PMC:7445677 / 10808-12397 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":324,"end":327},"obj":"Body_part"},{"id":"T13","span":{"begin":424,"end":427},"obj":"Body_part"},{"id":"T14","span":{"begin":653,"end":656},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma55675"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T10","span":{"begin":324,"end":327},"obj":"Body_part"},{"id":"T11","span":{"begin":424,"end":427},"obj":"Body_part"},{"id":"T12","span":{"begin":653,"end":656},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T105","span":{"begin":28,"end":36},"obj":"Disease"},{"id":"T106","span":{"begin":221,"end":229},"obj":"Disease"},{"id":"T107","span":{"begin":230,"end":239},"obj":"Disease"},{"id":"T108","span":{"begin":328,"end":336},"obj":"Disease"},{"id":"T109","span":{"begin":339,"end":355},"obj":"Disease"},{"id":"T110","span":{"begin":407,"end":415},"obj":"Disease"},{"id":"T111","span":{"begin":428,"end":437},"obj":"Disease"},{"id":"T112","span":{"begin":477,"end":497},"obj":"Disease"},{"id":"T113","span":{"begin":569,"end":577},"obj":"Disease"},{"id":"T114","span":{"begin":628,"end":636},"obj":"Disease"},{"id":"T115","span":{"begin":733,"end":741},"obj":"Disease"},{"id":"T116","span":{"begin":758,"end":766},"obj":"Disease"},{"id":"T117","span":{"begin":862,"end":870},"obj":"Disease"},{"id":"T118","span":{"begin":937,"end":945},"obj":"Disease"},{"id":"T119","span":{"begin":946,"end":955},"obj":"Disease"},{"id":"T120","span":{"begin":1024,"end":1032},"obj":"Disease"},{"id":"T121","span":{"begin":1131,"end":1139},"obj":"Disease"},{"id":"T122","span":{"begin":1143,"end":1151},"obj":"Disease"},{"id":"T123","span":{"begin":1209,"end":1217},"obj":"Disease"},{"id":"T124","span":{"begin":1334,"end":1342},"obj":"Disease"},{"id":"T125","span":{"begin":1486,"end":1494},"obj":"Disease"},{"id":"T126","span":{"begin":1495,"end":1504},"obj":"Disease"},{"id":"T127","span":{"begin":1525,"end":1533},"obj":"Disease"},{"id":"T128","span":{"begin":1548,"end":1556},"obj":"Disease"}],"attributes":[{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0005071"},{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0005027"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0005027"},{"id":"A118","pred":"mondo_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0005027"},{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A122","pred":"mondo_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/MONDO_0005027"},{"id":"A123","pred":"mondo_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/MONDO_0005027"},{"id":"A124","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A125","pred":"mondo_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A127","pred":"mondo_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/MONDO_0005027"},{"id":"A128","pred":"mondo_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T78","span":{"begin":324,"end":327},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T79","span":{"begin":324,"end":327},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T80","span":{"begin":324,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T81","span":{"begin":339,"end":344},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T82","span":{"begin":378,"end":379},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T83","span":{"begin":418,"end":423},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T84","span":{"begin":424,"end":427},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T85","span":{"begin":424,"end":427},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T86","span":{"begin":424,"end":427},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T87","span":{"begin":446,"end":447},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T88","span":{"begin":640,"end":645},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T89","span":{"begin":653,"end":656},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T90","span":{"begin":653,"end":656},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T91","span":{"begin":653,"end":656},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T92","span":{"begin":810,"end":818},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T93","span":{"begin":836,"end":837},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T94","span":{"begin":1093,"end":1094},