PMC:7445716 / 49967-50852 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T311","span":{"begin":19,"end":24},"obj":"Body_part"},{"id":"T312","span":{"begin":227,"end":238},"obj":"Body_part"},{"id":"T313","span":{"begin":348,"end":351},"obj":"Body_part"},{"id":"T314","span":{"begin":430,"end":437},"obj":"Body_part"},{"id":"T315","span":{"begin":450,"end":454},"obj":"Body_part"},{"id":"T316","span":{"begin":464,"end":469},"obj":"Body_part"},{"id":"T317","span":{"begin":475,"end":480},"obj":"Body_part"},{"id":"T318","span":{"begin":482,"end":485},"obj":"Body_part"},{"id":"T319","span":{"begin":486,"end":493},"obj":"Body_part"},{"id":"T320","span":{"begin":636,"end":641},"obj":"Body_part"},{"id":"T321","span":{"begin":726,"end":732},"obj":"Body_part"},{"id":"T322","span":{"begin":807,"end":813},"obj":"Body_part"}],"attributes":[{"id":"A311","pred":"fma_id","subj":"T311","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A312","pred":"fma_id","subj":"T312","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A313","pred":"fma_id","subj":"T313","obj":"http://purl.org/sig/ont/fma/fma62873"},{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A316","pred":"fma_id","subj":"T316","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma20935"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma32558"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T142","span":{"begin":19,"end":24},"obj":"Body_part"},{"id":"T143","span":{"begin":475,"end":480},"obj":"Body_part"},{"id":"T144","span":{"begin":636,"end":641},"obj":"Body_part"}],"attributes":[{"id":"A142","pred":"uberon_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A143","pred":"uberon_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A144","pred":"uberon_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T509","span":{"begin":295,"end":304},"obj":"Disease"},{"id":"T510","span":{"begin":367,"end":387},"obj":"Disease"},{"id":"T511","span":{"begin":392,"end":413},"obj":"Disease"},{"id":"T512","span":{"begin":518,"end":526},"obj":"Disease"},{"id":"T513","span":{"begin":548,"end":556},"obj":"Disease"},{"id":"T514","span":{"begin":676,"end":680},"obj":"Disease"}],"attributes":[{"id":"A509","pred":"mondo_id","subj":"T509","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A510","pred":"mondo_id","subj":"T510","obj":"http://purl.obolibrary.org/obo/MONDO_0025598"},{"id":"A511","pred":"mondo_id","subj":"T511","obj":"http://purl.obolibrary.org/obo/MONDO_0005867"},{"id":"A512","pred":"mondo_id","subj":"T512","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A513","pred":"mondo_id","subj":"T513","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A514","pred":"mondo_id","subj":"T514","obj":"http://purl.obolibrary.org/obo/MONDO_0020347"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T353","span":{"begin":19,"end":24},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T354","span":{"begin":227,"end":238},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T355","span":{"begin":261,"end":265},"obj":"http://purl.obolibrary.org/obo/CLO_0051422"},{"id":"T356","span":{"begin":305,"end":310},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T357","span":{"begin":311,"end":312},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T358","span":{"begin":313,"end":314},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T359","span":{"begin":338,"end":343},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T360","span":{"begin":450,"end":454},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T361","span":{"begin":464,"end":469},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T362","span":{"begin":636,"end":641},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T363","span":{"begin":636,"end":641},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T364","span":{"begin":726,"end":732},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T365","span":{"begin":807,"end":813},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T366","span":{"begin":807,"end":813},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T367","span":{"begin":807,"end":813},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T368","span":{"begin":807,"end":813},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T48282","span":{"begin":430,"end":437},"obj":"Chemical"},{"id":"T15872","span":{"begin":486,"end":493},"obj":"Chemical"}],"attributes":[{"id":"A60664","pred":"chebi_id","subj":"T48282","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A61665","pred":"chebi_id","subj":"T15872","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A27551","pred":"chebi_id","subj":"T15872","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T12","span":{"begin":601,"end":610},