PMC:7443692 / 1063-1599 JSONTXT

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T8","span":{"begin":478,"end":485},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T6","span":{"begin":253,"end":263},"obj":"Species"},{"id":"T7","span":{"begin":317,"end":322},"obj":"Species"}],"attributes":[{"id":"A6","pred":"ncbi_taxonomy_id","subj":"T6","obj":"NCBItxid:2697049"},{"id":"A7","pred":"ncbi_taxonomy_id","subj":"T7","obj":"NCBItxid:9606"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T9","span":{"begin":151,"end":169},"obj":"Sentence"},{"id":"T10","span":{"begin":171,"end":181},"obj":"Sentence"},{"id":"T11","span":{"begin":182,"end":269},"obj":"Sentence"},{"id":"T12","span":{"begin":270,"end":350},"obj":"Sentence"},{"id":"T13","span":{"begin":351,"end":441},"obj":"Sentence"},{"id":"T14","span":{"begin":442,"end":523},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T3","span":{"begin":133,"end":148},"obj":"Disease"},{"id":"T4","span":{"begin":253,"end":263},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T277","span":{"begin":323,"end":327},"obj":"Protein"},{"id":"T278","span":{"begin":398,"end":402},"obj":"Protein"}],"attributes":[{"id":"A277","pred":"uniprot_id","subj":"T277","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A278","pred":"uniprot_id","subj":"T278","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T6","span":{"begin":139,"end":148},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T7","span":{"begin":185,"end":189},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T8","span":{"begin":244,"end":249},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T9","span":{"begin":277,"end":282},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T8","span":{"begin":64,"end":72},"obj":"Body_part"},{"id":"T9","span":{"begin":478,"end":485},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T4","span":{"begin":133,"end":148},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T5","span":{"begin":428,"end":441},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T4","span":{"begin":133,"end":148},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T5","span":{"begin":428,"end":441},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T23","span":{"begin":36,"end":45},"obj":"CHEBI:60816;CHEBI:60816"},{"id":"T24","span":{"begin":64,"end":72},"obj":"GO:0042571"},{"id":"T25","span":{"begin":133,"end":138},"obj":"NCBITaxon:10239"},{"id":"T26","span":{"begin":253,"end":263},"obj":"SP_7"},{"id":"T27","span":{"begin":317,"end":322},"obj":"SP_6;NCBITaxon:9606;PG_10"},{"id":"T28","span":{"begin":323,"end":327},"obj":"PG_10;PR:000003622"},{"id":"T29","span":{"begin":398,"end":402},"obj":"G_3;PG_10;PR:000003622"},{"id":"T30","span":{"begin":486,"end":492},"obj":"CHEBI:17089;CHEBI:17089"},{"id":"T31","span":{"begin":497,"end":503},"obj":"CHEBI:17089;CHEBI:17089"},{"id":"T32","span":{"begin":504,"end":510},"obj":"CHEBI:17089;CHEBI:17089"}],"text":"together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions\n\nCombining g"}