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PMC:7441788 / 35315-39123 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T118 509-512 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T119 514-535 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T120 541-546 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T121 1053-1075 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T122 1095-1100 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T123 1105-1111 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T124 1166-1171 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T125 1176-1182 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T126 3150-3155 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T127 3508-3515 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 509-512 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T16 514-535 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T17 541-546 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T18 1095-1100 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T19 1105-1111 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T20 1166-1171 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T21 1176-1182 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T22 3150-3155 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T137 44-51 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T138 333-341 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T139 576-584 Disease denotes deafness http://purl.obolibrary.org/obo/MONDO_0005365
T140 586-605 Disease denotes conduction disorder http://purl.obolibrary.org/obo/MONDO_0007264
T141 606-620 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T142 626-636 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T143 959-970 Disease denotes retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T144 1358-1366 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 1648-1683 Disease denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000466
T146 1661-1683 Disease denotes atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000465
T147 1907-1915 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T148 2011-2020 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T149 2037-2045 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 2204-2212 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T151 2747-2757 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T152 2774-2782 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T153 3150-3163 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T154 3543-3547 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T155 3597-3613 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T156 3607-3613 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T157 3678-3693 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T158 3771-3786 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T247 57-58 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 509-512 http://www.ebi.ac.uk/efo/EFO_0000826 denotes ear
T249 514-535 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
T250 514-535 http://www.ebi.ac.uk/efo/EFO_0000791 denotes cardiovascular system
T251 541-546 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T252 541-546 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T253 706-709 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T254 780-786 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T255 1053-1075 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T256 1095-1100 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T257 1095-1100 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T258 1105-1111 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T259 1105-1111 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T260 1105-1111 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T261 1117-1118 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 1166-1171 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T263 1166-1171 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T264 1176-1182 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T265 1176-1182 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T266 1176-1182 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T267 1578-1579 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 1616-1618 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T269 1646-1647 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 1707-1708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 1931-1932 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T272 2367-2369 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T273 2389-2390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 2443-2445 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T275 2504-2506 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T276 2580-2582 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T277 2623-2624 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 2653-2654 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 2900-2901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 3150-3155 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T281 3150-3155 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T282 3150-3155 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T283 3150-3155 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T284 3470-3479 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T373 11-13 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T374 142-144 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T375 270-272 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T376 462-464 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T377 698-700 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T378 829-831 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T379 977-979 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T380 1236-1238 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T381 1518-1521 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T382 2113-2125 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T383 2323-2335 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T384 2482-2494 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T385 2611-2613 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T386 2615-2617 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T387 2625-2634 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T388 2655-2664 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T389 2877-2879 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T390 2902-2911 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T391 2918-2920 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T392 3013-3021 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T393 3086-3088 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T394 3203-3208 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T395 3233-3238 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T396 3240-3254 Chemical denotes antihistamines http://purl.obolibrary.org/obo/CHEBI_37956
T397 3260-3272 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T398 3361-3366 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T399 3375-3380 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T400 3464-3466 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T401 3508-3515 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T403 3518-3527 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T407 3699-3701 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T408 3805-3807 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T20 2935-2952 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes electrocardiogram http://purl.bioontology.org/ontology/MEDDRA/10014362
T21 3508-3541 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes glucose 6-phosphate dehydrogenase http://purl.bioontology.org/ontology/MEDDRA/10059900

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T210 11-13 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T211 142-144 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T212 270-272 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T213 462-464 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T214 698-700 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T215 829-831 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T216 977-979 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T217 1236-1238 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T218 1518-1521 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T219 2113-2125 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T220 2323-2335 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T221 2482-2494 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T222 2611-2613 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T223 2615-2617 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T224 2625-2634 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T225 2655-2664 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T226 2877-2879 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T227 2902-2911 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T228 2918-2920 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T229 3086-3088 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T230 3260-3272 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T231 3464-3466 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T232 3508-3515 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T234 3518-3527 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T238 3699-3701 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T239 3805-3807 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T133 1358-1366 Species denotes COVID-19 NCBItxid:2697049
T134 1907-1915 Species denotes COVID-19 NCBItxid:2697049
T135 2037-2045 Species denotes COVID-19 NCBItxid:2697049
T136 2204-2212 Species denotes COVID-19 NCBItxid:2697049
T137 2774-2782 Species denotes COVID-19 NCBItxid:2697049
T138 3607-3613 Species denotes anemia NCBItxid:12939

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T239 0-2 Sentence denotes 6.