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T95","span":{"begin":1352,"end":1353},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"TEST0","denotations":[{"id":"32833573-126-132-3982","span":{"begin":498,"end":500},"obj":"[\"32416028\"]"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"LitCovid-PubTator","denotations":[{"id":"442","span":{"begin":328,"end":338},"obj":"Species"},{"id":"443","span":{"begin":407,"end":417},"obj":"Species"},{"id":"444","span":{"begin":628,"end":636},"obj":"Species"},{"id":"445","span":{"begin":28,"end":36},"obj":"Disease"},{"id":"446","span":{"begin":47,"end":73},"obj":"Disease"},{"id":"447","span":{"begin":182,"end":190},"obj":"Disease"},{"id":"448","span":{"begin":221,"end":229},"obj":"Disease"},{"id":"449","span":{"begin":230,"end":239},"obj":"Disease"},{"id":"450","span":{"begin":345,"end":355},"obj":"Disease"},{"id":"451","span":{"begin":362,"end":370},"obj":"Disease"},{"id":"452","span":{"begin":428,"end":437},"obj":"Disease"},{"id":"453","span":{"begin":477,"end":497},"obj":"Disease"},{"id":"454","span":{"begin":528,"end":552},"obj":"Disease"},{"id":"455","span":{"begin":569,"end":577},"obj":"Disease"},{"id":"482","span":{"begin":767,"end":775},"obj":"Species"},{"id":"483","span":{"begin":822,"end":830},"obj":"Species"},{"id":"484","span":{"begin":1152,"end":1160},"obj":"Species"},{"id":"485","span":{"begin":1453,"end":1461},"obj":"Species"},{"id":"486","span":{"begin":1534,"end":1542},"obj":"Species"},{"id":"487","span":{"begin":717,"end":725},"obj":"Disease"},{"id":"488","span":{"begin":733,"end":741},"obj":"Disease"},{"id":"489","span":{"begin":758,"end":766},"obj":"Disease"},{"id":"490","span":{"begin":849,"end":857},"obj":"Disease"},{"id":"491","span":{"begin":862,"end":870},"obj":"Disease"},{"id":"492","span":{"begin":937,"end":945},"obj":"Disease"},{"id":"493","span":{"begin":946,"end":955},"obj":"Disease"},{"id":"494","span":{"begin":964,"end":972},"obj":"Disease"},{"id":"495","span":{"begin":1008,"end":1016},"obj":"Disease"},{"id":"496","span":{"begin":1024,"end":1032},"obj":"Disease"},{"id":"497","span":{"begin":1131,"end":1139},"obj":"Disease"},{"id":"498","span":{"begin":1143,"end":1151},"obj":"Disease"},{"id":"499","span":{"begin":1196,"end":1204},"obj":"Disease"},{"id":"500","span":{"begin":1209,"end":1217},"obj":"Disease"},{"id":"501","span":{"begin":1260,"end":1268},"obj":"Disease"},{"id":"502","span":{"begin":1334,"end":1342},"obj":"Disease"},{"id":"503","span":{"begin":1486,"end":1494},"obj":"Disease"},{"id":"504","span":{"begin":1495,"end":1504},"obj":"Disease"},{"id":"505","span":{"begin":1525,"end":1533},"obj":"Disease"},{"id":"506","span":{"begin":1548,"end":1556},"obj":"Disease"},{"id":"507","span":{"begin":1580,"end":1588},"obj":"Disease"}],"attributes":[{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Tax:2697049"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Tax:2697049"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Tax:694009"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"MESH:C000657245"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"MESH:D002493"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"MESH:D012640"},{"id":"A448","pred":"tao:has_database_id","subj":"448","obj":"MESH:C000657245"},{"id":"A449","pred":"tao:has_database_id","subj":"449","obj":"MESH:D007239"},{"id":"A450","pred":"tao:has_database_id","subj":"450","obj":"MESH:D007239"},{"id":"A451","pred":"tao:has_database_id","subj":"451","obj":"MESH:D012640"},{"id":"A452","pred":"tao:has_database_id","subj":"452","obj":"MESH:D007239"},{"id":"A453","pred":"tao:has_database_id","subj":"453","obj":"MESH:D020271"},{"id":"A454","pred":"tao:has_database_id","subj":"454","obj":"MESH:D009422"},{"id":"A455","pred":"tao:has_database_id","subj":"455","obj":"MESH:C000657245"},{"id":"A482","pred":"tao:has_database_id","subj":"482","obj":"Tax:9606"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"Tax:9606"},{"id":"A484","pred":"tao:has_database_id","subj":"484","obj":"Tax:9606"},{"id":"A485","pred":"tao:has_database_id","subj":"485","obj":"Tax:9606"},{"id":"A486","pred":"tao:has_database_id","subj":"486","obj":"Tax:9606"},{"id":"A487","pred":"tao:has_database_id","subj":"487","obj":"MESH:D012640"},{"id":"A488","pred":"tao:has_database_id","subj":"488","obj":"MESH:D004827"},{"id":"A489","pred":"tao:has_database