PMC:7441788 / 5260-5969 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T15","span":{"begin":100,"end":104},"obj":"Body_part"},{"id":"T16","span":{"begin":416,"end":420},"obj":"Body_part"},{"id":"T17","span":{"begin":533,"end":538},"obj":"Body_part"},{"id":"T18","span":{"begin":589,"end":600},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma62100"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma62100"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma7647"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":100,"end":104},"obj":"Body_part"},{"id":"T2","span":{"begin":416,"end":420},"obj":"Body_part"},{"id":"T3","span":{"begin":533,"end":538},"obj":"Body_part"},{"id":"T4","span":{"begin":589,"end":600},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002240"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T50","span":{"begin":557,"end":566},"obj":"Disease"}],"attributes":[{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T50","span":{"begin":58,"end":66},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T51","span":{"begin":120,"end":125},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T52","span":{"begin":257,"end":258},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T53","span":{"begin":468,"end":473},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T54","span":{"begin":533,"end":538},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T55","span":{"begin":533,"end":538},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T56","span":{"begin":589,"end":600},"obj":"http://purl.obolibrary.org/obo/UBERON_0002240"},{"id":"T57","span":{"begin":652,"end":653},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":679,"end":687},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T65","span":{"begin":28,"end":30},"obj":"Chemical"},{"id":"T66","span":{"begin":221,"end":223},"obj":"Chemical"},{"id":"T67","span":{"begin":346,"end":348},"obj":"Chemical"},{"id":"T68","span":{"begin":448,"end":450},"obj":"Chemical"},{"id":"T69","span":{"begin":481,"end":483},"obj":"Chemical"},{"id":"T70","span":{"begin":640,"end":642},"obj":"Chemical"}],"attributes":[{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A67","pred":"chebi_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A68","pred":"chebi_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T42","span":{"begin":28,"end":30},"obj":"Chemical"},{"id":"T43","span":{"begin":221,"end":223},"obj":"Chemical"},{"id":"T44","span":{"begin":346,"end":348},"obj":"Chemical"},{"id":"T45","span":{"begin":448,"end":450},"obj":"Chemical"},{"id":"T46","span":{"begin":481,"end":483},"obj":"Chemical"},{"id":"T47","span":{"begin":640,"end":642},"obj":"Chemical"}],"attributes":[{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T48","span":{"begin":48,"end":57},"obj":"Species"},{"id":"T49","span":{"begin":120,"end":125},"obj":"Species"},{"id":"T51","span":{"begin":186,"end":190},"obj":"Species"},{"id":"T53","span":{"begin":398,"end":402},"obj":"Species"},{"id":"T55","span":{"begin":468,"end":473},"obj":"Species"},{"id":"T57","span":{"begin":504,"end":513},"obj":"Species"}],"attributes":[{"id":"A57","pred":"ncbi_taxonomy_id","subj":"T57","obj":"NCBItxid:31631"},{"id":"A55","pred":"ncbi_taxonomy_id","subj":"T55","obj":"NCBItxid:10090"},{"id":"A56","pred":"ncbi_taxonomy_id","subj":"T55","obj":"NCBItxid:10088"},{"id":"A51","pred":"ncbi_taxonomy_id","subj":"T51","obj":"NCBItxid:10095"},{"id":"A52","pred":"ncbi_taxonomy_id","subj":"T51","obj":"NCBItxid:10088"},{"id":"A48","pred":"ncbi_taxonomy_id","subj":"T48","obj":"NCBItxid:31631"},{"id":"A53","pred":"ncbi_taxonomy_id","subj":"T53","obj":"NCBItxid:10095"},{"id":"A54","pred":"ncbi_taxonomy_id","subj":"T53","obj":"NCBItxid:10088"},{"id":"A49","pred":"ncbi_taxonomy_id","subj":"T49","obj":"NCBItxid:10090"},{"id":"A50","pred":"ncbi_taxonomy_id","subj":"T49","obj":"NCBItxid:10088"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T43","span":{"begin":106,"end":368},"obj":"Sentence"},{"id":"T44","span":{"begin":369,"end":456},"obj":"Sentence"},{"id":"T45","span":{"begin":457,"end":606},"obj":"Sentence"},{"id":"T46","span":{"begin":607,"end":709},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T1","span":{"begin":100,"end":104},"obj":"Body_part"},{"id":"T2","span":{"begin":416,"end":420},"obj":"Body_part"},{"id":"T3","span":{"begin":533,"end":538},"obj":"Body_part"},{"id":"T4","span":{"begin":589,"end":600},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002240"},{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"228","span":{"begin":120,"end":125},"obj":"Species"},{"id":"229","span":{"begin":186,"end":190},"obj":"Species