},{"id":"A1677","pred":"tao:has_database_id","subj":"1677","obj":"MESH:D007249"},{"id":"A1678","pred":"tao:has_database_id","subj":"1678","obj":"MESH:D007249"},{"id":"A1679","pred":"tao:has_database_id","subj":"1679","obj":"MESH:D015658"},{"id":"A1705","pred":"tao:has_database_id","subj":"1705","obj":"Gene:4988"},{"id":"A1706","pred":"tao:has_database_id","subj":"1706","obj":"Gene:58476"},{"id":"A1707","pred":"tao:has_database_id","subj":"1707","obj":"Gene:4986"},{"id":"A1708","pred":"tao:has_database_id","subj":"1708","obj":"Gene:7124"},{"id":"A1709","pred":"tao:has_database_id","subj":"1709","obj":"Gene:3552"},{"id":"A1710","pred":"tao:has_database_id","subj":"1710","obj":"Gene:6352"},{"id":"A1711","pred":"tao:has_database_id","subj":"1711","obj":"Gene:6347"},{"id":"A1712","pred":"tao:has_database_id","subj":"1712","obj":"Gene:6898"},{"id":"A1713","pred":"tao:has_database_id","subj":"1713","obj":"Gene:5970"},{"id":"A1714","pred":"tao:has_database_id","subj":"1714","obj":"Gene:5970"},{"id":"A1715","pred":"tao:has_database_id","subj":"1715","obj":"Gene:6347"},{"id":"A1716","pred":"tao:has_database_id","subj":"1716","obj":"Gene:6352"},{"id":"A1717","pred":"tao:has_database_id","subj":"1717","obj":"Gene:3569"},{"id":"A1718","pred":"tao:has_database_id","subj":"1718","obj":"Tax:11676"},{"id":"A1719","pred":"tao:has_database_id","subj":"1719","obj":"Tax:12721"},{"id":"A1720","pred":"tao:has_database_id","subj":"1720","obj":"Tax:12721"},{"id":"A1721","pred":"tao:has_database_id","subj":"1721","obj":"Gene:6898"},{"id":"A1722","pred":"tao:has_database_id","subj":"1722","obj":"Gene:55510"},{"id":"A1723","pred":"tao:has_database_id","subj":"1723","obj":"Gene:55510"},{"id":"A1724","pred":"tao:has_database_id","subj":"1724","obj":"Gene:55510"},{"id":"A1725","pred":"tao:has_database_id","subj":"1725","obj":"Gene:55510"},{"id":"A1726","pred":"tao:has_database_id","subj":"1726","obj":"MESH:D009020"},{"id":"A1727","pred":"tao:has_database_id","subj":"1727","obj":"MESH:D002118"},{"id":"A1728","pred":"tao:has_database_id","subj":"1728","obj":"MESH:D000069285"},{"id":"A1729","pred":"tao:has_database_id","subj":"1729","obj":"MESH:D007249"},{"subj":"1627","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1628","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1629","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1630","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1631","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1632","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1633","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1634","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1635","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1636","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1637","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1638","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1639","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1640","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1641","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1642","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1643","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1644","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1645","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1646","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1647","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1648","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1649","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1650","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1651","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1652","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1653","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1654","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1655","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1656","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1657","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1658","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1659","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1660","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1661","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1662","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1663","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1664","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1665","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1666","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1667","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1668","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1669","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1670","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