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PMC:7461420 / 79434-79903 JSONTXT

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LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T371 0-3 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T372 82-86 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T373 273-277 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T374 337-341 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T941 7-8 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T942 75-76 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T943 320-321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T944 384-389 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85927 35-44 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T90186 149-158 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T75 413-443 http://purl.obolibrary.org/obo/GO_0004843 denotes ubiquitin C‐terminal hydrolase

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2452 413-443 Gene denotes ubiquitin C‐terminal hydrolase Gene:7345
2453 446-453 Gene denotes hUCH‐L1 Gene:7345
2454 460-467 Gene denotes hUCH‐L3 Gene:7347
2455 82-90 Species denotes SARS‐CoV Tax:694009
2456 119-127 Species denotes MERS‐CoV Tax:1335626
2457 219-227 Species denotes MERS‐CoV Tax:1335626
2458 273-281 Species denotes SARS‐CoV Tax:694009
2459 337-345 Species denotes SARS‐CoV Tax:694009
2460 358-366 Species denotes MERS‐CoV Tax:1335626
2461 384-389 Species denotes human Tax:9606

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T686 0-159 Sentence denotes HTS of a chemical library of 25000 molecules identified 170 (Figure 37) as a dual SARS‐CoV‐1 PLpro (IC50, 10.9 µM) and MERS‐CoV PLpro (IC50, 6.2 µM) inhibitor.
T687 160-290 Sentence denotes 200 This compound acts via competitive inhibition against MERS‐CoV PLpro, yet via allosteric inhibition against SARS‐CoV‐1 PLpro.
T688 291-469 Sentence denotes This compound also exhibited a preference for SARS‐CoV‐1 PLpro and MERS‐CoV PLpro versus two human homologs of the PLpro, ubiquitin C‐terminal hydrolase, (hUCH‐L1) and (hUCH‐L3).