PMC:7441788 / 3515-4209 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T11","span":{"begin":95,"end":99},"obj":"Body_part"},{"id":"T12","span":{"begin":459,"end":464},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T40","span":{"begin":86,"end":94},"obj":"Disease"},{"id":"T41","span":{"begin":484,"end":493},"obj":"Disease"},{"id":"T42","span":{"begin":574,"end":583},"obj":"Disease"}],"attributes":[{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0007256"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T25","span":{"begin":14,"end":22},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T26","span":{"begin":80,"end":85},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T27","span":{"begin":95,"end":104},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T28","span":{"begin":106,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0051864"},{"id":"T29","span":{"begin":452,"end":464},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T30","span":{"begin":509,"end":514},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T31","span":{"begin":639,"end":644},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T42","span":{"begin":4,"end":13},"obj":"Chemical"},{"id":"T43","span":{"begin":26,"end":28},"obj":"Chemical"},{"id":"T44","span":{"begin":301,"end":303},"obj":"Chemical"},{"id":"T45","span":{"begin":368,"end":370},"obj":"Chemical"},{"id":"T46","span":{"begin":446,"end":448},"obj":"Chemical"},{"id":"T47","span":{"begin":541,"end":543},"obj":"Chemical"},{"id":"T48","span":{"begin":619,"end":621},"obj":"Chemical"}],"attributes":[{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_90326"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T27","span":{"begin":26,"end":28},"obj":"Chemical"},{"id":"T28","span":{"begin":368,"end":370},"obj":"Chemical"},{"id":"T29","span":{"begin":446,"end":448},"obj":"Chemical"},{"id":"T30","span":{"begin":541,"end":543},"obj":"Chemical"},{"id":"T31","span":{"begin":619,"end":621},"obj":"Chemical"}],"attributes":[{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T37","span":{"begin":37,"end":45},"obj":"Species"},{"id":"T38","span":{"begin":50,"end":59},"obj":"Species"},{"id":"T39","span":{"begin":80,"end":85},"obj":"Species"},{"id":"T40","span":{"begin":406,"end":414},"obj":"Species"},{"id":"T41","span":{"begin":475,"end":483},"obj":"Species"},{"id":"T42","span":{"begin":565,"end":573},"obj":"Species"}],"attributes":[{"id":"A37","pred":"ncbi_taxonomy_id","subj":"T37","obj":"NCBItxid:1335626"},{"id":"A38","pred":"ncbi_taxonomy_id","subj":"T38","obj":"NCBItxid:11137"},{"id":"A39","pred":"ncbi_taxonomy_id","subj":"T39","obj":"NCBItxid:9606"},{"id":"A40","pred":"ncbi_taxonomy_id","subj":"T40","obj":"NCBItxid:1335626"},{"id":"A41","pred":"ncbi_taxonomy_id","subj":"T41","obj":"NCBItxid:1335626"},{"id":"A42","pred":"ncbi_taxonomy_id","subj":"T42","obj":"NCBItxid:1335626"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T32","span":{"begin":0,"end":367},"obj":"Sentence"},{"id":"T33","span":{"begin":368,"end":433},"obj":"Sentence"},{"id":"T34","span":{"begin":434,"end":526},"obj":"Sentence"},{"id":"T35","span":{"begin":527,"end":694},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"154","span":{"begin":200,"end":202},"obj":"Gene"},{"id":"155","span":{"begin":260,"end":262},"obj":"Gene"},{"id":"156","span":{"begin":598,"end":600},"obj":"Gene"},{"id":"157","span":{"begin":588,"end":590},"obj":"Gene"},{"id":"158","span":{"begin":183,"end":185},"obj":"Gene"},{"id":"159","span":{"begin":37,"end":45},"obj":"Species"},{"id":"160","span":{"begin":50,"end":59},"obj":"Species"},{"id":"161","span":{"begin":80,"end":85},"obj":"Species"},{"id":"162","span":{"begin":406,"end":414},"obj":"Species"},{"id":"163","span":{"begin":368,"end":370},"obj":"Chemical"},{"id":"164","span":{"begin":446,"end":448},"obj":"Chemical"},{"id":"165","span":{"begin":541,"end":543},"obj":"Chemical"},{"id":"166","span":{"begin":619,"end":621},"obj":"Chemical"},{"id":"167","span":{"begin":86,"end":94},"obj":"Disease"},{"id":"168","span":{"begin":475,"end":493},"obj":"Disease"},{"id":"169","span":{"begin":570,"end":583},"obj":"Disease"},{"id":"170","span":{"begin":106,"end":111},"obj":"CellLine"},{"id":"171","span":{"begin":452,"end":458},"obj":"CellLine"}],"attributes":[{"id":"A159","pred":"pubann:denotes","subj":"159","obj":"Tax:1335626"},{"id":"A164","pred":"pubann:denotes","subj":"164","obj":"MESH:D002738"},{"id":"A167