1671","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1672","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1673","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1674","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1675","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1676","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1677","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1678","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1679","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1705","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1706","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1707","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1708","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1709","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1710","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1711","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1712","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1713","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1714","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1715","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1716","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1717","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1718","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1719","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1720","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1721","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1722","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1723","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1724","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1725","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1726","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1727","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1728","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1729","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T73","span":{"begin":783,"end":795},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T74","span":{"begin":1329,"end":1342},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T75","span":{"begin":1425,"end":1437},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T76","span":{"begin":1565,"end":1583},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T77","span":{"begin":1565,"end":1574},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T78","span":{"begin":2924,"end":2936},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T79","span":{"begin":3009,"end":3024},"obj":"http://purl.obolibrary.org/obo/GO_0071605"},{"id":"T80","span":{"begin":3122,"end":3134},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T73","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T664","span":{"begin":0,"end":135},"obj":"Sentence"},{"id":"T665","span":{"begin":136,"end":154},"obj":"Sentence"},{"id":"T666","span":{"begin":155,"end":184},"obj":"Sentence"},{"id":"T667","span":{"begin":185,"end":282},"obj":"Sentence"},{"id":"T668","span":{"begin":283,"end":303},"obj":"Sentence"},{"id":"T669","span":{"begin":304,"end":324},"obj":"Sentence"},{"id":"T670","span":{"begin":325,"end":344},"obj":"Sentence"},{"id":"T671","span":{"begin":345,"end":366},"obj":"Sentence"},{"id":"T672","span":{"begin":367,"end":393},"obj":"Sentence"},{"id":"T673","span":{"begin":394,"end":459},"obj":"Sentence"},{"id":"T674","span":{"begin":460,"end":480},"obj":"Sentence"},{"id":"T675","span":{"begin":481,"end":500},"obj":"Sentence"},{"id":"T676","span":{"begin":501,"end":520},"obj":"Sentence"},{"id":"T677","span":{"begin":521,"end":537},"obj":"Sentence"},{"id":"T678","span":{"begin":538,"end":544},"obj":"Sentence"},{"id":"T679","span":{"begin":545,"end":728},"obj":"Sentence"},{"id":"T680","span":{"begin":729,"end":752},"obj":"Sentence"},{"id":"T681","span":{"begin":753,"end":1034},"obj":"Sentence"},{"id":"T682","span":{"begin":1035,"end":1051},"obj":"Sentence"},{"id":"T683","span":{"begin":1052,"end":1208},"obj":"Sentence"},{"id":"T684","span":{"begin":1209,"end":1372},"obj":"Sentence"},{"id":"T685","span":{"begin":1373,"end":1380},"obj":"Sentence"},{"id":"T686","span":{"begin":1381,"end":1584},"obj":"Sentence"},{"id":"T687","span":{"begin":1585,"end":1859},"obj":"Sentence"},{"id":"T688","span":{"begin":1860,"end":2140},"obj":"Sentence"},{"id":"T689","span":{"begin":2141,"end":2148},"obj":"Sentence"},{"id":"T690","span":{"begin":2149,"end":2697},"obj":"Sentence"},{"id":"T691","span":{"begin":2698,"end":2705},"obj":"Sentence"},{"id":"T692","span":{"begin":2706,"end":2878},"obj":"Sentence"},{"id":"T693","span":{"begin":2879,"end":2886},"obj":"Sentence"},{"id":"T694","span":{"begin":2887,"end":3139},"obj":