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PMC:7461420 / 37460-38595 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T201 550-558 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T202 873-883 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T204 121-130 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T205 790-794 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T206 907-911 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T207 978-982 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T208 1025-1029 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T209 1035-1068 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T437 107-108 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T438 135-136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T439 228-235 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T440 427-428 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T441 463-464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T442 569-570 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T443 609-616 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptide
T444 654-655 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T445 704-712 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T446 759-766 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T447 873-891 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residue
T448 873-891 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residue
T449 904-905 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T450 951-952 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T336 25-40 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T337 30-40 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T338 62-67 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T339 343-353 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T340 470-479 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T341 550-558 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T342 609-616 Chemical denotes Peptide http://purl.obolibrary.org/obo/CHEBI_16670
T343 617-627 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T344 665-670 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T345 694-699 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T346 704-712 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T347 759-766 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T348 873-891 Chemical denotes amino acid residue http://purl.obolibrary.org/obo/CHEBI_33708
T349 873-883 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T350 873-878 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T351 879-883 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T352 987-1002 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T353 992-1002 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T56 217-226 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1153 25-29 Gene denotes Mpro Gene:8673700
1160 801-805 Gene denotes Mpro Gene:8673700
1161 361-365 Gene denotes Mpro Gene:8673700
1162 357-360 Species denotes CoV Tax:11118
1163 790-798 Species denotes SARS‐CoV Tax:694009
1164 550-558 Chemical denotes cysteine MESH:D003545
1165 109-130 Disease denotes coronavirus infection MESH:D018352
1173 1004-1008 Gene denotes Mpro Gene:8673700
1174 987-991 Gene denotes Mpro Gene:8673700
1175 918-922 Gene denotes Mpro Gene:8673700
1176 907-915 Species denotes SARS‐CoV Tax:694009
1177 978-986 Species denotes SARS‐CoV Tax:694009
1178 1025-1033 Species denotes SARS‐CoV Tax:694009
1179 1035-1080 Species denotes severe acute respiratory syndrome coronavirus Tax:694009

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T347 0-40 Sentence denotes 3.1.2 Substrate‐derived Mpro inhibitors
T348 41-131 Sentence denotes To date, no approved drugs or vaccines are available for treating a coronavirus infection.
T349 132-317 Sentence denotes In a race to identify chemotherapeutic options, various approaches, such as chemical synthesis, testing of natural products, and virtual screening of compound libraries, have been used.
T350 318-414 Sentence denotes The systematic design of inhibitors of CoV Mpro was essentially based on the enzyme's substrate.
T351 415-608 Sentence denotes In general, a substrate can be transformed into a good inhibitor by modifying part of its sequence such that it binds to the catalytic cysteine in either a reversible or an irreversible manner.
T352 609-746 Sentence denotes Peptide inhibitors are designed by attaching a reactive group (also known as warhead group) to peptides that mimic the natural substrate.
T353 747-892 Sentence denotes The partial peptide substrate sequence for SARS‐CoV‐1 Mpro is mentioned in Figure 10, indicating the specific subsite of each amino acid residue.
T354 893-950 Sentence denotes Figure 10 A, SARS‐CoV‐1 Mpro partial substrate sequence.
T355 951-1003 Sentence denotes B, (Overlay) structures of SARS‐CoV Mpro inhibitors.
T356 1004-1135 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus [Color figure can be viewed at wileyonlinelibrary.com]