T240 4-10 Sentence denotes Safety
T241 11-106 Sentence denotes CQ/HCQ are basic medications for malaria with a long history of reliable safety records [3,62].
T242 107-227 Sentence denotes However, the therapeutic window of CQ is narrow, and the toxic dose is 3 times higher than the therapeutic dose [55,63].
T243 228-356 Sentence denotes The most common adverse effects of taking CQ are gastrointestinal discomforts, such as nausea, vomiting, diarrhea, and anorexia.
T244 357-428 Sentence denotes These symptoms are mild and can be controlled by reducing the dose [3].
T245 429-685 Sentence denotes However, long-term and high-dose CQ intake can cause irreversible damage to the ear, cardiovascular system, and blood system, such as neurological deafness, conduction disorder cardiomyopathy, and leukopenia, though these adverse effects are very rare [3].
T246 686-776 Sentence denotes Compared to CQ, HCQ has fewer adverse effects, which may be related to its lower toxicity.
T247 777-837 Sentence denotes In animal models, HCQ was about 40% less toxic than CQ [64].
T248 838-976 Sentence denotes Reportedly, only overdoses (average daily dose > 5.0 mg/kg) and long-time (more than 5 years) ingestion of HCQ can cause retinopathy [65].
T249 977-1154 Sentence denotes CQ/HCQ have similar pharmacokinetic characteristics, fast absorption in the gastrointestinal tract, fast excretion in liver and kidney, and a long half-life (40–50 days) [3,66].
T250 1155-1225 Sentence denotes Therefore, liver and kidney dysfunction may aggravate adverse effects.
T251 1226-1402 Sentence denotes High-dose CQ (600 mg/2 times/day for 10 day) is associated with increased QTc interval prolongation in critically ill patients with COVID-19 [49] and should not be recommended.
T252 1403-1550 Sentence denotes In the initial trial from France, of the 84 patients receiving HCQ treatment, 8 patients discontinued HCQ owing to ECG modifications within 4 days.
T253 1551-1703 Sentence denotes Among them, 7 patients had a prolonged QTc interval more than 60 ms, and one patient developed a first-degree atrioventricular block within 2 days [53].
T254 1704-1843 Sentence denotes In a randomized clinical trial from Wuhan, 2 out of 31 patients receiving HCQ treatment had minor adverse effects (headache and rash) [50].
T255 1844-1930 Sentence denotes Prolonged QT interval after taking HCQ may also develop in ICU COVID-19 patients [67].
T256 1931-2180 Sentence denotes A recent observation showed that patients who received HCQ for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation (19%), and concurrent use of azithromycin was associated with greater changes in QTc (21%) [68].
T257 2181-2599 Sentence denotes Another observation in COVID-19 patients admitted to ICU showed that QTc intervals increased in 93% of patients receiving HCQ with or without azithromycin, prolonged QTc was observed in 36% of patients after a duration of the treatment for 2 to 5 days, and 6 of 18 (33%) patients treated with HCQ and azithromycin and 1 of 22 (5%) of those treated with HCQ alone developed an increase in QTc of 500 ms or greater [69].
T258 2600-2797 Sentence denotes The use of CQ, CQ with a macrolide, HCQ and HCQ with a macrolide were all found to be independently associated with increased risk for ventricular arrhythmia in hospitalized COVID-19 patients [61].
T259 2798-2912 Sentence denotes Therefore, clinicians should carefully weigh risks and benefits if considering CQ/HCQ with or without a macrolide.
T260 2913-3085 Sentence denotes When CQ/HCQ are used, electrocardiogram examination should be routinely performed before taking the medicine, with close monitoring of QTc and concomitant medication usage.
T261 3086-3291 Sentence denotes CQ/HCQ should be more cautiously used in patients with existing heart disease, and the use of QT interval prolonging drugs, such as antiarrhythmic drugs, antihistamines, and moxifloxacin should be avoided.
