PMC:7461420 / 17344-18013
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T102 | 46-50 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T103 | 106-114 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 46-50 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T100 | 378-382 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T200 | 96-104 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptides |
| T201 | 402-403 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T202 | 562-563 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T203 | 667-669 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T124 | 6-14 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T125 | 21-31 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T126 | 96-104 | Chemical | denotes | peptides | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T127 | 106-114 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T128 | 137-146 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T129 | 294-301 | Chemical | denotes | oxazole | http://purl.obolibrary.org/obo/CHEBI_35597|http://purl.obolibrary.org/obo/CHEBI_35790 |
| T131 | 302-313 | Chemical | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 |
| T133 | 360-369 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T134 | 458-467 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 576 | 484-488 | Gene | denotes | ACE2 | Gene:59272 |
| 577 | 643-647 | Gene | denotes | ACE2 | Gene:59272 |
| 578 | 378-386 | Species | denotes | SARS‐CoV | Tax:694009 |
| 579 | 294-313 | Chemical | denotes | oxazole‐carboxamide |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T175 | 0-83 | Sentence | denotes | Small molecule entry inhibitors, on the other hand, are reported to target the RBD. |
| T176 | 84-260 | Sentence | denotes | Compared to peptides, proteins, and biologics, small molecules have several advantages due to lower production costs, improved pharmacokinetics, stability, and dosage accuracy. |
| T177 | 261-448 | Sentence | denotes | Sarafianos et al. identified the oxazole‐carboxamide derivative SSAA09E2 (1; Figure 4) as an entry inhibitor against SARS‐CoV‐1 by screening a chemical library composed of 3000 compounds. |
| T178 | 449-666 | Sentence | denotes | 47 This inhibitor directly blocks ACE2 recognition by interfering with the RBD with an EC50 value of 3.1 µM and a 50% cytotoxic concentration (CC50) value of greater than 100 µM, not affecting ACE2 expression levels. |
| T179 | 667-669 | Sentence | denotes | 48 |