PMC:7454258 / 114800-122153 JSONTXT

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the science for dietary recommendations to the public Comparative effects of different popular diet patterns, eating frequency, intermittent fasting, and diet quantity vs. different foods on weight loss and weight maintenance; and heterogeneity in these effects based on a person's characteristics\nOptimal dietary recommendations for specific disease conditions, such as hypertension, type 2 diabetes, cardiovascular diseases, specific cancers, infections, autoimmune diseases, and more\nRigorous studies on food groups with unclear or controversial evidence, such as different dairy foods (cheese, yogurt, milk, butter), red meats, tropical oils, organic vs. nonorganic foods, among others\nNumerous other critical areas requiring more scientific evidence as identified by the 2015 DGAC (see Supplemental Table 2)\nA stronger intergovernmental process and more consistent funding for establishing DGAs and DRIs\nLeverage new technologies and data science resources and approaches Interactions between diet, the gut microbiome, immunity, epigenetics, vascular health, and other physiological systems\nPersonalized or precision nutrition, including based on personal backgrounds, habits, genes, microbiomes, medications, and chronic medical conditions\nInterrelationships of nutrition and epigenetics for health\nUsing innovative technology and data science for diverse fundamental, clinical, environmental, and public health research questions in food and nutrition\nAdvance foundational and basic science knowledge and discoveries Molecular basis of nutritional needs across the lifespan, physical activity levels, and disease conditions\nPathways of nutritional effects in the first 1000 days of life for programming of lifelong health\nOrigins of and treatments for food allergies\nOptimal nutrition for healthy aging\nNutritional treatments for reducing side effects of and more effectively targeting cancer chemo- and radiation therapy\nComprehensive characterization of and molecular and 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to children\nStrengthen medical nutrition therapy for an array of acute and chronic diseases and conditions\nCoordinated interagency research on Food is Medicine interventions within health care systems, including medical and other allied health professional education, medically tailored meals with enhanced medical nutrition therapy, produce prescriptions, and other nutrition-focused flexible benefit services\nCoordinate key cross-agency research priorities for nutrition-related investments Optimizing nutrition-related investments for diplomacy, development, and defense, such as by USAID ($27 billion/y)\nDoD priorities around nutrition for human performance, military readiness, and treatment of musculoskeletal and battlefield injuries\nVHA opportunities to reduce high rates of diet-related illnesses among veterans\nUnderstand and define basic nutrient requirements during extended stays in microgravity, among other research and translation needs to support NASA astronauts\nStrengthen and leverage the nearly $100 billion/y national investment across ≥15 USDA nutrition assistance programs\nFood safety research, relevant to FDA, USDA, and NIH\nFDA regulatory issues including Nutrition Facts labeling, front-of-pack labeling, restaurant menu labeling, health claims, food category standards of identity, cellular agriculture, food additives, and dietary supplements\nIntersections of nutrition science and food, nutrition, and health regulatory activities coordinated between FDA, USDA, NIH, among others\nIntersections with food production, supply chains, and sustainability Interplay of livestock and farming practices on the joint nutritional quality of foods and natural resource use\nNutritional innovations and collaborations for healthier crops and manufactured food products including novel ingredients and biofortification as a means to increase nutrient content and availability\nNutritional implications of novel regenerative agriculture approaches\nImpacts of plant-based 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