T262 3292-3450 Sentence denotes In addition, close attention should be paid to symptoms after taking drugs and the drugs should be stopped in time if there are intolerable adverse reactions.
T263 3451-3619 Sentence denotes In addition, CQ is extremely dangerous for patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency because of the possible induction of hemolytic anemia [70].
T264 3620-3808 Sentence denotes Therefore, more caution should be given for patients with G6PD deficiency when CQ is considered for the treatment and the best way should be to detect G6PD deficiency before the use of CQ.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T13 509-512 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T14 514-535 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T15 541-546 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T16 1095-1100 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T17 1105-1111 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T18 1166-1171 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T19 1176-1182 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T20 3150-3155 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1339 1344-1352 Species denotes patients Tax:9606
1340 1447-1455 Species denotes patients Tax:9606
1341 1483-1491 Species denotes patients Tax:9606
1342 1565-1573 Species denotes patients Tax:9606
1343 1628-1635 Species denotes patient Tax:9606
1344 1759-1767 Species denotes patients Tax:9606
1345 1916-1924 Species denotes patients Tax:9606
1346 1964-1972 Species denotes patients Tax:9606
1347 2213-2221 Species denotes patients Tax:9606
1348 2284-2292 Species denotes patients Tax:9606
1349 2374-2382 Species denotes patients Tax:9606
1350 2452-2460 Species denotes patients Tax:9606
1351 2783-2791 Species denotes patients Tax:9606
1352 3127-3135 Species denotes patients Tax:9606
1353 3494-3502 Species denotes patients Tax:9606
1354 3664-3672 Species denotes patients Tax:9606
1355 11-17 Chemical denotes CQ/HCQ
1356 142-144 Chemical denotes CQ MESH:D002738
1357 270-272 Chemical denotes CQ MESH:D002738
1358 462-464 Chemical denotes CQ MESH:D002738
1359 698-700 Chemical denotes CQ MESH:D002738
1360 702-705 Chemical denotes HCQ MESH:D006886
1361 795-798 Chemical denotes HCQ MESH:D006886
1362 829-831 Chemical denotes CQ MESH:D002738
1363 945-948 Chemical denotes HCQ MESH:D006886
1364 977-979 Chemical denotes CQ MESH:D002738
1365 980-983 Chemical denotes HCQ MESH:D006886
1366 1236-1238 Chemical denotes CQ MESH:D002738
1367 1466-1469 Chemical denotes HCQ MESH:D006886
1368 1505-1508 Chemical denotes HCQ MESH:D006886
1369 1778-1781 Chemical denotes HCQ MESH:D006886
1370 1879-1882 Chemical denotes HCQ MESH:D006886
1371 1986-1989 Chemical denotes HCQ MESH:D006886
1372 2113-2125 Chemical denotes azithromycin MESH:D017963
1373 2303-2306 Chemical denotes HCQ MESH:D006886
1374 2323-2335 Chemical denotes azithromycin MESH:D017963
1375 2474-2477 Chemical denotes HCQ MESH:D006886
1376 2482-2494 Chemical denotes azithromycin MESH:D017963
1377 2534-2537 Chemical denotes HCQ MESH:D006886
1378 2611-2613 Chemical denotes CQ MESH:D002738
1379 2615-2617 Chemical denotes CQ MESH:D002738
1380 2625-2634 Chemical denotes macrolide MESH:D018942
1381 2636-2639 Chemical denotes HCQ MESH:D006886
1382 2644-2647 Chemical denotes HCQ MESH:D006886
1383 2655-2664 Chemical denotes macrolide MESH:D018942
1384 2877-2883 Chemical denotes CQ/HCQ
1385 2902-2911 Chemical denotes macrolide MESH:D018942
1386 2918-2924 Chemical denotes CQ/HCQ
1387 3086-3092 Chemical denotes CQ/HCQ
1388 3260-3272 Chemical denotes moxifloxacin MESH:D000077266
1389 3464-3466 Chemical denotes CQ MESH:D002738
1390 3699-3701 Chemical denotes CQ MESH:D002738
1391 3805-3807 Chemical denotes CQ MESH:D002738
1392 44-51 Disease denotes malaria MESH:D008288
1393 315-321 Disease denotes nausea MESH:D009325
1394 323-331 Disease denotes vomiting MESH:D014839
1395 333-341 Disease denotes diarrhea MESH:D003967
1396 347-355 Disease denotes anorexia MESH:D000855
1397 514-535 Disease denotes cardiovascular system MESH:D002318
1398 563-584 Disease denotes neurological deafness MESH:D009422
1399 586-620 Disease denotes conduction disorder cardiomyopathy MESH:C563384
1400 626-636 Disease denotes leukopenia MESH:D007970
