PMC:7461420 / 44302-44749
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"In general, inhibitors possessing a Michael acceptor group as a warhead moiety could form an irreversible (covalent) bond with the catalytic cysteine residue in the following manner (Figure 14): First, the cysteine residue undergoes 1,4‐addition at the inhibitor's Michael acceptor group (warhead). Rapid protonation of the α‐carbanion from His‐H+ leads to the covalent bond formation between the warhead of the inhibitor and the cysteine residue.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T213","span":{"begin":141,"end":149},"obj":"Body_part"},{"id":"T214","span":{"begin":206,"end":214},"obj":"Body_part"},{"id":"T215","span":{"begin":430,"end":438},"obj":"Body_part"}],"attributes":[{"id":"A213","pred":"fma_id","subj":"T213","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A215","pred":"fma_id","subj":"T215","obj":"http://purl.org/sig/ont/fma/fma82751"},{"subj":"T213","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T544","span":{"begin":34,"end":35},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T545","span":{"begin":62,"end":63},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T544","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T545","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T456","span":{"begin":12,"end":22},"obj":"Chemical"},{"id":"T457","span":{"begin":44,"end":52},"obj":"Chemical"},{"id":"T458","span":{"begin":53,"end":58},"obj":"Chemical"},{"id":"T459","span":{"begin":141,"end":157},"obj":"Chemical"},{"id":"T460","span":{"begin":141,"end":149},"obj":"Chemical"},{"id":"T461","span":{"begin":206,"end":222},"obj":"Chemical"},{"id":"T462","span":{"begin":206,"end":214},"obj":"Chemical"},{"id":"T463","span":{"begin":273,"end":281},"obj":"Chemical"},{"id":"T464","span":{"begin":282,"end":287},"obj":"Chemical"},{"id":"T465","span":{"begin":412,"end":421},"obj":"Chemical"},{"id":"T466","span":{"begin":430,"end":446},"obj":"Chemical"},{"id":"T467","span":{"begin":430,"end":438},"obj":"Chemical"}],"attributes":[{"id":"A456","pred":"chebi_id","subj":"T456","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A457","pred":"chebi_id","subj":"T457","obj":"http://purl.obolibrary.org/obo/CHEBI_15339"},{"id":"A458","pred":"chebi_id","subj":"T458","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A459","pred":"chebi_id","subj":"T459","obj":"http://purl.obolibrary.org/obo/CHEBI_32460"},{"id":"A460","pred":"chebi_id","subj":"T460","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A461","pred":"chebi_id","subj":"T461","obj":"http://purl.obolibrary.org/obo/CHEBI_32460"},{"id":"A462","pred":"chebi_id","subj":"T462","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A463","pred":"chebi_id","subj":"T463","obj":"http://purl.obolibrary.org/obo/CHEBI_15339"},{"id":"A464","pred":"chebi_id","subj":"T464","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A465","pred":"chebi_id","subj":"T465","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A466","pred":"chebi_id","subj":"T466","obj":"http://purl.obolibrary.org/obo/CHEBI_32460"},{"id":"A467","pred":"chebi_id","subj":"T467","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"subj":"T456","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T457","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T458","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T459","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T460","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T461","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T462","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T463","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T464","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T465","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T466","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T467","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T57","span":{"begin":375,"end":384},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T57","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1343","span":{"begin":141,"end":149},"obj":"Chemical"},{"id":"1344","span":{"begin":206,"end":214},"obj":"Chemical"},{"id":"1345","span":{"begin":324,"end":335},"obj":"Chemical"},{"id":"1346","span":{"begin":341,"end":344},"obj":"Chemical"},{"id":"1347","span":{"begin":430,"end":438},"obj":"Chemical"}],"attributes":[{"id":"A1343","pred":"tao:has_database_id","subj":"1343","obj":"MESH:D003545"},{"id":"A1344","pred":"tao:has_database_id","subj":"1344","obj":"MESH:D003545"},{"id":"A1346","pred":"tao:has_database_id","subj":"1346","obj":"MESH:D006639"},{"id":"A1347","pred":"tao:has_database_id","subj":"1347","obj":"MESH:D003545"},{"subj":"1343","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1344","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1345","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1346","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1347","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T404","span":{"begin":195,"end":298},"obj":"Sentence"},{"id":"T405","span":{"begin":299,"end":447},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T404","pred":"source","obj":"LitCovid-sentences"},{"subj":"T405","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93c3ec","default":true},{"id":"LitCovid-PD-CLO","color":"#ddec93"},{"id":"LitCovid-PD-CHEBI","color":"#e193ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecc7"},{"id":"LitCovid-PubTator","color":"#ecad93"},{"id":"LitCovid-sentences","color":"#9393ec"}]}]}}