PMC:7456455 / 5075-7304
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T66 | 7-35 | Body_part | denotes | mononuclear phagocyte system | http://purl.org/sig/ont/fma/fma84189 |
T67 | 37-40 | Body_part | denotes | MPS | http://purl.org/sig/ont/fma/fma84189 |
T68 | 46-49 | Body_part | denotes | MPS | http://purl.org/sig/ont/fma/fma84189 |
T69 | 65-70 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
T70 | 95-99 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
T71 | 138-143 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
T72 | 150-176 | Body_part | denotes | Tissue resident macrophage | http://purl.org/sig/ont/fma/fma84644 |
T73 | 150-156 | Body_part | denotes | Tissue | http://purl.org/sig/ont/fma/fma9637 |
T74 | 274-285 | Body_part | denotes | bone marrow | http://purl.org/sig/ont/fma/fma9608 |
T75 | 294-303 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
T76 | 328-335 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T77 | 396-402 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T78 | 416-424 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
T79 | 434-445 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T80 | 535-557 | Body_part | denotes | mononuclear phagocytes | http://purl.org/sig/ont/fma/fma273563 |
T81 | 588-603 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
T82 | 678-683 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T83 | 772-781 | Body_part | denotes | Monocytes | http://purl.org/sig/ont/fma/fma62864 |
T84 | 786-797 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T85 | 984-989 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T86 | 1120-1126 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T87 | 1168-1174 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T88 | 1248-1253 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T89 | 1302-1311 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T90 | 1313-1323 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
T91 | 1350-1356 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
T92 | 1550-1561 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
T93 | 1712-1725 | Body_part | denotes | B lymphocytes | http://purl.org/sig/ont/fma/fma62869 |
T94 | 1727-1749 | Body_part | denotes | mononuclear phagocytes | http://purl.org/sig/ont/fma/fma273563 |
T95 | 2071-2080 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T96 | 2096-2100 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T16 | 65-70 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
T17 | 138-143 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
T18 | 150-156 | Body_part | denotes | Tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T19 | 274-285 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
T20 | 396-402 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T21 | 1120-1126 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T22 | 1168-1174 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T30 | 37-40 | Disease | denotes | MPS | http://purl.obolibrary.org/obo/MONDO_0019249 |
T31 | 46-49 | Disease | denotes | MPS | http://purl.obolibrary.org/obo/MONDO_0019249 |
T32 | 382-391 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T33 | 473-485 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T34 | 489-497 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T35 | 1007-1019 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T36 | 1175-1181 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T37 | 1500-1512 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T95 | 7-28 | http://purl.obolibrary.org/obo/CL_0000113 | denotes | mononuclear phagocyte |
T96 | 53-54 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T97 | 65-70 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
T98 | 138-143 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
T99 | 150-176 | http://purl.obolibrary.org/obo/CL_0000864 | denotes | Tissue resident macrophage |
T100 | 274-278 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | bone |
T101 | 294-303 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
T102 | 416-424 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
