PMC:7461420 / 72439-73077
Annnotations
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T346 | 67-71 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T868 | 19-20 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T869 | 162-168 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T870 | 373-381 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T871 | 508-509 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T70109 | 31-41 | Chemical | denotes | terpenoids | http://purl.obolibrary.org/obo/CHEBI_26873 |
| T15757 | 118-128 | Chemical | denotes | ferruginol | http://purl.obolibrary.org/obo/CHEBI_78274 |
| T36758 | 207-214 | Chemical | denotes | quinone | http://purl.obolibrary.org/obo/CHEBI_36141 |
| T94996 | 223-236 | Chemical | denotes | triterpenoids | http://purl.obolibrary.org/obo/CHEBI_36615 |
| T73008 | 237-246 | Chemical | denotes | celastrol | http://purl.obolibrary.org/obo/CHEBI_63959 |
| T79894 | 299-307 | Chemical | denotes | methanol | http://purl.obolibrary.org/obo/CHEBI_17790 |
| T67952 | 478-485 | Chemical | denotes | quinone | http://purl.obolibrary.org/obo/CHEBI_36141 |
| T30069 | 494-499 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T88567 | 604-614 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2287 | 76-80 | Gene | denotes | Mpro | Gene:8673700 |
| 2288 | 320-340 | Species | denotes | Tripterygium regelii | Tax:123485 |
| 2289 | 421-424 | Species | denotes | SAR | Tax:2698737 |
| 2290 | 67-75 | Species | denotes | SARS‐CoV | Tax:694009 |
| 2291 | 31-41 | Chemical | denotes | terpenoids | MESH:D013729 |
| 2292 | 118-128 | Chemical | denotes | ferruginol | MESH:C431074 |
| 2293 | 207-222 | Chemical | denotes | quinone‐methide | MESH:C068040 |
| 2294 | 223-236 | Chemical | denotes | triterpenoids | MESH:D014315 |
| 2295 | 237-246 | Chemical | denotes | celastrol | MESH:C050414 |
| 2296 | 254-266 | Chemical | denotes | pritimererin | |
| 2297 | 278-287 | Chemical | denotes | tingenone | MESH:C009492 |
| 2298 | 299-307 | Chemical | denotes | methanol | MESH:D000432 |
| 2299 | 478-485 | Chemical | denotes | quinone | MESH:C004532 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T626 | 101-178 | Sentence | denotes | 187 Among them, ferruginol (139; IC50 49.6 µM) was the most active compound. |
| T627 | 179-420 | Sentence | denotes | Additionally, they isolated quinone‐methide triterpenoids celastrol (140), pritimererin (141), and tingenone (142) from methanol extracts of Tripterygium regelii which exhibited fair inhibition activity (IC50 2.6, 9.9, 5.5 µM, respectively). |
| T628 | 421-555 | Sentence | denotes | SAR studies indicated that for effective inhibition, the quinone‐methide group in ring A and the more lipophilic ring E were critical. |
| T629 | 556-638 | Sentence | denotes | All compounds were characterized as competitive inhibitors using kinetic analyses. |