PMC:7461420 / 18850-19140 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T106","span":{"begin":236,"end":241},"obj":"Body_part"}],"attributes":[{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM. Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells. 51 Imatinib (6; Figure 4), an Abelson kinase i"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T103","span":{"begin":45,"end":49},"obj":"Disease"},{"id":"T104","span":{"begin":181,"end":185},"obj":"Disease"}],"attributes":[{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM. Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells. 51 Imatinib (6; Figure 4), an Abelson kinase i"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T210","span":{"begin":13,"end":15},"obj":"http://purl.obolibrary.org/obo/CLO_0006987"},{"id":"T211","span":{"begin":33,"end":34},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T212","span":{"begin":160,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T213","span":{"begin":236,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM. Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells. 51 Imatinib (6; Figure 4), an Abelson kinase i"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T144","span":{"begin":9,"end":12},"obj":"Chemical"},{"id":"T145","span":{"begin":68,"end":77},"obj":"Chemical"}],"attributes":[{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_73344"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM. Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells. 51 Imatinib (6; Figure 4), an Abelson kinase i"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T15","span":{"begin":214,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0046718"},{"id":"T16","span":{"begin":220,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0044409"}],"text":"reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM. Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells. 51 Imatinib (6; Figure 4), an Abelson kinase i"}

{"project":"LitCovid-PubTator","denotations":[{"id":"599","span":{"begin":9,"end":28},"obj":"Gene"},{"id":"600","span":{"begin":45,"end":53},"obj":"Species"},{"id":"602","span":{"begin":247,"end":255},"obj":"Chemical"},{"id":"603","span":{"begin":181,"end":203},"obj":"Disease"}],"attributes":[{"id":"A600","pred":"tao:has_database_id","subj":"600","obj":"Tax:694009"},{"id":"A602","pred":"tao:has_database_id","subj":"602","obj":"MESH:D000068877"},{"id":"A603","pred":"tao:has_database_id","subj":"603","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM. Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells. 51 Imatinib (6; Figure 4), an Abelson kinase i"}

{"project":"LitCovid-sentences","denotations":[{"id":"T189","span":{"begin":103,"end":242},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM. Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells. 51 Imatinib (6; Figure 4), an Abelson kinase i"}