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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T16","span":{"begin":65,"end":70},"obj":"Body_part"},{"id":"T17","span":{"begin":138,"end":143},"obj":"Body_part"},{"id":"T18","span":{"begin":150,"end":156},"obj":"Body_part"},{"id":"T19","span":{"begin":274,"end":285},"obj":"Body_part"},{"id":"T20","span":{"begin":396,"end":402},"obj":"Body_part"},{"id":"T21","span":{"begin":1120,"end":1126},"obj":"Body_part"},{"id":"T22","span":{"begin":1168,"end":1174},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0002371"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"2 The mononuclear phagocyte system (MPS)\nThe MPS is a dispersed organ, present throughout the body, with distinctive properties in every organ [21]. Tissue resident macrophage populations in the adult derive from embryonic progenitors and differ markedly in phenotype from bone marrow-derived monocytes, which are recruited to tissues in response to increased demand, for instance infection and tissue damage [19]. Monocyte- derived macrophages are the main generators of inflammation in COVID-19 [2,17,18,20,[22], [23], [24]]. These mononuclear phagocytes express a broad repertoire of plasma membrane and intracellular receptors, serving as sensors of micro-organisms, dying cells and soluble products, to mediate recognition, signaling, migration and activation [19]. Monocytes and macrophages are professional phagocytes, utilizing Fc, complement, Toll-like and non-opsonic lectin-like and scavenger receptors for ingestion, but are also highly active biosynthetic and secretory cells, contributing to inflammation, innate and adaptive cellular and humoral immunity and antimicrobial defences [21]. While promoting tissue homeostasis and repair, they also induce tissue injury, the proverbial two-edged sword. They interact readily with other cells through contact and soluble mediators including cytokines, chemokines and enzymes that activate plasma coagulation and complement cascades [24]; in addition, they generate reactive oxygen, nitrogen and arachidonate metabolites implicated in host inflammation and resolution [25]. By analogy with lymphocytes, their activation status is characterized for convenience as M1-type (pro-inflammatory) and M2-type (anti-inflammatory, reparative) [7]. Unlike T and B lymphocytes, mononuclear phagocytes are antigen non-specific, and only display a transient form of memory [26], primed to adapt to secondary challenges such as phagocytosis and microbial stimuli by further activation of potent secretory and cytotoxic pathways [7]. The level of activation covers a spectrum of effector mechanisms, constrained by inhibitory cytokines such as IL-10, IL-1 receptor antagonist [27] and transforming growth factor beta TGF-β, and by anti-inflammatory glucocorticoids and prostaglandins."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T30","span":{"begin":37,"end":40},"obj":"Disease"},{"id":"T31","span":{"begin":46,"end":49},"obj":"Disease"},{"id":"T32","span":{"begin":382,"end":391},"obj":"Disease"},{"id":"T33","span":{"begin":473,"end":485},"obj":"Disease"},{"id":"T34","span":{"begin":489,"end":497},"obj":"Disease"},{"id":"T35","span":{"begin":1007,"end":1019},"obj":"Disease"},{"id":"T36","span":{"begin":1175,"end":1181},"obj":"Disease"},{"id":"T37","span":{"begin":1500,"end":1512},"obj":"Disease"}],"attributes":[{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0019249"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0019249"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"2 The mononuclear phagocyte system (MPS)\nThe MPS is a dispersed organ, present throughout the body, with distinctive properties in every organ [21]. Tissue resident macrophage populations in the adult derive from embryonic progenitors and differ markedly in phenotype from bone marrow-derived monocytes, which are recruited to tissues in response to increased demand, for instance infection and tissue damage [19]. Monocyte- derived macrophages are the main generators of inflammation in COVID-19 [2,17,18,20,[22], [23], [24]]. These mononuclear phagocytes express a broad repertoire of plasma membrane and intracellular receptors, serving as sensors of micro-organisms, dying cells and soluble products, to mediate recognition, signaling, migration and activation [19]. Monocytes and macrophages are professional phagocytes, utilizing Fc, complement, Toll-like and non-opsonic lectin-like and scavenger receptors for ingestion, but are also highly active biosynthetic and secretory cells, contributing to inflammation, innate and adaptive cellular and humoral immunity and antimicrobial defences [21]. While promoting tissue homeostasis and repair, they also induce tissue injury, the proverbial two-edged sword. They interact readily with other cells through contact and soluble mediators including cytokines, chemokines and enzymes that activate plasma coagulation and complement cascades [24]; in addition, they generate reactive oxygen, nitrogen and arachidonate metabolites implicated in host inflammation and resolution [25]. By analogy with lymphocytes, their activation status is characterized for convenience as M1-type (pro-inflammatory) and M2-type (anti-inflammatory, reparative) [7]. Unlike T and B lymphocytes, mononuclear phagocytes are antigen non-specific, and only display a transient form of memory [26], primed to adapt to secondary challenges such as phagocytosis and microbial stimuli by further activation of potent secretory and cytotoxic pathways [7]. The level of activation covers a spectrum of effector mechanisms, constrained by inhibitory cytokines such as IL-10, IL-1 receptor antagonist [27] and transforming growth factor beta TGF-β, and by anti-inflammatory glucocorticoids and prostaglandins."