T103 | 511-513 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
T104 | 535-557 | http://purl.obolibrary.org/obo/CL_0000113 | denotes | mononuclear phagocytes |
T105 | 566-567 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T106 | 588-594 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T107 | 595-603 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T108 | 661-670 | http://purl.obolibrary.org/obo/OBI_0100026 | denotes | organisms |
T109 | 661-670 | http://purl.obolibrary.org/obo/UBERON_0000468 | denotes | organisms |
T110 | 678-683 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T111 | 730-739 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
T112 | 755-765 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T113 | 772-781 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocytes |
T114 | 815-825 | http://purl.obolibrary.org/obo/CL_0000234 | denotes | phagocytes |
T115 | 837-839 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T116 | 950-956 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T117 | 984-989 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T118 | 1248-1253 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T119 | 1341-1349 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
T120 | 1350-1356 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T121 | 1569-1579 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T122 | 1623-1625 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
T123 | 1623-1625 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
T124 | 1712-1713 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T125 | 1727-1749 | http://purl.obolibrary.org/obo/CL_0000113 | denotes | mononuclear phagocytes |
T126 | 1793-1794 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T127 | 1920-1930 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T128 | 1992-2002 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T129 | 2010-2011 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T130 | 2122-2124 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T15 | 1075-1088 | Chemical | denotes | antimicrobial | http://purl.obolibrary.org/obo/CHEBI_33281 |
T16 | 1435-1441 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
T17 | 1443-1451 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
T18 | 1456-1468 | Chemical | denotes | arachidonate | http://purl.obolibrary.org/obo/CHEBI_32395 |
T19 | 1469-1480 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
T20 | 1623-1625 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
T24 | 1654-1656 | Chemical | denotes | M2 | http://purl.obolibrary.org/obo/CHEBI_34827|http://purl.obolibrary.org/obo/CHEBI_51112 |
T26 | 1754-1761 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T27 | 2024-2032 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
T28 | 2089-2091 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T30 | 2096-2098 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T32 | 2110-2120 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
T33 | 2157-2161 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
T34 | 2194-2209 | Chemical | denotes | glucocorticoids | http://purl.obolibrary.org/obo/CHEBI_24261 |
T35 | 2214-2228 | Chemical | denotes | prostaglandins | http://purl.obolibrary.org/obo/CHEBI_26333 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T20 | 473-485 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T21 | 730-739 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T22 | 1007-1019 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T23 | 1120-1138 | http://purl.obolibrary.org/obo/GO_0001894 | denotes | tissue homeostasis |
T24 | 1127-1138 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
T25 | 1357-1368 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
T26 | 1373-1392 | http://purl.obolibrary.org/obo/GO_0006956 | denotes | complement cascades |
T27 | 1500-1512 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T28 | 1550-1579 | http://purl.obolibrary.org/obo/GO_0046649 | denotes | lymphocytes, their activation |
T29 | 1813-1819 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