_id","subj":"489","obj":"MESH:C000657245"},{"id":"A490","pred":"tao:has_database_id","subj":"490","obj":"MESH:D012640"},{"id":"A491","pred":"tao:has_database_id","subj":"491","obj":"MESH:D004827"},{"id":"A492","pred":"tao:has_database_id","subj":"492","obj":"MESH:C000657245"},{"id":"A493","pred":"tao:has_database_id","subj":"493","obj":"MESH:D007239"},{"id":"A494","pred":"tao:has_database_id","subj":"494","obj":"MESH:D012640"},{"id":"A495","pred":"tao:has_database_id","subj":"495","obj":"MESH:D012640"},{"id":"A496","pred":"tao:has_database_id","subj":"496","obj":"MESH:D004827"},{"id":"A497","pred":"tao:has_database_id","subj":"497","obj":"MESH:C000657245"},{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"MESH:D004827"},{"id":"A499","pred":"tao:has_database_id","subj":"499","obj":"MESH:D012640"},{"id":"A500","pred":"tao:has_database_id","subj":"500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reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"LitCovid-sentences","denotations":[{"id":"T70","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T71","span":{"begin":8,"end":112},"obj":"Sentence"},{"id":"T72","span":{"begin":113,"end":371},"obj":"Sentence"},{"id":"T73","span":{"begin":372,"end":659},"obj":"Sentence"},{"id":"T74","span":{"begin":660,"end":871},"obj":"Sentence"},{"id":"T75","span":{"begin":872,"end":1161},"obj":"Sentence"},{"id":"T76","span":{"begin":1162,"end":1368},"obj":"Sentence"},{"id":"T77","span":{"begin":1369,"end":1589},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T86","span":{"begin":170,"end":190},"obj":"Phenotype"},{"id":"T87","span":{"begin":362,"end":370},"obj":"Phenotype"},{"id":"T88","span":{"begin":717,"end":725},"obj":"Phenotype"},{"id":"T89","span":{"begin":733,"end":741},"obj":"Phenotype"},{"id":"T90","span":{"begin":849,"end":857},"obj":"Phenotype"},{"id":"T91","span":{"begin":862,"end":870},"obj":"Phenotype"},{"id":"T92","span":{"begin":964,"end":972},"obj":"Phenotype"},{"id":"T93","span":{"begin":1008,"end":1016},"obj":"Phenotype"},{"id":"T94","span":{"begin":1024,"end":1032},"obj":"Phenotype"},{"id":"T95","span":{"begin":1143,"end":1151},"obj":"Phenotype"},{"id":"T96","span":{"begin":1196,"end":1204},"obj":"Phenotype"},{"id":"T97","span":{"begin":1209,"end":1217},"obj":"Phenotype"},{"id":"T98","span":{"begin":1260,"end":1268},"obj":"Phenotype"},{"id":"T99","span":{"begin":1525,"end":1533},"obj":"Phenotype"},{"id":"T100","span":{"begin":1580,"end":1588},"obj":"Phenotype"}],"attributes":[{"id":"A86","pred":"hp_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/HP_0011145"},{"id":"A87","pred":"hp_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A88","pred":"hp_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A89","pred":"hp_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A90","pred":"hp_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A91","pred":"hp_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A92","pred":"hp_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A93","pred":"hp_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A94","pred":"hp_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A95","pred":"hp_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A96","pred":"hp_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A97","pred":"hp_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A98","pred":"hp_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A99","pred":"hp_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A100","pred":"hp_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/HP_0001250"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"0_colil","denotations":[{"id":"32833573-32416028-3982","span":{"begin":498,"end":500},"obj":"32416028"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"2_test","denotations":[{"id":"32833573-32416028-28640892","span":{"begin":498,"end":500},"obj":"32416028"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T106","span":{"begin":28,"end":36},"obj":"SP_7"},{"id":"T107","span":{"begin":47,"end":59},"obj":"UBERON:0001016"},{"id":"T108","span":{"begin":221,"end":229},"obj":"SP_7"},{"id":"T109","span":{"begin":324,"end":327},"obj":"UBERON:0001017"},{"id":"T110","span":{"begin":328,"end":338},"obj":"SP_7"},{"id":"T111","span":{"begin":339,"end":344},"obj":"NCBITaxon:10239"},{"id":"T112","span":{"begin":407,