1401 767-775 Disease denotes toxicity MESH:D064420
1402 959-970 Disease denotes retinopathy MESH:D012164
1403 1166-1194 Disease denotes liver and kidney dysfunction MESH:D051437
1404 1290-1325 Disease denotes increased QTc interval prolongation MESH:D008133
1405 1329-1343 Disease denotes critically ill MESH:D016638
1406 1358-1366 Disease denotes COVID-19 MESH:C000657245
1407 1661-1683 Disease denotes atrioventricular block MESH:D054537
1408 1819-1827 Disease denotes headache MESH:D006261
1409 1832-1836 Disease denotes rash MESH:D005076
1410 1907-1915 Disease denotes COVID-19 MESH:C000657245
1411 2011-2020 Disease denotes pneumonia MESH:D011014
1412 2037-2045 Disease denotes COVID-19 MESH:C000657245
1413 2067-2083 Disease denotes QTc prolongation MESH:D008133
1414 2204-2212 Disease denotes COVID-19 MESH:C000657245
1415 2735-2757 Disease denotes ventricular arrhythmia MESH:D001145
1416 2774-2782 Disease denotes COVID-19 MESH:C000657245
1417 3150-3163 Disease denotes heart disease MESH:D006331
1418 3508-3559 Disease denotes glucose 6-phosphate dehydrogenase (G6PD) deficiency MESH:D005955
1419 3597-3613 Disease denotes hemolytic anemia MESH:D000743
1420 3678-3693 Disease denotes G6PD deficiency MESH:D005955
1421 3771-3786 Disease denotes G6PD deficiency MESH:D005955

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1302 3508-3541 Protein denotes glucose 6-phosphate dehydrogenase https://www.uniprot.org/uniprot/R4GMU1|https://www.uniprot.org/uniprot/Q8CFX1|https://www.uniprot.org/uniprot/Q8BLH1|https://www.uniprot.org/uniprot/Q68DT3|https://www.uniprot.org/uniprot/Q66I35|https://www.uniprot.org/uniprot/Q4TT33|https://www.uniprot.org/uniprot/P56201|https://www.uniprot.org/uniprot/O95479|https://www.uniprot.org/uniprot/G1SE36|https://www.uniprot.org/uniprot/B2KGW7|https://www.uniprot.org/uniprot/A2A7A9
T1313 3543-3547 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1
T1345 3678-3682 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1
T1377 3771-3775 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T141 64-71 http://purl.obolibrary.org/obo/BFO_0000182 denotes history
T142 363-371 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T143 541-546 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T144 597-605 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorder
T145 3156-3163 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T146 3339-3347 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T117 509-512 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T118 514-535 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T119 541-546 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T120 1053-1075 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T121 1095-1100 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T122 1105-1111 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T123 1166-1171 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T124 1176-1182 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T125 3150-3155 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T126 3508-3515 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T9 509-512 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T10 509-512 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T11 509-512 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T12 514-535 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T13 541-546 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T14 541-546 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T15 1095-1100 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T16 1105-1111 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T17 1166-1171 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T18 1176-1182 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T19 3150-3155 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T76 1082-1091 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T130 44-51 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T131 333-341 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T132 576-584 Disease denotes deafness http://purl.obolibrary.org/obo/MONDO_0005365
T133 586-605 Disease denotes conduction disorder http://purl.obolibrary.org/obo/MONDO_0007264
