PMC:7461420 / 33942-34215 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T186","span":{"begin":170,"end":175},"obj":"Body_part"}],"attributes":[{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"ssay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48\nPhenot"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T401","span":{"begin":137,"end":138},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T402","span":{"begin":165,"end":169},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T403","span":{"begin":165,"end":169},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T404","span":{"begin":165,"end":169},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T405","span":{"begin":170,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T406","span":{"begin":264,"end":266},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"}],"text":"ssay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48\nPhenot"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T304","span":{"begin":66,"end":75},"obj":"Chemical"}],"attributes":[{"id":"A304","pred":"chebi_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"ssay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48\nPhenot"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T45","span":{"begin":91,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0004175"}],"text":"ssay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48\nPhenot"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1077","span":{"begin":39,"end":101},"obj":"Gene"},{"id":"1078","span":{"begin":224,"end":236},"obj":"Disease"},{"id":"1079","span":{"begin":165,"end":169},"obj":"CellLine"}],"attributes":[{"id":"A1078","pred":"tao:has_database_id","subj":"1078","obj":"MESH:D064420"},{"id":"A1079","pred":"tao:has_database_id","subj":"1079","obj":"CVCL:0063"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ssay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48\nPhenot"}

{"project":"LitCovid-sentences","denotations":[{"id":"T315","span":{"begin":134,"end":263},"obj":"Sentence"},{"id":"T316","span":{"begin":264,"end":266},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ssay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48\nPhenot"}