T30 | 1874-1886 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
T31 | 2143-2149 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T33 | 0-41 | Sentence | denotes | 2 The mononuclear phagocyte system (MPS) |
T34 | 42-149 | Sentence | denotes | The MPS is a dispersed organ, present throughout the body, with distinctive properties in every organ [21]. |
T35 | 150-415 | Sentence | denotes | Tissue resident macrophage populations in the adult derive from embryonic progenitors and differ markedly in phenotype from bone marrow-derived monocytes, which are recruited to tissues in response to increased demand, for instance infection and tissue damage [19]. |
T36 | 416-528 | Sentence | denotes | Monocyte- derived macrophages are the main generators of inflammation in COVID-19 [2,17,18,20,[22], [23], [24]]. |
T37 | 529-771 | Sentence | denotes | These mononuclear phagocytes express a broad repertoire of plasma membrane and intracellular receptors, serving as sensors of micro-organisms, dying cells and soluble products, to mediate recognition, signaling, migration and activation [19]. |
T38 | 772-1103 | Sentence | denotes | Monocytes and macrophages are professional phagocytes, utilizing Fc, complement, Toll-like and non-opsonic lectin-like and scavenger receptors for ingestion, but are also highly active biosynthetic and secretory cells, contributing to inflammation, innate and adaptive cellular and humoral immunity and antimicrobial defences [21]. |
T39 | 1104-1214 | Sentence | denotes | While promoting tissue homeostasis and repair, they also induce tissue injury, the proverbial two-edged sword. |
T40 | 1215-1533 | Sentence | denotes | They interact readily with other cells through contact and soluble mediators including cytokines, chemokines and enzymes that activate plasma coagulation and complement cascades [24]; in addition, they generate reactive oxygen, nitrogen and arachidonate metabolites implicated in host inflammation and resolution [25]. |
T41 | 1534-1698 | Sentence | denotes | By analogy with lymphocytes, their activation status is characterized for convenience as M1-type (pro-inflammatory) and M2-type (anti-inflammatory, reparative) [7]. |
T42 | 1699-1978 | Sentence | denotes | Unlike T and B lymphocytes, mononuclear phagocytes are antigen non-specific, and only display a transient form of memory [26], primed to adapt to secondary challenges such as phagocytosis and microbial stimuli by further activation of potent secretory and cytotoxic pathways [7]. |
T43 | 1979-2229 | Sentence | denotes | The level of activation covers a spectrum of effector mechanisms, constrained by inhibitory cytokines such as IL-10, IL-1 receptor antagonist [27] and transforming growth factor beta TGF-β, and by anti-inflammatory glucocorticoids and prostaglandins. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32861199-28662662-26409802 | 145-147 | 28662662 | denotes | 21 |
32861199-30332628-26409803 | 411-413 | 30332628 | denotes | 19 |
32861199-32610079-26409804 | 499-500 | 32610079 | denotes | 2 |
32861199-32534467-26409805 | 507-509 | 32534467 | denotes | 20 |
32861199-32278362-26409806 | 511-513 | 32278362 | denotes | 22 |
32861199-32377375-26409807 | 517-519 | 32377375 | denotes | 23 |
32861199-30332628-26409808 | 767-769 | 30332628 | denotes | 19 |
32861199-28662662-26409809 | 1099-1101 | 28662662 | denotes | 21 |
32861199-24669294-26409810 | 1695-1696 | 24669294 | denotes | 7 |
32861199-24669294-26409811 | 1975-1976 | 24669294 | denotes | 7 |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T164 | 7-18 | GO:0005634;CL:0000113 | denotes | mononuclear |
T165 | 19-28 | CL:0000113 | denotes | phagocyte |
T166 | 65-70 | UBERON:0000062 | denotes | organ |
T167 | 138-143 | UBERON:0000062 | denotes | organ |
T168 | 150-156 | UBERON:0000479 | denotes | Tissue |
T169 | 166-176 | CL:0000864 | denotes | macrophage |
T170 | 196-201 | UBERON:0007023 | denotes | adult |
T171 | 214-223 | UBERON:0000922 | denotes | embryonic |
T172 | 274-285 | UBERON:0002371 | denotes | bone marrow |
T173 | 294-303 | CL:0000576 | denotes | monocytes |