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T13","span":{"begin":733,"end":741},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PubTator","denotations":[{"id":"669","span":{"begin":99,"end":102},"obj":"Gene"},{"id":"749","span":{"begin":294,"end":309},"obj":"Species"},{"id":"750","span":{"begin":312,"end":342},"obj":"Species"},{"id":"751","span":{"begin":366,"end":386},"obj":"Species"},{"id":"752","span":{"begin":391,"end":412},"obj":"Species"},{"id":"753","span":{"begin":517,"end":527},"obj":"Species"},{"id":"815","span":{"begin":289,"end":292},"obj":"Species"},{"id":"816","span":{"begin":547,"end":557},"obj":"Species"},{"id":"834","span":{"begin":485,"end":492},"obj":"Chemical"}],"attributes":[{"id":"A669","pred":"tao:has_database_id","subj":"669","obj":"Gene:1401"},{"id":"A749","pred":"tao:has_database_id","subj":"749","obj":"Tax:11308"},{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"Tax:11246"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Tax:83558"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Tax:2104"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"Tax:2697049"},{"id":"A815","pred":"tao:has_database_id","subj":"815","obj":"Tax:10376"},{"id":"A816","pred":"tao:has_database_id","subj":"816","obj":"Tax:2697049"},{"id":"A834","pred":"tao:has_database_id","subj":"834","obj":"MESH:D005947"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-sentences","denotations":[{"id":"T274","span":{"begin":0,"end":85},"obj":"Sentence"},{"id":"T275","span":{"begin":86,"end":123},"obj":"Sentence"},{"id":"T276","span":{"begin":124,"end":175},"obj":"Sentence"},{"id":"T277","span":{"begin":176,"end":212},"obj":"Sentence"},{"id":"T278","span":{"begin":213,"end":461},"obj":"Sentence"},{"id":"T279","span":{"begin":462,"end":675},"obj":"Sentence"},{"id":"T280","span":{"begin":676,"end":885},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T673","span":{"begin":377,"end":387},"obj":"Phenotype"},{"id":"T674","span":{"begin":403,"end":413},"obj":"Phenotype"},{"id":"T675","span":{"begin":643,"end":656},"obj":"Phenotype"}],"attributes":[{"id":"A673","pred":"hp_id","subj":"T673","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A674","pred":"hp_id","subj":"T674","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A675","pred":"hp_id","subj":"T675","obj":"http://purl.obolibrary.org/obo/HP_0011096"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T560","span":{"begin":140,"end":150},"obj":"GO:0005577"},{"id":"T561","span":{"begin":227,"end":238},"obj":"CL:0000232"},{"id":"T562","span":{"begin":285,"end":288},"obj":"NCBITaxon:10358"},{"id":"T563","span":{"begin":290,"end":293},"obj":"NCBITaxon:10376"},{"id":"T564","span":{"begin":295,"end":304},"obj":"NCBITaxon:7719"},{"id":"T565","span":{"begin":305,"end":310},"obj":"NCBITaxon:10376"},{"id":"T566","span":{"begin":316,"end":327},"obj":"NCBITaxon:12814"},{"id":"T567","span":{"begin":338,"end":343},"obj":"NCBITaxon:10376"},{"id":"T568","span":{"begin":348,"end":362},"obj":"GO:0071754"},{"id":"T569","span":{"begin":367,"end":376},"obj":"NCBITaxon:7719"},{"id":"T570","span":{"begin":377,"end":387},"obj":"NCBITaxon:83558"},{"id":"T571","span":{"begin":475,"end":480},"obj":"UBERON:0001977"},{"id":"T572","span":{"begin":486,"end":493},"obj":"CHEBI:17234;CHEBI:17234"},{"id":"T573","span":{"begin":518,"end":528},"obj":"SP_7"},{"id":"T574","span":{"begin":548,"end":558},"obj":"SP_7"},{"id":"T575","span":{"begin":559,"end":569},"obj":"GO:0042571"},{"id":"T576","span":{"begin":636,"end":641},"obj":"UBERON:0000178"},{"id":"T577","span":{"begin":726,"end":732},"obj":"UBERON:0001969;GO:0007585"},{"id":"T578","span":{"begin":733,"end":741},"obj":"GO:0007585"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}

{"project":"2_test","denotations":[{"id":"32840686-32558002-63205769","span":{"begin":14,"end":16},"obj":"32558002"}],"text":"Helbok et al. [24] Chest CT + serology (repeated negative RT-PCR) WBC 8.1G/L (normal: 4.0–10.0G/L), CRP 2.3 mg/dL, (normal: 0.0–0.5 mg/dL), fibrinogen level 650 mg/dL (normal: 210–400 mg/dL), LDH 276 U/L (normal: 100–250 U/L), erythrocyte sedimentation rate 55 mm/1 h Negative PCR for CMV, EBV, influenza virus A/B, Respiratory Syncytial Virus and IgM antibodies for Chlamydia pneumoniae and Mycoplasma pneumoniae Increased total protein (64 mg/dl), cell count: 2 cells/mm3, serum/ CSF glucose ratio of 0.83, negative SARS-CoV-2 PCR, positive anti-SARS-CoV-2 antibodies (not determined if intrathecal synthesis or passive transfer from blood) Demyelinating with sural sparing\nAIDP Spinal: no pathological findings IVIG 30 g + plasma exchange (4 cycles) + mechanical invasive ventilation None Improvement of muscle forces with recovery of mobility without significant help after 8 weeks"}