}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T20","span":{"begin":473,"end":485},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T21","span":{"begin":730,"end":739},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T22","span":{"begin":1007,"end":1019},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T23","span":{"begin":1120,"end":1138},"obj":"http://purl.obolibrary.org/obo/GO_0001894"},{"id":"T24","span":{"begin":1127,"end":1138},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T25","span":{"begin":1357,"end":1368},"obj":"http://purl.obolibrary.org/obo/GO_0050817"},{"id":"T26","span":{"begin":1373,"end":1392},"obj":"http://purl.obolibrary.org/obo/GO_0006956"},{"id":"T27","span":{"begin":1500,"end":1512},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T28","span":{"begin":1550,"end":1579},"obj":"http://purl.obolibrary.org/obo/GO_0046649"},{"id":"T29","span":{"begin":1813,"end":1819},"obj":"http://purl.obolibrary.org/obo/GO_0007613"},{"id":"T30","span":{"begin":1874,"end":1886},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T31","span":{"begin":2143,"end":2149},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"2 The mononuclear phagocyte system (MPS)\nThe MPS is a dispersed organ, present throughout the body, with distinctive properties in every organ [21]. Tissue resident macrophage populations in the adult derive from embryonic progenitors and differ markedly in phenotype from bone marrow-derived monocytes, which are recruited to tissues in response to increased demand, for instance infection and tissue damage [19]. Monocyte- derived macrophages are the main generators of inflammation in COVID-19 [2,17,18,20,[22], [23], [24]]. These mononuclear phagocytes express a broad repertoire of plasma membrane and intracellular receptors, serving as sensors of micro-organisms, dying cells and soluble products, to mediate recognition, signaling, migration and activation [19]. Monocytes and macrophages are professional phagocytes, utilizing Fc, complement, Toll-like and non-opsonic lectin-like and scavenger receptors for ingestion, but are also highly active biosynthetic and secretory cells, contributing to inflammation, innate and adaptive cellular and humoral immunity and antimicrobial defences [21]. While promoting tissue homeostasis and repair, they also induce tissue injury, the proverbial two-edged sword. They interact readily with other cells through contact and soluble mediators including cytokines, chemokines and enzymes that activate plasma coagulation and complement cascades [24]; in addition, they generate reactive oxygen, nitrogen and arachidonate metabolites implicated in host inflammation and resolution [25]. By analogy with lymphocytes, their activation status is characterized for convenience as M1-type (pro-inflammatory) and M2-type (anti-inflammatory, reparative) [7]. Unlike T and B lymphocytes, mononuclear phagocytes are antigen non-specific, and only display a transient form of memory [26], primed to adapt to secondary challenges such as phagocytosis and microbial stimuli by further activation of potent secretory and cytotoxic pathways [7]. The level of activation covers a spectrum of effector mechanisms, constrained by inhibitory cytokines such as IL-10, IL-1 receptor antagonist [27] and transforming growth factor beta TGF-β, and by anti-inflammatory glucocorticoids and prostaglandins."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T33","span":{"begin":0,"end":41},"obj":"Sentence"},{"id":"T34","span":{"begin":42,"end":149},"obj":"Sentence"},{"id":"T35","span":{"begin":150,"end":415},"obj":"Sentence"},{"id":"T36","span":{"begin":416,"end":528},"obj":"Sentence"},{"id":"T37","span":{"begin":529,"end":771},"obj":"Sentence"},{"id":"T38","span":{"begin":772,"end":1103},"obj":"Sentence"},{"id":"T39","span":{"begin":1104,"end":1214},"obj":"Sentence"},{"id":"T40","span":{"begin":1215,"end":1533},"obj":"Sentence"},{"id":"T41","span":{"begin":1534,"end":1698},"obj":"Sentence"},{"id":"T42","span":{"begin":1699,"end":1978},"obj":"Sentence"},{"id":"T43","span":{"begin":1979,"end":2229},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"2 The mononuclear phagocyte system (MPS)\nThe MPS is a dispersed organ, present throughout the body, with distinctive properties in every organ [21]. Tissue resident macrophage populations in the adult derive from embryonic progenitors and differ markedly in phenotype from bone marrow-derived monocytes, which are recruited to tissues in response to increased demand, for instance infection and tissue damage [19]. Monocyte- derived macrophages are the main generators of inflammation in COVID-19 [2,17,18,20,[22], [23], [24]]. These mononuclear phagocytes express a broad repertoire of plasma membrane and intracellular receptors, serving as sensors of micro-organisms, dying cells and soluble products, to mediate recognition, signaling, migration and activation [19]. Monocytes and macrophages are professional phagocytes, utilizing Fc, complement, Toll-like and non-opsonic lectin-like and scavenger receptors for ingestion, but are also highly active biosynthetic and secretory cells, contributing to inflammation, innate and adaptive cellular and humoral immunity and antimicrobial defences [21]. While promoting tissue homeostasis and repair, they also induce tissue injury, the proverbial two-edged sword. They interact readily with other cells through contact and soluble mediators including cytokines, chemokines and enzymes that activate plasma coagulation and complement cascades [24]; in addition, they generate reactive oxygen, nitrogen and arachidonate metabolites implicated in host inflammation and resolution [25]. By analogy with lymphocytes, their activation status is characterized for convenience as M1-type (pro-inflammatory) and M2-type (anti-inflammatory, reparative) [7]. Unlike T and B lymphocytes, mononuclear phagocytes are antigen non-specific, and only display a transient form of memory [26], primed to adapt to secondary challenges such as phagocytosis and microbial stimuli by further activation of potent secretory and cytotoxic pathways [7]. The level of activation covers a spectrum of effector mechanisms, constrained by inhibitory cytokines such as IL-10, IL-1 receptor antagonist [27] and transforming growth factor beta TGF-β, and by anti-inflammatory glucocorticoids and prostaglandins."}

