PMC:7461420 / 17344-18013 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"Small molecule entry inhibitors, on the other hand, are reported to target the RBD. Compared to peptides, proteins, and biologics, small molecules have several advantages due to lower production costs, improved pharmacokinetics, stability, and dosage accuracy. Sarafianos et al. identified the oxazole‐carboxamide derivative SSAA09E2 (1; Figure 4) as an entry inhibitor against SARS‐CoV‐1 by screening a chemical library composed of 3000 compounds. 47 This inhibitor directly blocks ACE2 recognition by interfering with the RBD with an EC50 value of 3.1 µM and a 50% cytotoxic concentration (CC50) value of greater than 100 µM, not affecting ACE2 expression levels. 48","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T102","span":{"begin":46,"end":50},"obj":"Body_part"},{"id":"T103","span":{"begin":106,"end":114},"obj":"Body_part"}],"attributes":[{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A103","pred":"fma_id","subj":"T103","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":46,"end":50},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T100","span":{"begin":378,"end":382},"obj":"Disease"}],"attributes":[{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T200","span":{"begin":96,"end":104},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T201","span":{"begin":402,"end":403},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T202","span":{"begin":562,"end":563},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T203","span":{"begin":667,"end":669},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"}],"attributes":[{"subj":"T200","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T124","span":{"begin":6,"end":14},"obj":"Chemical"},{"id":"T125","span":{"begin":21,"end":31},"obj":"Chemical"},{"id":"T126","span":{"begin":96,"end":104},"obj":"Chemical"},{"id":"T127","span":{"begin":106,"end":114},"obj":"Chemical"},{"id":"T128","span":{"begin":137,"end":146},"obj":"Chemical"},{"id":"T129","span":{"begin":294,"end":301},"obj":"Chemical"},{"id":"T131","span":{"begin":302,"end":313},"obj":"Chemical"},{"id":"T133","span":{"begin":360,"end":369},"obj":"Chemical"},{"id":"T134","span":{"begin":458,"end":467},"obj":"Chemical"}],"attributes":[{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_35597"},{"id":"A130","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_35790"},{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_23004"},{"id":"A132","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_37622"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"576","span":{"begin":484,"end":488},"obj":"Gene"},{"id":"577","span":{"begin":643,"end":647},"obj":"Gene"},{"id":"578","span":{"begin":378,"end":386},"obj":"Species"},{"id":"579","span":{"begin":294,"end":313},"obj":"Chemical"}],"attributes":[{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"Gene:59272"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"Gene:59272"},{"id":"A578","pred":"tao:has_database_id","subj":"578","obj":"Tax:694009"},{"subj":"576","pred":"source","obj":"LitCovid-PubTator"},{"subj":"577","pred":"source","obj":"LitCovid-PubTator"},{"subj":"578","pred":"source","obj":"LitCovid-PubTator"},{"subj":"579","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T175","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T176","span":{"begin":84,"end":260},"obj":"Sentence"},{"id":"T177","span":{"begin":261,"end":448},"obj":"Sentence"},{"id":"T178","span":{"begin":449,"end":666},"obj":"Sentence"},{"id":"T179","span":{"begin":667,"end":669},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T175","pred":"source","obj":"LitCovid-sentences"},{"subj":"T176","pred":"source","obj":"LitCovid-sentences"},{"subj":"T177","pred":"source","obj":"LitCovid-sentences"},{"subj":"T178","pred":"source","obj":"LitCovid-sentences"},{"subj":"T179","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93eccd","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecb393"},{"id":"LitCovid-PD-MONDO","color":"#9993ec"},{"id":"LitCovid-PD-CLO","color":"#a7ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93c1"},{"id":"LitCovid-PubTator","color":"#93dbec"},{"id":"LitCovid-sentences","color":"#ece393"}]}]}}