PMC:7461420 / 74387-74710 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T271","span":{"begin":33,"end":42},"obj":"Body_part"}],"attributes":[{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma67245"}],"text":"Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro. It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM. 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T357","span":{"begin":157,"end":161},"obj":"Disease"},{"id":"T358","span":{"begin":241,"end":245},"obj":"Disease"},{"id":"T359","span":{"begin":306,"end":310},"obj":"Disease"}],"attributes":[{"id":"A357","pred":"mondo_id","subj":"T357","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A358","pred":"mondo_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A359","pred":"mondo_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro. It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM. 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T882","span":{"begin":33,"end":42},"obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"T883","span":{"begin":78,"end":80},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T884","span":{"begin":85,"end":86},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T885","span":{"begin":140,"end":148},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T886","span":{"begin":217,"end":222},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T887","span":{"begin":252,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro. It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM. 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T57933","span":{"begin":33,"end":42},"obj":"Chemical"},{"id":"T63607","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T67742","span":{"begin":54,"end":64},"obj":"Chemical"},{"id":"T60928","span":{"begin":97,"end":106},"obj":"Chemical"}],"attributes":[{"id":"A60999","pred":"chebi_id","subj":"T57933","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A2891","pred":"chebi_id","subj":"T57933","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A32873","pred":"chebi_id","subj":"T63607","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"},{"id":"A91535","pred":"chebi_id","subj":"T67742","obj":"http://purl.obolibrary.org/obo/CHEBI_145999"},{"id":"A22333","pred":"chebi_id","subj":"T60928","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro. It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM. 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2346","span":{"begin":317,"end":321},"obj":"Gene"},{"id":"2347","span":{"begin":110,"end":114},"obj":"Gene"},{"id":"2348","span":{"begin":168,"end":172},"obj":"Gene"},{"id":"2349","span":{"begin":157,"end":165},"obj":"Species"},{"id":"2350","span":{"begin":306,"end":316},"obj":"Species"},{"id":"2351","span":{"begin":241,"end":251},"obj":"Species"},{"id":"2352","span":{"begin":33,"end":42},"obj":"Chemical"},{"id":"2353","span":{"begin":54,"end":64},"obj":"Chemical"}],"attributes":[{"id":"A2346","pred":"tao:has_database_id","subj":"2346","obj":"Gene:8673700"},{"id":"A2347","pred":"tao:has_database_id","subj":"2347","obj":"Gene:8673700"},{"id":"A2348","pred":"tao:has_database_id","subj":"2348","obj":"Gene:8673700"},{"id":"A2349","pred":"tao:has_database_id","subj":"2349","obj":"Tax:694009"},{"id":"A2350","pred":"tao:has_database_id","subj":"2350","obj":"Tax:2697049"},{"id":"A2351","pred":"tao:has_database_id","subj":"2351","obj":"Tax:2697049"},{"id":"A2352","pred":"tao:has_database_id","subj":"2352","obj":"MESH:D012701"},{"id":"A2353","pred":"tao:has_database_id","subj":"2353","obj":"MESH:D002928"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro. It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM. 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T642","span":{"begin":0,"end":115},"obj":"Sentence"},{"id":"T643","span":{"begin":116,"end":200},"obj":"Sentence"},{"id":"T644","span":{"begin":201,"end":323},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro. It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM. 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro)."}