2_test

{"project":"2_test","denotations":[{"id":"32861199-28662662-26409802","span":{"begin":145,"end":147},"obj":"28662662"},{"id":"32861199-30332628-26409803","span":{"begin":411,"end":413},"obj":"30332628"},{"id":"32861199-32610079-26409804","span":{"begin":499,"end":500},"obj":"32610079"},{"id":"32861199-32534467-26409805","span":{"begin":507,"end":509},"obj":"32534467"},{"id":"32861199-32278362-26409806","span":{"begin":511,"end":513},"obj":"32278362"},{"id":"32861199-32377375-26409807","span":{"begin":517,"end":519},"obj":"32377375"},{"id":"32861199-30332628-26409808","span":{"begin":767,"end":769},"obj":"30332628"},{"id":"32861199-28662662-26409809","span":{"begin":1099,"end":1101},"obj":"28662662"},{"id":"32861199-24669294-26409810","span":{"begin":1695,"end":1696},"obj":"24669294"},{"id":"32861199-24669294-26409811","span":{"begin":1975,"end":1976},"obj":"24669294"}],"text":"2 The mononuclear phagocyte system (MPS)\nThe MPS is a dispersed organ, present throughout the body, with distinctive properties in every organ [21]. Tissue resident macrophage populations in the adult derive from embryonic progenitors and differ markedly in phenotype from bone marrow-derived monocytes, which are recruited to tissues in response to increased demand, for instance infection and tissue damage [19]. Monocyte- derived macrophages are the main generators of inflammation in COVID-19 [2,17,18,20,[22], [23], [24]]. These mononuclear phagocytes express a broad repertoire of plasma membrane and intracellular receptors, serving as sensors of micro-organisms, dying cells and soluble products, to mediate recognition, signaling, migration and activation [19]. Monocytes and macrophages are professional phagocytes, utilizing Fc, complement, Toll-like and non-opsonic lectin-like and scavenger receptors for ingestion, but are also highly active biosynthetic and secretory cells, contributing to inflammation, innate and adaptive cellular and humoral immunity and antimicrobial defences [21]. While promoting tissue homeostasis and repair, they also induce tissue injury, the proverbial two-edged sword. They interact readily with other cells through contact and soluble mediators including cytokines, chemokines and enzymes that activate plasma coagulation and complement cascades [24]; in addition, they generate reactive oxygen, nitrogen and arachidonate metabolites implicated in host inflammation and resolution [25]. By analogy with lymphocytes, their activation status is characterized for convenience as M1-type (pro-inflammatory) and M2-type (anti-inflammatory, reparative) [7]. Unlike T and B lymphocytes, mononuclear phagocytes are antigen non-specific, and only display a transient form of memory [26], primed to adapt to secondary challenges such as phagocytosis and microbial stimuli by further activation of potent secretory and cytotoxic pathways [7]. The level of activation covers a spectrum of effector mechanisms, constrained by inhibitory cytokines such as IL-10, IL-1 receptor antagonist [27] and transforming growth factor beta TGF-β, and by anti-inflammatory glucocorticoids and prostaglandins."}

