PMC:7456455 / 26887-28156
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T350 | 252-260 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T351 | 269-280 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T352 | 284-291 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T353 | 315-324 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T354 | 500-504 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T355 | 790-798 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T356 | 865-874 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T357 | 914-922 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T358 | 960-968 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T359 | 1071-1077 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T360 | 1112-1120 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T361 | 1196-1201 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T362 | 1209-1217 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T363 | 1245-1255 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T87 | 1071-1077 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T181 | 564-572 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T182 | 573-582 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T183 | 728-736 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T184 | 737-746 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T185 | 991-1000 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T386 | 45-55 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T387 | 206-207 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T388 | 238-248 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T389 | 252-260 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T390 | 315-324 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T391 | 335-345 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T392 | 477-479 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
| T393 | 477-479 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
| T394 | 488-498 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T395 | 500-504 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T396 | 620-621 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T397 | 631-641 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T398 | 687-694 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T399 | 774-775 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T400 | 790-798 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T401 | 799-809 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T402 | 865-874 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T403 | 914-922 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
| T404 | 923-928 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
| T405 | 969-974 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
| T406 | 1112-1120 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T407 | 1121-1131 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T408 | 1145-1151 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T409 | 1196-1201 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T146 | 477-479 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
| T150 | 480-482 | Chemical | denotes | M2 | http://purl.obolibrary.org/obo/CHEBI_34827|http://purl.obolibrary.org/obo/CHEBI_51112 |
| T152 | 1078-1086 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T153 | 1209-1217 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T154 | 1219-1235 | Chemical | denotes | antiviral agents | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T120 | 315-345 | http://purl.obolibrary.org/obo/GO_0042117 | denotes | monocytes and their activation |
| T121 | 393-397 | http://purl.obolibrary.org/obo/GO_0005011 | denotes | CSF1 |
| T122 | 433-439 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T123 | 500-515 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T124 | 790-809 | http://purl.obolibrary.org/obo/GO_0042117 | denotes | monocyte activation |
| T125 | 878-890 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T126 | 1112-1131 | http://purl.obolibrary.org/obo/GO_0042117 | denotes | monocyte activation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T161 | 0-120 | Sentence | denotes | The balance of pro- versus anti-inflammatory activation determines the protective versus deleterious impact on the host. |
| T162 | 121-300 | Sentence | denotes | In vivo priming, combined with innate and adaptive immune triggers in vitro, provide a surrogate assay for potential activation of monocyte-derived macrophages in tissues, Fig. 1. |
| T163 | 301-667 | Sentence | denotes | The number of monocytes and their activation status can be assayed by combining analysis of CSF1-, CSF2- and CSF3- receptors during growth and differentiation, with markers of M1/M2-like activation; gene expression biomarkers are available at different stages of COVID-19 infection for each pathway, and in response to a range of activating and deactivating stimuli. |