"end":417},"obj":"SP_7"},{"id":"T113","span":{"begin":418,"end":423},"obj":"NCBITaxon:10239"},{"id":"T114","span":{"begin":424,"end":427},"obj":"UBERON:0001017"},{"id":"T115","span":{"begin":477,"end":489},"obj":"UBERON:0001016"},{"id":"T116","span":{"begin":528,"end":540},"obj":"UBERON:0001016"},{"id":"T117","span":{"begin":569,"end":577},"obj":"SP_7"},{"id":"T118","span":{"begin":628,"end":636},"obj":"SP_10"},{"id":"T119","span":{"begin":640,"end":645},"obj":"NCBITaxon:10239"},{"id":"T120","span":{"begin":653,"end":656},"obj":"UBERON:0001017"},{"id":"T121","span":{"begin":758,"end":766},"obj":"SP_7"},{"id":"T122","span":{"begin":937,"end":945},"obj":"SP_7"},{"id":"T123","span":{"begin":1131,"end":1139},"obj":"SP_7"},{"id":"T124","span":{"begin":1334,"end":1342},"obj":"SP_7"},{"id":"T125","span":{"begin":1486,"end":1494},"obj":"SP_7"},{"id":"T126","span":{"begin":1548,"end":1556},"obj":"SP_7"},{"id":"T82743","span":{"begin":28,"end":36},"obj":"SP_7"},{"id":"T36602","span":{"begin":47,"end":59},"obj":"UBERON:0001016"},{"id":"T51429","span":{"begin":221,"end":229},"obj":"SP_7"},{"id":"T16606","span":{"begin":324,"end":327},"obj":"UBERON:0001017"},{"id":"T62395","span":{"begin":328,"end":338},"obj":"SP_7"},{"id":"T11895","span":{"begin":339,"end":344},"obj":"NCBITaxon:10239"},{"id":"T62294","span":{"begin":407,"end":417},"obj":"SP_7"},{"id":"T71986","span":{"begin":418,"end":423},"obj":"NCBITaxon:10239"},{"id":"T36275","span":{"begin":424,"end":427},"obj":"UBERON:0001017"},{"id":"T91754","span":{"begin":477,"end":489},"obj":"UBERON:0001016"},{"id":"T27394","span":{"begin":528,"end":540},"obj":"UBERON:0001016"},{"id":"T42455","span":{"begin":569,"end":577},"obj":"SP_7"},{"id":"T26760","span":{"begin":628,"end":636},"obj":"SP_10"},{"id":"T80912","span":{"begin":640,"end":645},"obj":"NCBITaxon:10239"},{"id":"T84291","span":{"begin":653,"end":656},"obj":"UBERON:0001017"},{"id":"T26444","span":{"begin":758,"end":766},"obj":"SP_7"},{"id":"T3748","span":{"begin":937,"end":945},"obj":"SP_7"},{"id":"T20171","span":{"begin":1131,"end":1139},"obj":"SP_7"},{"id":"T61567","span":{"begin":1334,"end":1342},"obj":"SP_7"},{"id":"T73298","span":{"begin":1486,"end":1494},"obj":"SP_7"},{"id":"T56196","span":{"begin":1548,"end":1556},"obj":"SP_7"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"MyTest","denotations":[{"id":"32833573-32416028-28640892","span":{"begin":498,"end":501},"obj":"32416028"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}

{"project":"testtesttest","denotations":[{"id":"T17","span":{"begin":324,"end":327},"obj":"Body_part"},{"id":"T18","span":{"begin":424,"end":427},"obj":"Body_part"},{"id":"T19","span":{"begin":653,"end":656},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"Summary\nMultiple reports on COVID-19 show that neurological complications are most associated with severe cases. Individual case reports provide helpful details of acute symptomatic seizures during the clinical course of COVID-19 infection, but overall leave open the question as to whether systemic complications or direct CNS SARS-CoV-2 virus infections cause seizures. While a neuroinvasive mechanism of SARS-CoV-2 virus CNS infection remains a postulated cause of clinical neurological disease,16 investigation of new-onset neurological impairments associated with COVID-19 found lack of evidence for direct acute insult of SARS-CoV-19 virus to the CNS.28\nThere is no conclusive evidence from cohort studies that seizures due to epilepsy are worsened in COVID-19 patients, but there are few cohort studies focusing on patients with a history of seizures and epilepsy. Among the multiple systemic and environmental factors related to COVID-19 infection causing seizures, the underlying susceptibility for seizures due to epilepsy is likely the most significant factor.1 Therefore, there is a need for further studies evaluating COVID-19 in epilepsy patients. However, clinical experience with seizures and epilepsy in general indicates that exacerbation of seizures, especially from systemic effects such as those caused by severe COVID-19, will be a major concern. Given this likelihood, health care providers should take extra care to assist their patients in preventing potential COVID-19 infection and closely monitor epilepsy patients with COVID-19 for worsening of their seizures."}