PMC:7461420 / 63109-63457
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"Benzotriazole esters (88–91; Figure 26) were discovered as novel nonpeptidic irreversible inhibitors of SARS‐CoV‐1 Mpro. 168 Among them, 91 exhibited the best enzymatic inhibitory activity, but no antiviral activity in cell‐based assays. The covalent binding mode of 91 was confirmed by electrospray ionization mass spectrometry (ESI‐MS) analyses.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T264","span":{"begin":220,"end":224},"obj":"Body_part"}],"attributes":[{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T297","span":{"begin":104,"end":108},"obj":"Disease"}],"attributes":[{"id":"A297","pred":"mondo_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T792","span":{"begin":181,"end":189},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T793","span":{"begin":208,"end":224},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T794","span":{"begin":335,"end":337},"obj":"http://purl.obolibrary.org/obo/CLO_0007874"}],"attributes":[{"subj":"T792","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T793","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T794","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T41984","span":{"begin":14,"end":20},"obj":"Chemical"},{"id":"T15863","span":{"begin":90,"end":100},"obj":"Chemical"},{"id":"T76768","span":{"begin":198,"end":207},"obj":"Chemical"},{"id":"T59369","span":{"begin":335,"end":337},"obj":"Chemical"}],"attributes":[{"id":"A38273","pred":"chebi_id","subj":"T41984","obj":"http://purl.obolibrary.org/obo/CHEBI_35701"},{"id":"A13665","pred":"chebi_id","subj":"T15863","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A91282","pred":"chebi_id","subj":"T76768","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A31524","pred":"chebi_id","subj":"T59369","obj":"http://purl.obolibrary.org/obo/CHEBI_73613"},{"subj":"T41984","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15863","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T76768","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T59369","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1925","span":{"begin":115,"end":119},"obj":"Gene"},{"id":"1926","span":{"begin":104,"end":112},"obj":"Species"},{"id":"1927","span":{"begin":0,"end":20},"obj":"Chemical"}],"attributes":[{"id":"A1925","pred":"tao:has_database_id","subj":"1925","obj":"Gene:8673700"},{"id":"A1926","pred":"tao:has_database_id","subj":"1926","obj":"Tax:694009"},{"subj":"1925","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1926","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1927","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T548","span":{"begin":0,"end":120},"obj":"Sentence"},{"id":"T549","span":{"begin":121,"end":238},"obj":"Sentence"},{"id":"T550","span":{"begin":239,"end":348},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T548","pred":"source","obj":"LitCovid-sentences"},{"subj":"T549","pred":"source","obj":"LitCovid-sentences"},{"subj":"T550","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec939d","default":true},{"id":"LitCovid-PD-MONDO","color":"#93b7ec"},{"id":"LitCovid-PD-CLO","color":"#d1ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93eb"},{"id":"LitCovid-PubTator","color":"#93ecd3"},{"id":"LitCovid-sentences","color":"#ecb993"}]}]}}