| T164 | 668-816 | Sentence | denotes | Fig. 2 illustrates testing points in the natural history of COVID-19 infection and lists requirements for a comprehensive monocyte activation assay. |
| T165 | 817-913 | Sentence | denotes | This provides insights into the contribution of monocytes to pathogenesis, and guides treatment. |
| T166 | 914-1097 | Sentence | denotes | Monocyte tests can be combined with viral and antibody tests at any stage of infection, providing access to an intermediate stage between haematopoiesis and tissue effector functions. |
| T167 | 1098-1269 | Sentence | denotes | Regulators of monocyte activation which can be tested in vitro include innate and adaptive immune cells, viral proteins, antiviral agents and anti-macrophage therapeutics. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T710 | 163-171 | GO:0045087 | denotes | adaptive |
| T711 | 172-178 | GO:0045087;UBERON:0002405 | denotes | immune |
| T712 | 252-260 | CL:0000576 | denotes | monocyte |
| T713 | 269-280 | CL:0000235 | denotes | macrophages |
| T714 | 284-291 | UBERON:0000479 | denotes | tissues |
| T715 | 315-324 | CL:0000576 | denotes | monocytes |
| T716 | 393-397 | PR:000005930 | denotes | CSF1 |
| T717 | 400-404 | PR:000005931 | denotes | CSF2 |
| T718 | 410-414 | PR:000005932 | denotes | CSF3 |
| T719 | 500-504 | SO:0000704;GO:0010467 | denotes | gene |
| T720 | 505-515 | GO:0010467 | denotes | expression |
| T721 | 564-572 | SP_7 | denotes | COVID-19 |
| T722 | 728-736 | SP_7 | denotes | COVID-19 |
| T723 | 790-798 | CL:0000576 | denotes | monocyte |
| T724 | 865-874 | CL:0000576 | denotes | monocytes |
| T725 | 914-922 | CL:0000576 | denotes | Monocyte |
| T726 | 950-955 | NCBITaxon:10239 | denotes | viral |
| T727 | 960-968 | GO:0042571 | denotes | antibody |
| T728 | 1052-1066 | GO:0030097 | denotes | haematopoiesis |
| T729 | 1071-1077 | UBERON:0000479 | denotes | tissue |
| T730 | 1078-1086 | CHEBI:35224;CHEBI:35224 | denotes | effector |
| T731 | 1112-1120 | CL:0000576;GO:0042117 | denotes | monocyte |
| T732 | 1121-1131 | GO:0042117 | denotes | activation |
| T733 | 1189-1195 | UBERON:0002405;CL:0000738 | denotes | immune |
| T734 | 1196-1201 | CL:0000738 | denotes | cells |
| T735 | 1203-1208 | NCBITaxon:10239 | denotes | viral |
| T736 | 1219-1235 | CHEBI:67079;CHEBI:67079 | denotes | antiviral agents |
| T737 | 1245-1255 | CL:0000235 | denotes | macrophage |
| T100 | 1052-1066 | GO:0030097 | denotes | haematopoiesis |
| T44099 | 17-21 | PR:000005930 | denotes | o- v |
| T14950 | 24-28 | PR:000005931 | denotes | us a |
| T92219 | 34-38 | PR:000005932 | denotes | flam |
| T79334 | 124-128 | SO:0000704;GO:0010467 | denotes | vivo |
| T79721 | 129-139 | GO:0010467 | denotes | priming, c |
| T60271 | 189-197 | SP_7 | denotes | n vitro, |
| T41374 | 353-361 | SP_7 | denotes | can be a |
| T56149 | 415-423 | CL:0000576 | denotes | recepto |
| T30588 | 490-499 | CL:0000576 | denotes | tivation; |
| T23587 | 539-547 | CL:0000576 | denotes | e at dif |
| T56472 | 575-580 | NCBITaxon:10239 | denotes | fecti |
| T41778 | 585-593 | GO:0042571 | denotes | r each p |
| T1076 | 678-692 | GO:0030097 | denotes | ustrates testi |
| T33032 | 697-703 | UBERON:0000479 | denotes | ints i |
| T64351 | 704-712 | CHEBI:35224;CHEBI:35224 | denotes | the nat |
| T29973 | 738-746 | CL:0000576;GO:0042117 | denotes | nfection |
| T56526 | 747-757 | GO:0042117 | denotes | and lists |
| T67771 | 815-820 | UBERON:0002405;CL:0000738 | denotes | . Thi |
| T98374 | 821-826 | CL:0000738 | denotes | prov |
| T64816 | 828-833 | NCBITaxon:10239 | denotes | es in |
| T12719 | 844-860 | CHEBI:67079;CHEBI:67079 | denotes | the contributio |
| T26219 | 870-880 | CL:0000235 | denotes | ytes to pa |
| T73107 | 946-951 | NCBITaxon:10239 | denotes | ith v |
| T82998 | 1078-1088 | CL:0000542 | denotes | effector f |
| T13763 | 1116-1126 | NCBITaxon:11632 | denotes | cyte activ |
| T90599 | 1161-1169 | GO:0042571 | denotes | include |
| T39412 | 1202-1212 | NCBITaxon:31032 | denotes | viral pro |
| T4838 | 1260-1268 | SP_7 | denotes | apeutics |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 648 | 393-397 | Gene | denotes | CSF1 | Gene:1435 |
| 649 | 400-404 | Gene | denotes | CSF2 | Gene:1437 |
| 650 | 410-414 | Gene | denotes | CSF3 | Gene:1440 |
| 651 | 564-572 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 652 | 573-582 | Disease | denotes | infection | MESH:D007239 |
| 653 | 728-736 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 654 | 737-746 | Disease | denotes | infection | MESH:D007239 |
| 655 | 991-1000 | Disease | denotes | infection | MESH:D007239 |