PMC:7463108 / 32062-32435 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T280","span":{"begin":0,"end":3},"obj":"Body_part"},{"id":"T281","span":{"begin":126,"end":129},"obj":"Body_part"},{"id":"T282","span":{"begin":162,"end":171},"obj":"Body_part"},{"id":"T283","span":{"begin":235,"end":238},"obj":"Body_part"},{"id":"T284","span":{"begin":273,"end":278},"obj":"Body_part"},{"id":"T285","span":{"begin":294,"end":304},"obj":"Body_part"},{"id":"T286","span":{"begin":309,"end":318},"obj":"Body_part"},{"id":"T287","span":{"begin":329,"end":334},"obj":"Body_part"}],"attributes":[{"id":"A280","pred":"fma_id","subj":"T280","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A281","pred":"fma_id","subj":"T281","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A282","pred":"fma_id","subj":"T282","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A283","pred":"fma_id","subj":"T283","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A284","pred":"fma_id","subj":"T284","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine\nCCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine\n• MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al. 2013; Arnatt et al. 2016)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T81","span":{"begin":48,"end":50},"obj":"Disease"},{"id":"T82","span":{"begin":126,"end":139},"obj":"Disease"},{"id":"T83","span":{"begin":130,"end":139},"obj":"Disease"}],"attributes":[{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0016654"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005109"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine\nCCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine\n• MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al. 2013; Arnatt et al. 2016)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T360","span":{"begin":162,"end":171},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T361","span":{"begin":254,"end":257},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T362","span":{"begin":273,"end":278},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T363","span":{"begin":279,"end":284},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T364","span":{"begin":294,"end":304},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T365","span":{"begin":309,"end":318},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T366","span":{"begin":324,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T367","span":{"begin":324,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T368","span":{"begin":324,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T369","span":{"begin":329,"end":334},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine\nCCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine\n• MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al. 2013; Arnatt et al. 2016)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T258","span":{"begin":55,"end":63},"obj":"Chemical"},{"id":"T259","span":{"begin":82,"end":88},"obj":"Chemical"},{"id":"T260","span":{"begin":112,"end":118},"obj":"Chemical"},{"id":"T261","span":{"begin":178,"end":186},"obj":"Chemical"},{"id":"T263","span":{"begin":207,"end":213},"obj":"Chemical"}],"attributes":[{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A262","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"}],"text":"HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine\nCCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine\n• MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al. 2013; Arnatt et al. 2016)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1204","span":{"begin":16,"end":19},"obj":"Gene"},{"id":"1205","span":{"begin":20,"end":24},"obj":"Gene"},{"id":"1206","span":{"begin":94,"end":97},"obj":"Gene"},{"id":"1207","span":{"begin":98,"end":102},"obj":"Gene"},{"id":"1208","span":{"begin":189,"end":192},"obj":"Gene"},{"id":"1209","span":{"begin":193,"end":197},"obj":"Gene"},{"id":"1210","span":{"begin":239,"end":244},"obj":"Gene"},{"id":"1211","span":{"begin":249,"end":253},"obj":"Gene"},{"id":"1212","span":{"begin":254,"end":257},"obj":"Gene"},{"id":"1347","span":{"begin":69,"end":72},"obj":"Gene"},{"id":"1364","span":{"begin":279,"end":284},"obj":"Species"},{"id":"1409","span":{"begin":0,"end":3},"obj":"Species"},{"id":"1410","span":{"begin":235,"end":238},"obj":"Species"},{"id":"1440","span":{"begin":119,"end":139},"obj":"Disease"},{"id":"1458","span":{"begin":269,"end":272},"obj":"CellLine"},{"id":"1459","span":{"begin":320,"end":328},"obj":"CellLine"}],"attributes":[{"id":"A1204","pred":"tao:has_database_id","subj":"1204","obj":"Gene:4988"},{"id":"A1205","pred":"tao:has_database_id","subj":"1205","obj":"Gene:1234"},{"id":"A1206","pred":"tao:has_database_id","subj":"1206","obj":"Gene:4988"},{"id":"A1207","pred":"tao:has_database_id","subj":"1207","obj":"Gene:1234"},{"id":"A1208","pred":"tao:has_database_id","subj":"1208","obj":"Gene:4988"},{"id":"A1209","pred":"tao:has_database_id","subj":"1209","obj":"Gene:1234"},{"id":"A1210","pred":"tao:has_database_id","subj":"1210","obj":"Gene:2028"},{"id":"A1211","pred":"tao:has_database_id","subj":"1211","obj":"Gene:1234"},{"id":"A1212","pred":"tao:has_database_id","subj":"1212","obj":"Gene:920"},{"id":"A1347","pred":"tao:has_database_id","subj":"1347","obj":"Gene:4988"},{"id":"A1364","pred":"tao:has_database_id","subj":"1364","obj":"Tax:9606"},{"id":"A1409","pred":"tao:has_database_id","subj":"1409","obj":"Tax:12721"},{"id":"A1410","pred":"tao:has_database_id","subj":"1410","obj":"Tax:12721"},{"id":"A1440","pred":"tao:has_database_id","subj":"1440","obj":"MESH:D015658"},{"id":"A1458","pred":"tao:has_database_id","subj":"1458","obj":"CVCL:M624"},{"id":"A1459","pred":"tao:has_database_id","subj":"1459","obj":"CVCL:0063"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine\nCCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine\n• MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al. 2013; Arnatt et al. 2016)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T462","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T463","span":{"begin":64,"end":186},"obj":"Sentence"},{"id":"T464","span":{"begin":187,"end":347},"obj":"Sentence"},{"id":"T465","span":{"begin":348,"end":367},"obj":"Sentence"},{"id":"T466","span":{"begin":368,"end":373},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine\nCCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine\n• MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al. 2013; Arnatt et al. 2016)"}

{"project":"2_test","denotations":[{"id":"32876803-23682308-62958043","span":{"begin":348,"end":352},"obj":"23682308"},{"id":"32876803-27720326-62958044","span":{"begin":368,"end":372},"obj":"27720326"}],"text":"HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine\nCCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine\n• MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al. 2013; Arnatt et al. 2016)"}