T134 606-620 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T135 626-636 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T136 959-970 Disease denotes retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T137 1358-1366 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T138 1648-1683 Disease denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000466
T139 1832-1836 Disease denotes rash http://purl.obolibrary.org/obo/MONDO_0006547
T140 1907-1915 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T141 2011-2020 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T142 2037-2045 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T143 2204-2212 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T144 2747-2757 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T145 2774-2782 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T146 3150-3163 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T147 3543-3547 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T148 3597-3613 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T149 3678-3693 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T150 3771-3786 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T24 315-331 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T25 333-341 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T26 347-355 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T27 576-584 Phenotype denotes deafness http://purl.obolibrary.org/obo/HP_0000365
T28 606-620 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T29 626-636 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T30 959-970 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T31 1580-1602 Phenotype denotes prolonged QTc interval http://purl.obolibrary.org/obo/HP_0005184
T32 1648-1683 Phenotype denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/HP_0011705
T33 1819-1827 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T34 1832-1836 Phenotype denotes rash http://purl.obolibrary.org/obo/HP_0000988
T35 1844-1865 Phenotype denotes Prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T36 2011-2020 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T37 2735-2757 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T38 3597-3613 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T67 1082-1091 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T63 1082-1091 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1339 1344-1352 Species denotes patients Tax:9606
1340 1447-1455 Species denotes patients Tax:9606
1341 1483-1491 Species denotes patients Tax:9606
1342 1565-1573 Species denotes patients Tax:9606
1343 1628-1635 Species denotes patient Tax:9606
1344 1759-1767 Species denotes patients Tax:9606
1345 1916-1924 Species denotes patients Tax:9606
1346 1964-1972 Species denotes patients Tax:9606
1347 2213-2221 Species denotes patients Tax:9606
1348 2284-2292 Species denotes patients Tax:9606
1349 2374-2382 Species denotes patients Tax:9606
1350 2452-2460 Species denotes patients Tax:9606
1351 2783-2791 Species denotes patients Tax:9606
1352 3127-3135 Species denotes patients Tax:9606
1353 3494-3502 Species denotes patients Tax:9606
1354 3664-3672 Species denotes patients Tax:9606
1355 11-17 Chemical denotes CQ/HCQ
1356 142-144 Chemical denotes CQ MESH:D002738
1357 270-272 Chemical denotes CQ MESH:D002738
1358 462-464 Chemical denotes CQ MESH:D002738
1359 698-700 Chemical denotes CQ MESH:D002738
1360 702-705 Chemical denotes HCQ MESH:D006886
1361 795-798 Chemical denotes HCQ MESH:D006886
1362 829-831 Chemical denotes CQ MESH:D002738
1363 945-948 Chemical denotes HCQ MESH:D006886
1364 977-979 Chemical denotes CQ MESH:D002738
1365 980-983 Chemical denotes HCQ MESH:D006886
1366 1236-1238 Chemical denotes CQ MESH:D002738
1367 1466-1469 Chemical denotes HCQ MESH:D006886
1368 1505-1508 Chemical denotes HCQ MESH:D006886
1369 1778-1781 Chemical denotes HCQ MESH:D006886
1370 1879-1882 Chemical denotes HCQ MESH:D006886
1371 1986-1989 Chemical denotes HCQ MESH:D006886
1372 2113-2125 Chemical denotes azithromycin MESH:D017963
1373 2303-2306 Chemical denotes HCQ MESH:D006886
1374 2323-2335 Chemical denotes azithromycin MESH:D017963
1375 2474-2477 Chemical denotes HCQ MESH:D006886
1376 2482-2494 Chemical denotes azithromycin MESH:D017963
1377 2534-2537 Chemical denotes HCQ MESH:D006886
1378 2611-2613 Chemical denotes CQ MESH:D002738
