PMC:7461420 / 74387-74710
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T271 | 33-42 | Body_part | denotes | serotonin | http://purl.org/sig/ont/fma/fma67245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T357 | 157-161 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T358 | 241-245 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T359 | 306-310 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T882 | 33-42 | http://purl.obolibrary.org/obo/CHEBI_28790 | denotes | serotonin |
| T883 | 78-80 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T884 | 85-86 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T885 | 140-148 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T886 | 217-222 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
| T887 | 252-260 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T57933 | 33-42 | Chemical | denotes | serotonin | http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546 |
| T63607 | 43-53 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T67742 | 54-64 | Chemical | denotes | cinanserin | http://purl.obolibrary.org/obo/CHEBI_145999 |
| T60928 | 97-106 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2346 | 317-321 | Gene | denotes | Mpro | Gene:8673700 |
| 2347 | 110-114 | Gene | denotes | Mpro | Gene:8673700 |
| 2348 | 168-172 | Gene | denotes | Mpro | Gene:8673700 |
| 2349 | 157-165 | Species | denotes | SARS‐CoV | Tax:694009 |
| 2350 | 306-316 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 2351 | 241-251 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 2352 | 33-42 | Chemical | denotes | serotonin | MESH:D012701 |
| 2353 | 54-64 | Chemical | denotes | cinanserin | MESH:D002928 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T642 | 0-115 | Sentence | denotes | Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro. |
| T643 | 116-200 | Sentence | denotes | It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM. |
| T644 | 201-323 | Sentence | denotes | 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro). |