T174 | 328-335 | UBERON:0000479 | denotes | tissues |
T175 | 396-402 | UBERON:0000479 | denotes | tissue |
T176 | 416-424 | CL:0000576 | denotes | Monocyte |
T177 | 434-445 | CL:0000235 | denotes | macrophages |
T178 | 489-497 | SP_7 | denotes | COVID-19 |
T179 | 535-546 | GO:0005634;CL:0000113 | denotes | mononuclear |
T180 | 547-557 | CL:0000113 | denotes | phagocytes |
T181 | 558-565 | GO:0010467 | denotes | express |
T182 | 588-603 | GO:0005886 | denotes | plasma membrane |
T183 | 608-621 | GO:0005622 | denotes | intracellular |
T184 | 661-670 | NCBITaxon:1 | denotes | organisms |
T185 | 672-677 | GO:0016265 | denotes | dying |
T186 | 772-781 | CL:0000576 | denotes | Monocytes |
T187 | 786-797 | CL:0000235 | denotes | macrophages |
T188 | 815-825 | CL:0000234 | denotes | phagocytes |
T189 | 974-989 | CL:0000151 | denotes | secretory cells |
T190 | 1021-1027 | GO:0045087 | denotes | innate |
T191 | 1041-1049 | GO:0006968 | denotes | cellular |
T192 | 1075-1088 | CHEBI:67079;CHEBI:67079 | denotes | antimicrobial |
T193 | 1120-1126 | UBERON:0000479;GO:0001894 | denotes | tissue |
T194 | 1127-1138 | GO:0001894 | denotes | homeostasis |
T195 | 1168-1174 | UBERON:0000479 | denotes | tissue |
T196 | 1350-1356 | UBERON:0001969 | denotes | plasma |
T197 | 1357-1368 | GO:0050817 | denotes | coagulation |
T198 | 1373-1392 | GO:0006956 | denotes | complement cascades |
T199 | 1426-1434 | CHEBI:26523;CHEBI:26523 | denotes | reactive |
T200 | 1469-1480 | CHEBI:25212;CHEBI:25212 | denotes | metabolites |
T201 | 1550-1561 | CL:0000542 | denotes | lymphocytes |
T202 | 1706-1707 | CL:0000084 | denotes | T |
T203 | 1712-1725 | CL:0000236 | denotes | B lymphocytes |
T204 | 1727-1738 | GO:0005634;CL:0000113 | denotes | mononuclear |
T205 | 1739-1749 | CL:0000113 | denotes | phagocytes |
T206 | 1754-1761 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T207 | 1813-1819 | GO:0007613 | denotes | memory |
T208 | 1874-1886 | GO:0006909 | denotes | phagocytosis |
T209 | 2024-2032 | CHEBI:35224;CHEBI:35224 | denotes | effector |
T210 | 2089-2094 | PR:000001471 | denotes | IL-10 |
T211 | 2101-2120 | CHEBI:48561;CHEBI:48561 | denotes | receptor antagonist |
T212 | 2130-2167 | PR:000000046 | denotes | transforming growth factor beta TGF-β |
T213 | 2176-2193 | CHEBI:35472;CHEBI:35472 | denotes | anti-inflammatory |
T214 | 2194-2209 | CHEBI:24261;CHEBI:24261 | denotes | glucocorticoids |
T215 | 2214-2228 | CHEBI:26333;CHEBI:26333 | denotes | prostaglandins |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
103 | 37-40 | Disease | denotes | MPS | MESH:D009084 |
117 | 2089-2094 | Gene | denotes | IL-10 | Gene:3586 |
118 | 2096-2120 | Gene | denotes | IL-1 receptor antagonist | Gene:3557 |
119 | 2162-2167 | Gene | denotes | TGF-β | Gene:7039 |
120 | 1435-1441 | Chemical | denotes | oxygen | MESH:D010100 |
121 | 1443-1451 | Chemical | denotes | nitrogen | MESH:D009584 |
122 | 1456-1468 | Chemical | denotes | arachidonate | MESH:D016718 |
123 | 2214-2228 | Chemical | denotes | prostaglandins | MESH:D011453 |
124 | 46-49 | Disease | denotes | MPS | MESH:D009084 |
125 | 382-391 | Disease | denotes | infection | MESH:D007239 |
126 | 473-485 | Disease | denotes | inflammation | MESH:D007249 |
127 | 489-497 | Disease | denotes | COVID-19 | MESH:C000657245 |
128 | 1007-1019 | Disease | denotes | inflammation | MESH:D007249 |
129 | 1500-1512 | Disease | denotes | inflammation | MESH:D007249 |
MyTest
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32861199-28662662-26409802 | 145-147 | 28662662 | denotes | 21 |
32861199-30332628-26409803 | 411-413 | 30332628 | denotes | 19 |
32861199-32610079-26409804 | 499-500 | 32610079 | denotes | 2 |
32861199-32534467-26409805 | 507-509 | 32534467 | denotes | 20 |
32861199-32278362-26409806 | 511-513 | 32278362 | denotes | 22 |
32861199-32377375-26409807 | 517-519 | 32377375 | denotes | 23 |
32861199-30332628-26409808 | 767-769 | 30332628 | denotes | 19 |
32861199-28662662-26409809 | 1099-1101 | 28662662 | denotes | 21 |
32861199-24669294-26409810 | 1695-1696 | 24669294 | denotes | 7 |
32861199-24669294-26409811 | 1975-1976 | 24669294 | denotes | 7 |