1379 2615-2617 Chemical denotes CQ MESH:D002738
1380 2625-2634 Chemical denotes macrolide MESH:D018942
1381 2636-2639 Chemical denotes HCQ MESH:D006886
1382 2644-2647 Chemical denotes HCQ MESH:D006886
1383 2655-2664 Chemical denotes macrolide MESH:D018942
1384 2877-2883 Chemical denotes CQ/HCQ
1385 2902-2911 Chemical denotes macrolide MESH:D018942
1386 2918-2924 Chemical denotes CQ/HCQ
1387 3086-3092 Chemical denotes CQ/HCQ
1388 3260-3272 Chemical denotes moxifloxacin MESH:D000077266
1389 3464-3466 Chemical denotes CQ MESH:D002738
1390 3699-3701 Chemical denotes CQ MESH:D002738
1391 3805-3807 Chemical denotes CQ MESH:D002738
1392 44-51 Disease denotes malaria MESH:D008288
1393 315-321 Disease denotes nausea MESH:D009325
1394 323-331 Disease denotes vomiting MESH:D014839
1395 333-341 Disease denotes diarrhea MESH:D003967
1396 347-355 Disease denotes anorexia MESH:D000855
1397 514-535 Disease denotes cardiovascular system MESH:D002318
1398 563-584 Disease denotes neurological deafness MESH:D009422
1399 586-620 Disease denotes conduction disorder cardiomyopathy MESH:C563384
1400 626-636 Disease denotes leukopenia MESH:D007970
1401 767-775 Disease denotes toxicity MESH:D064420
1402 959-970 Disease denotes retinopathy MESH:D012164
1403 1166-1194 Disease denotes liver and kidney dysfunction MESH:D051437
1404 1290-1325 Disease denotes increased QTc interval prolongation MESH:D008133
1405 1329-1343 Disease denotes critically ill MESH:D016638
1406 1358-1366 Disease denotes COVID-19 MESH:C000657245
1407 1661-1683 Disease denotes atrioventricular block MESH:D054537
1408 1819-1827 Disease denotes headache MESH:D006261
1409 1832-1836 Disease denotes rash MESH:D005076
1410 1907-1915 Disease denotes COVID-19 MESH:C000657245
1411 2011-2020 Disease denotes pneumonia MESH:D011014
1412 2037-2045 Disease denotes COVID-19 MESH:C000657245
1413 2067-2083 Disease denotes QTc prolongation MESH:D008133
1414 2204-2212 Disease denotes COVID-19 MESH:C000657245
1415 2735-2757 Disease denotes ventricular arrhythmia MESH:D001145
1416 2774-2782 Disease denotes COVID-19 MESH:C000657245
1417 3150-3163 Disease denotes heart disease MESH:D006331
1418 3508-3559 Disease denotes glucose 6-phosphate dehydrogenase (G6PD) deficiency MESH:D005955
1419 3597-3613 Disease denotes hemolytic anemia MESH:D000743
1420 3678-3693 Disease denotes G6PD deficiency MESH:D005955
1421 3771-3786 Disease denotes G6PD deficiency MESH:D005955

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T239 0-2 Sentence denotes 6.
T240 4-10 Sentence denotes Safety
T241 11-106 Sentence denotes CQ/HCQ are basic medications for malaria with a long history of reliable safety records [3,62].
T242 107-227 Sentence denotes However, the therapeutic window of CQ is narrow, and the toxic dose is 3 times higher than the therapeutic dose [55,63].
T243 228-356 Sentence denotes The most common adverse effects of taking CQ are gastrointestinal discomforts, such as nausea, vomiting, diarrhea, and anorexia.
T244 357-428 Sentence denotes These symptoms are mild and can be controlled by reducing the dose [3].
T245 429-685 Sentence denotes However, long-term and high-dose CQ intake can cause irreversible damage to the ear, cardiovascular system, and blood system, such as neurological deafness, conduction disorder cardiomyopathy, and leukopenia, though these adverse effects are very rare [3].
T246 686-776 Sentence denotes Compared to CQ, HCQ has fewer adverse effects, which may be related to its lower toxicity.
T247 777-837 Sentence denotes In animal models, HCQ was about 40% less toxic than CQ [64].
T248 838-976 Sentence denotes Reportedly, only overdoses (average daily dose > 5.0 mg/kg) and long-time (more than 5 years) ingestion of HCQ can cause retinopathy [65].
T249 977-1154 Sentence denotes CQ/HCQ have similar pharmacokinetic characteristics, fast absorption in the gastrointestinal tract, fast excretion in liver and kidney, and a long half-life (40–50 days) [3,66].
T250 1155-1225 Sentence denotes Therefore, liver and kidney dysfunction may aggravate adverse effects.
T251 1226-1402 Sentence denotes High-dose CQ (600 mg/2 times/day for 10 day) is associated with increased QTc interval prolongation in critically ill patients with COVID-19 [49] and should not be recommended.