"},{"id":"230","span":{"begin":398,"end":402},"obj":"Species"},{"id":"231","span":{"begin":468,"end":473},"obj":"Species"},{"id":"232","span":{"begin":504,"end":513},"obj":"Species"},{"id":"233","span":{"begin":48,"end":57},"obj":"Species"},{"id":"234","span":{"begin":28,"end":30},"obj":"Chemical"},{"id":"235","span":{"begin":221,"end":223},"obj":"Chemical"},{"id":"236","span":{"begin":346,"end":348},"obj":"Chemical"},{"id":"237","span":{"begin":448,"end":450},"obj":"Chemical"},{"id":"238","span":{"begin":481,"end":483},"obj":"Chemical"},{"id":"239","span":{"begin":557,"end":566},"obj":"Disease"}],"attributes":[{"id":"A235","pred":"pubann:denotes","subj":"235","obj":"MESH:D002738"},{"id":"A228","pred":"pubann:denotes","subj":"228","obj":"Tax:10090"},{"id":"A230","pred":"pubann:denotes","subj":"230","obj":"Tax:10090"},{"id":"A233","pred":"pubann:denotes","subj":"233","obj":"Tax:31631"},{"id":"A239","pred":"pubann:denotes","subj":"239","obj":"MESH:D007239"},{"id":"A236","pred":"pubann:denotes","subj":"236","obj":"MESH:D002738"},{"id":"A238","pred":"pubann:denotes","subj":"238","obj":"MESH:D002738"},{"id":"A232","pred":"pubann:denotes","subj":"232","obj":"Tax:31631"},{"id":"A237","pred":"pubann:denotes","subj":"237","obj":"MESH:D002738"},{"id":"A231","pred":"pubann:denotes","subj":"231","obj":"Tax:10090"},{"id":"A234","pred":"pubann:denotes","subj":"234","obj":"MESH:D002738"},{"id":"A229","pred":"pubann:denotes","subj":"229","obj":"Tax:10090"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T42","span":{"begin":514,"end":525},"obj":"http://purl.obolibrary.org/obo/IDO_0000608"},{"id":"T43","span":{"begin":557,"end":566},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T15","span":{"begin":100,"end":104},"obj":"Body_part"},{"id":"T16","span":{"begin":416,"end":420},"obj":"Body_part"},{"id":"T17","span":{"begin":533,"end":538},"obj":"Body_part"},{"id":"T18","span":{"begin":589,"end":600},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma7647"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma62100"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma62100"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T1","span":{"begin":533,"end":538},"obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"T2","span":{"begin":589,"end":600},"obj":"http://purl.obolibrary.org/obo/MAT_0000183"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T43","span":{"begin":557,"end":566},"obj":"Disease"}],"attributes":[{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-PubTator","denotations":[{"id":"228","span":{"begin":120,"end":125},"obj":"Species"},{"id":"229","span":{"begin":186,"end":190},"obj":"Species"},{"id":"230","span":{"begin":398,"end":402},"obj":"Species"},{"id":"231","span":{"begin":468,"end":473},"obj":"Species"},{"id":"232","span":{"begin":504,"end":513},"obj":"Species"},{"id":"233","span":{"begin":48,"end":57},"obj":"Species"},{"id":"234","span":{"begin":28,"end":30},"obj":"Chemical"},{"id":"235","span":{"begin":221,"end":223},"obj":"Chemical"},{"id":"236","span":{"begin":346,"end":348},"obj":"Chemical"},{"id":"237","span":{"begin":448,"end":450},"obj":"Chemical"},{"id":"238","span":{"begin":481,"end":483},"obj":"Chemical"},{"id":"239","span":{"begin":557,"end":566},"obj":"Disease"}],"attributes":[{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Tax:10090"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Tax:10090"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Tax:10090"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"Tax:10090"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Tax:31631"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"Tax:31631"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:D002738"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D002738"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"MESH:D002738"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:D002738"},{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"MESH:D002738"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"LitCovid-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T43","span":{"begin":106,"end":368},"obj":"Sentence"},{"id":"T44","span":{"begin":369,"end":456},"obj":"Sentence"},{"id":"T45","span":{"begin":457,"end":606},"obj":"Sentence"},{"id":"T46","span":{"begin":607,"end":709},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}

{"project":"2_test","denotations":[{"id":"32496926-19506054-132195662","span":{"begin":364,"end":366},"obj":"19506054"},{"id":"32496926-19506054-132195663","span":{"begin":452,"end":454},"obj":"19506054"}],"text":"An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo."}