PMC:7443692 / 4025-4383 JSONTXT

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T4","span":{"begin":28,"end":40},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A4","pred":"meddra_id","subj":"T4","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"}],"text":"impaired ACE2 has also been investigated as a potential therapeutic biologic that might interfere with the infection cycle of ACE2-targeting coronaviruses (Lei et al., 2020; Monteil et al., 2020). Thus, a detailed understanding of SARS-CoV-2 Spike binding to ACE2 is critical for elucidating mechanisms of viral binding and entry, as well as for undertaking "}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T25","span":{"begin":231,"end":241},"obj":"Species"}],"attributes":[{"id":"A25","pred":"ncbi_taxonomy_id","subj":"T25","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"impaired ACE2 has also been investigated as a potential therapeutic biologic that might interfere with the infection cycle of ACE2-targeting coronaviruses (Lei et al., 2020; Monteil et al., 2020). Thus, a detailed understanding of SARS-CoV-2 Spike binding to ACE2 is critical for elucidating mechanisms of viral binding and entry, as well as for undertaking "}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T17","span":{"begin":107,"end":116},"obj":"Disease"},{"id":"T18","span":{"begin":231,"end":241},"obj":"Disease"}],"attributes":[{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"impaired ACE2 has also been investigated as a potential therapeutic biologic that might interfere with the infection cycle of ACE2-targeting coronaviruses (Lei et al., 2020; Monteil et al., 2020). Thus, a detailed understanding of SARS-CoV-2 Spike binding to ACE2 is critical for elucidating mechanisms of viral binding and entry, as well as for undertaking "}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T403","span":{"begin":9,"end":13},"obj":"Protein"},{"id":"T404","span":{"begin":126,"end":130},"obj":"Protein"},{"id":"T405","span":{"begin":259,"end":263},"obj":"Protein"}],"attributes":[{"id":"A403","pred":"uniprot_id","subj":"T403","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A404","pred":"uniprot_id","subj":"T404","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A405","pred":"uniprot_id","subj":"T405","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"impaired ACE2 has also been investigated as a potential therapeutic biologic that might interfere with the infection cycle of ACE2-targeting coronaviruses (Lei et al., 2020; Monteil et al., 2020). Thus, a detailed understanding of SARS-CoV-2 Spike binding to ACE2 is critical for elucidating mechanisms of viral binding and entry, as well as for undertaking "}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T26","span":{"begin":107,"end":116},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"}],"text":"impaired ACE2 has also been investigated as a potential therapeutic biologic that might interfere with the infection cycle of ACE2-targeting coronaviruses (Lei et al., 2020; Monteil et al., 2020). Thus, a detailed understanding of SARS-CoV-2 Spike binding to ACE2 is critical for elucidating mechanisms of viral binding and entry, as well as for undertaking "}

{"project":"2_test","denotations":[{"id":"32841605-32332765-19659471","span":{"begin":168,"end":172},"obj":"32332765"},{"id":"32841605-32333836-19659472","span":{"begin":190,"end":194},"obj":"32333836"}],"text":"impaired ACE2 has also been investigated as a potential therapeutic biologic that might interfere with the infection cycle of ACE2-targeting coronaviruses (Lei et al., 2020; Monteil et al., 2020). Thus, a detailed understanding of SARS-CoV-2 Spike binding to ACE2 is critical for elucidating mechanisms of viral binding and entry, as well as for undertaking "}