T252 1403-1550 Sentence denotes In the initial trial from France, of the 84 patients receiving HCQ treatment, 8 patients discontinued HCQ owing to ECG modifications within 4 days.
T253 1551-1703 Sentence denotes Among them, 7 patients had a prolonged QTc interval more than 60 ms, and one patient developed a first-degree atrioventricular block within 2 days [53].
T254 1704-1843 Sentence denotes In a randomized clinical trial from Wuhan, 2 out of 31 patients receiving HCQ treatment had minor adverse effects (headache and rash) [50].
T255 1844-1930 Sentence denotes Prolonged QT interval after taking HCQ may also develop in ICU COVID-19 patients [67].
T256 1931-2180 Sentence denotes A recent observation showed that patients who received HCQ for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation (19%), and concurrent use of azithromycin was associated with greater changes in QTc (21%) [68].
T257 2181-2599 Sentence denotes Another observation in COVID-19 patients admitted to ICU showed that QTc intervals increased in 93% of patients receiving HCQ with or without azithromycin, prolonged QTc was observed in 36% of patients after a duration of the treatment for 2 to 5 days, and 6 of 18 (33%) patients treated with HCQ and azithromycin and 1 of 22 (5%) of those treated with HCQ alone developed an increase in QTc of 500 ms or greater [69].
T258 2600-2797 Sentence denotes The use of CQ, CQ with a macrolide, HCQ and HCQ with a macrolide were all found to be independently associated with increased risk for ventricular arrhythmia in hospitalized COVID-19 patients [61].
T259 2798-2912 Sentence denotes Therefore, clinicians should carefully weigh risks and benefits if considering CQ/HCQ with or without a macrolide.
T260 2913-3085 Sentence denotes When CQ/HCQ are used, electrocardiogram examination should be routinely performed before taking the medicine, with close monitoring of QTc and concomitant medication usage.
T261 3086-3291 Sentence denotes CQ/HCQ should be more cautiously used in patients with existing heart disease, and the use of QT interval prolonging drugs, such as antiarrhythmic drugs, antihistamines, and moxifloxacin should be avoided.
T262 3292-3450 Sentence denotes In addition, close attention should be paid to symptoms after taking drugs and the drugs should be stopped in time if there are intolerable adverse reactions.
T263 3451-3619 Sentence denotes In addition, CQ is extremely dangerous for patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency because of the possible induction of hemolytic anemia [70].
T264 3620-3808 Sentence denotes Therefore, more caution should be given for patients with G6PD deficiency when CQ is considered for the treatment and the best way should be to detect G6PD deficiency before the use of CQ.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T25 315-331 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T26 333-341 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T27 347-355 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T28 576-584 Phenotype denotes deafness http://purl.obolibrary.org/obo/HP_0000365
T29 606-620 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T30 626-636 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T31 959-970 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T32 1580-1602 Phenotype denotes prolonged QTc interval http://purl.obolibrary.org/obo/HP_0005184
T33 1648-1683 Phenotype denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/HP_0011705
T34 1819-1827 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T35 1832-1836 Phenotype denotes rash http://purl.obolibrary.org/obo/HP_0000988
T36 1844-1865 Phenotype denotes Prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T37 2011-2020 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T38 2735-2757 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T39 3597-3613 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T1 3508-3515 http://rdf.glyconavi.org/CarTNa/CarTNa210/trivialname denotes glucose

2_test

Id Subject Object Predicate Lexical cue
32496926-25693996-132195705 100-101 25693996 denotes 3
32496926-20513543-132195706 102-104 20513543 denotes 62
32496926-7040501-132195707 223-225 7040501 denotes 63
32496926-25693996-132195708 425-426 25693996 denotes 3
32496926-25693996-132195709 682-683 25693996 denotes 3
32496926-6408923-132195710 833-835 6408923 denotes 64
32496926-30401979-132195711 972-974 30401979 denotes 65
32496926-25693996-132195712 1148-1149 25693996 denotes 3
32496926-22009248-132195713 1150-1152 22009248 denotes 66
32496926-31701865-132195714 3615-3617 31701865 denotes 70