PMC:7461420 / 79434-79903 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"HTS of a chemical library of 25000 molecules identified 170 (Figure 37) as a dual SARS‐CoV‐1 PLpro (IC50, 10.9 µM) and MERS‐CoV PLpro (IC50, 6.2 µM) inhibitor. 200 This compound acts via competitive inhibition against MERS‐CoV PLpro, yet via allosteric inhibition against SARS‐CoV‐1 PLpro. This compound also exhibited a preference for SARS‐CoV‐1 PLpro and MERS‐CoV PLpro versus two human homologs of the PLpro, ubiquitin C‐terminal hydrolase, (hUCH‐L1) and (hUCH‐L3).","tracks":[{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T371","span":{"begin":0,"end":3},"obj":"Disease"},{"id":"T372","span":{"begin":82,"end":86},"obj":"Disease"},{"id":"T373","span":{"begin":273,"end":277},"obj":"Disease"},{"id":"T374","span":{"begin":337,"end":341},"obj":"Disease"}],"attributes":[{"id":"A371","pred":"mondo_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/MONDO_0011549"},{"id":"A372","pred":"mondo_id","subj":"T372","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A373","pred":"mondo_id","subj":"T373","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A374","pred":"mondo_id","subj":"T374","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T372","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T374","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T941","span":{"begin":7,"end":8},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T942","span":{"begin":75,"end":76},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T943","span":{"begin":320,"end":321},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T944","span":{"begin":384,"end":389},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"attributes":[{"subj":"T941","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T942","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T943","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T944","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T85927","span":{"begin":35,"end":44},"obj":"Chemical"},{"id":"T90186","span":{"begin":149,"end":158},"obj":"Chemical"}],"attributes":[{"id":"A53594","pred":"chebi_id","subj":"T85927","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A39348","pred":"chebi_id","subj":"T90186","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T85927","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T90186","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T75","span":{"begin":413,"end":443},"obj":"http://purl.obolibrary.org/obo/GO_0004843"}],"attributes":[{"subj":"T75","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2452","span":{"begin":413,"end":443},"obj":"Gene"},{"id":"2453","span":{"begin":446,"end":453},"obj":"Gene"},{"id":"2454","span":{"begin":460,"end":467},"obj":"Gene"},{"id":"2455","span":{"begin":82,"end":90},"obj":"Species"},{"id":"2456","span":{"begin":119,"end":127},"obj":"Species"},{"id":"2457","span":{"begin":219,"end":227},"obj":"Species"},{"id":"2458","span":{"begin":273,"end":281},"obj":"Species"},{"id":"2459","span":{"begin":337,"end":345},"obj":"Species"},{"id":"2460","span":{"begin":358,"end":366},"obj":"Species"},{"id":"2461","span":{"begin":384,"end":389},"obj":"Species"}],"attributes":[{"id":"A2452","pred":"tao:has_database_id","subj":"2452","obj":"Gene:7345"},{"id":"A2453","pred":"tao:has_database_id","subj":"2453","obj":"Gene:7345"},{"id":"A2454","pred":"tao:has_database_id","subj":"2454","obj":"Gene:7347"},{"id":"A2455","pred":"tao:has_database_id","subj":"2455","obj":"Tax:694009"},{"id":"A2456","pred":"tao:has_database_id","subj":"2456","obj":"Tax:1335626"},{"id":"A2457","pred":"tao:has_database_id","subj":"2457","obj":"Tax:1335626"},{"id":"A2458","pred":"tao:has_database_id","subj":"2458","obj":"Tax:694009"},{"id":"A2459","pred":"tao:has_database_id","subj":"2459","obj":"Tax:694009"},{"id":"A2460","pred":"tao:has_database_id","subj":"2460","obj":"Tax:1335626"},{"id":"A2461","pred":"tao:has_database_id","subj":"2461","obj":"Tax:9606"},{"subj":"2452","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2453","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2454","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2455","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2456","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2457","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2458","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2459","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2460","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2461","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T686","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"T687","span":{"begin":160,"end":290},"obj":"Sentence"},{"id":"T688","span":{"begin":291,"end":469},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T686","pred":"source","obj":"LitCovid-sentences"},{"subj":"T687","pred":"source","obj":"LitCovid-sentences"},{"subj":"T688","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-MONDO","color":"#93acec","default":true},{"id":"LitCovid-PD-CLO","color":"#c6ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93e0"},{"id":"LitCovid-PD-GO-BP","color":"#93ecdd"},{"id":"LitCovid-PubTator","color":"#ecc393"},{"id":"LitCovid-sentences","color":"#a993ec"}]}]}}