LitCovid-PMC-OGER-BB

LitCovid-PubTator

MyTest

{"project":"MyTest","denotations":[{"id":"32861199-28662662-26409802","span":{"begin":145,"end":147},"obj":"28662662"},{"id":"32861199-30332628-26409803","span":{"begin":411,"end":413},"obj":"30332628"},{"id":"32861199-32610079-26409804","span":{"begin":499,"end":500},"obj":"32610079"},{"id":"32861199-32534467-26409805","span":{"begin":507,"end":509},"obj":"32534467"},{"id":"32861199-32278362-26409806","span":{"begin":511,"end":513},"obj":"32278362"},{"id":"32861199-32377375-26409807","span":{"begin":517,"end":519},"obj":"32377375"},{"id":"32861199-30332628-26409808","span":{"begin":767,"end":769},"obj":"30332628"},{"id":"32861199-28662662-26409809","span":{"begin":1099,"end":1101},"obj":"28662662"},{"id":"32861199-24669294-26409810","span":{"begin":1695,"end":1696},"obj":"24669294"},{"id":"32861199-24669294-26409811","span":{"begin":1975,"end":1976},"obj":"24669294"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"2 The mononuclear phagocyte system (MPS)\nThe MPS is a dispersed organ, present throughout the body, with distinctive properties in every organ [21]. Tissue resident macrophage populations in the adult derive from embryonic progenitors and differ markedly in phenotype from bone marrow-derived monocytes, which are recruited to tissues in response to increased demand, for instance infection and tissue damage [19]. Monocyte- derived macrophages are the main generators of inflammation in COVID-19 [2,17,18,20,[22], [23], [24]]. These mononuclear phagocytes express a broad repertoire of plasma membrane and intracellular receptors, serving as sensors of micro-organisms, dying cells and soluble products, to mediate recognition, signaling, migration and activation [19]. Monocytes and macrophages are professional phagocytes, utilizing Fc, complement, Toll-like and non-opsonic lectin-like and scavenger receptors for ingestion, but are also highly active biosynthetic and secretory cells, contributing to inflammation, innate and adaptive cellular and humoral immunity and antimicrobial defences [21]. While promoting tissue homeostasis and repair, they also induce tissue injury, the proverbial two-edged sword. They interact readily with other cells through contact and soluble mediators including cytokines, chemokines and enzymes that activate plasma coagulation and complement cascades [24]; in addition, they generate reactive oxygen, nitrogen and arachidonate metabolites implicated in host inflammation and resolution [25]. By analogy with lymphocytes, their activation status is characterized for convenience as M1-type (pro-inflammatory) and M2-type (anti-inflammatory, reparative) [7]. Unlike T and B lymphocytes, mononuclear phagocytes are antigen non-specific, and only display a transient form of memory [26], primed to adapt to secondary challenges such as phagocytosis and microbial stimuli by further activation of potent secretory and cytotoxic pathways [7]. The level of activation covers a spectrum of effector mechanisms, constrained by inhibitory cytokines such as IL-10, IL-1 receptor antagonist [27] and transforming growth factor beta TGF-β, and by anti-inflammatory glucocorticoids and prostaglandins."}

PMC:7456455 / 5075-7304 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7456455 / 5075-7304 JSON TXT