"Sentence"},{"id":"T695","span":{"begin":3140,"end":3245},"obj":"Sentence"},{"id":"T696","span":{"begin":3246,"end":3661},"obj":"Sentence"},{"id":"T697","span":{"begin":3662,"end":3815},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T664","pred":"source","obj":"LitCovid-sentences"},{"subj":"T665","pred":"source","obj":"LitCovid-sentences"},{"subj":"T666","pred":"source","obj":"LitCovid-sentences"},{"subj":"T667","pred":"source","obj":"LitCovid-sentences"},{"subj":"T668","pred":"source","obj":"LitCovid-sentences"},{"subj":"T669","pred":"source","obj":"LitCovid-sentences"},{"subj":"T670","pred":"source","obj":"LitCovid-sentences"},{"subj":"T671","pred":"source","obj":"LitCovid-sentences"},{"subj":"T672","pred":"source","obj":"LitCovid-sentences"},{"subj":"T673","pred":"source","obj":"LitCovid-sentences"},{"subj":"T674","pred":"source","obj":"LitCovid-sentences"},{"subj":"T675","pred":"source","obj":"LitCovid-sentences"},{"subj":"T676","pred":"source","obj":"LitCovid-sentences"},{"subj":"T677","pred":"source","obj":"LitCovid-sentences"},{"subj":"T678","pred":"source","obj":"LitCovid-sentences"},{"subj":"T679","pred":"source","obj":"LitCovid-sentences"},{"subj":"T680","pred":"source","obj":"LitCovid-sentences"},{"subj":"T681","pred":"source","obj":"LitCovid-sentences"},{"subj":"T682","pred":"source","obj":"LitCovid-sentences"},{"subj":"T683","pred":"source","obj":"LitCovid-sentences"},{"subj":"T684","pred":"source","obj":"LitCovid-sentences"},{"subj":"T685","pred":"source","obj":"LitCovid-sentences"},{"subj":"T686","pred":"source","obj":"LitCovid-sentences"},{"subj":"T687","pred":"source","obj":"LitCovid-sentences"},{"subj":"T688","pred":"source","obj":"LitCovid-sentences"},{"subj":"T689","pred":"source","obj":"LitCovid-sentences"},{"subj":"T690","pred":"source","obj":"LitCovid-sentences"},{"subj":"T691","pred":"source","obj":"LitCovid-sentences"},{"subj":"T692","pred":"source","obj":"LitCovid-sentences"},{"subj":"T693","pred":"source","obj":"LitCovid-sentences"},{"subj":"T694","pred":"source","obj":"LitCovid-sentences"},{"subj":"T695","pred":"source","obj":"LitCovid-sentences"},{"subj":"T696","pred":"source","obj":"LitCovid-sentences"},{"subj":"T697","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32876803-22591371-62958083","span":{"begin":116,"end":120},"obj":"22591371"},{"id":"32876803-22591368-62958084","span":{"begin":136,"end":140},"obj":"22591368"},{"id":"32876803-22666564-62958085","span":{"begin":155,"end":159},"obj":"22666564"},{"id":"32876803-25175867-62958086","span":{"begin":178,"end":182},"obj":"25175867"},{"id":"32876803-1665190-62958087","span":{"begin":261,"end":265},"obj":"1665190"},{"id":"32876803-1318509-62958088","span":{"begin":283,"end":287},"obj":"1318509"},{"id":"32876803-8930364-62958089","span":{"begin":325,"end":329},"obj":"8930364"},{"id":"32876803-9610674-62958090","span":{"begin":367,"end":371},"obj":"9610674"},{"id":"32876803-11571786-62958091","span":{"begin":400,"end":404},"obj":"11571786"},{"id":"32876803-3413111-62958092","span":{"begin":460,"end":464},"obj":"3413111"},{"id":"32876803-2569236-62958093","span":{"begin":481,"end":485},"obj":"2569236"},{"id":"32876803-2224534-62958094","span":{"begin":521,"end":525},"obj":"2224534"},{"id":"32876803-1396335-62958095","span":{"begin":538,"end":542},"obj":"1396335"},{"id":"32876803-21234816-62958096","span":{"begin":3477,"end":3481},"obj":"21234816"}],"attributes":[{"subj":"32876803-22591371-62958083","pred":"source","obj":"2_test"},{"subj":"32876803-22591368-62958084","pred":"source","obj":"2_test"},{"subj":"32876803-22666564-62958085","pred":"source","obj":"2_test"},{"subj":"32876803-25175867-62958086","pred":"source","obj":"2_test"},{"subj":"32876803-1665190-62958087","pred":"source","obj":"2_test"},{"subj":"32876803-1318509-62958088","pred":"source","obj":"2_test"},{"subj":"32876803-8930364-62958089","pred":"source","obj":"2_test"},{"subj":"32876803-9610674-62958090","pred":"source","obj":"2_test"},{"subj":"32876803-11571786-62958091","pred":"source","obj":"2_test"},{"subj":"32876803-3413111-62958092","pred":"source","obj":"2_test"},{"subj":"32876803-2569236-62958093","pred":"source","obj":"2_test"},{"subj":"32876803-2224534-62958094","pred":"source","obj":"2_test"},{"subj":"32876803-1396335-62958095","pred":"source","obj":"2_test"},{"subj":"32876803-21234816-62958096","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecdc93","default":true},{"id":"LitCovid-PD-UBERON","color":"#c293ec"},{"id":"LitCovid-PD-MONDO","color":"#93eca8"},{"id":"LitCovid-PD-CLO","color":"#ec9397"},{"id":"LitCovid-PD-CHEBI","color":"#93b1ec"},{"id":"LitCovid-PubTator","color":"#cbec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93e5"},{"id":"LitCovid-sentences","color":"#93ecd8"},{"id":"2_test","color":"#ecbe93"}]}]}}