","pred":"pubann:denotes","subj":"167","obj":"MESH:D006528"},{"id":"A154","pred":"pubann:denotes","subj":"154","obj":"Gene:56925"},{"id":"A158","pred":"pubann:denotes","subj":"158","obj":"Gene:56925"},{"id":"A160","pred":"pubann:denotes","subj":"160","obj":"Tax:11137"},{"id":"A157","pred":"pubann:denotes","subj":"157","obj":"Gene:56925"},{"id":"A161","pred":"pubann:denotes","subj":"161","obj":"Tax:9606"},{"id":"A156","pred":"pubann:denotes","subj":"156","obj":"Gene:56925"},{"id":"A168","pred":"pubann:denotes","subj":"168","obj":"MESH:D018352"},{"id":"A169","pred":"pubann:denotes","subj":"169","obj":"MESH:D018352"},{"id":"A171","pred":"pubann:denotes","subj":"171","obj":"CVCL:0574"},{"id":"A155","pred":"pubann:denotes","subj":"155","obj":"Gene:56925"},{"id":"A163","pred":"pubann:denotes","subj":"163","obj":"MESH:D002738"},{"id":"A170","pred":"pubann:denotes","subj":"170","obj":"CVCL:0336"},{"id":"A162","pred":"pubann:denotes","subj":"162","obj":"Tax:1335626"},{"id":"A165","pred":"pubann:denotes","subj":"165","obj":"MESH:D002738"},{"id":"A166","pred":"pubann:denotes","subj":"166","obj":"MESH:D002738"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T20","span":{"begin":4,"end":13},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"},{"id":"T21","span":{"begin":95,"end":99},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T22","span":{"begin":415,"end":426},"obj":"http://purl.obolibrary.org/obo/IDO_0000608"},{"id":"T23","span":{"begin":459,"end":464},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T24","span":{"begin":484,"end":493},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T25","span":{"begin":509,"end":514},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T26","span":{"begin":515,"end":525},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T27","span":{"begin":574,"end":583},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T28","span":{"begin":639,"end":644},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T29","span":{"begin":645,"end":655},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T11","span":{"begin":95,"end":99},"obj":"Body_part"},{"id":"T12","span":{"begin":459,"end":464},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T34","span":{"begin":86,"end":94},"obj":"Disease"},{"id":"T35","span":{"begin":484,"end":493},"obj":"Disease"},{"id":"T36","span":{"begin":574,"end":583},"obj":"Disease"}],"attributes":[{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0007256"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"154","span":{"begin":200,"end":202},"obj":"Gene"},{"id":"155","span":{"begin":260,"end":262},"obj":"Gene"},{"id":"156","span":{"begin":598,"end":600},"obj":"Gene"},{"id":"157","span":{"begin":588,"end":590},"obj":"Gene"},{"id":"158","span":{"begin":183,"end":185},"obj":"Gene"},{"id":"159","span":{"begin":37,"end":45},"obj":"Species"},{"id":"160","span":{"begin":50,"end":59},"obj":"Species"},{"id":"161","span":{"begin":80,"end":85},"obj":"Species"},{"id":"162","span":{"begin":406,"end":414},"obj":"Species"},{"id":"163","span":{"begin":368,"end":370},"obj":"Chemical"},{"id":"164","span":{"begin":446,"end":448},"obj":"Chemical"},{"id":"165","span":{"begin":541,"end":543},"obj":"Chemical"},{"id":"166","span":{"begin":619,"end":621},"obj":"Chemical"},{"id":"167","span":{"begin":86,"end":94},"obj":"Disease"},{"id":"168","span":{"begin":475,"end":493},"obj":"Disease"},{"id":"169","span":{"begin":570,"end":583},"obj":"Disease"},{"id":"170","span":{"begin":106,"end":111},"obj":"CellLine"},{"id":"171","span":{"begin":452,"end":458},"obj":"CellLine"}],"attributes":[{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"Gene:56925"},{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"Gene:56925"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Gene:56925"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Gene:56925"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"Gene:56925"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"Tax:1335626"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"Tax:11137"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"Tax:9606"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"Tax:1335626"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D002738"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"MESH:D002738"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"MESH:D002738"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"MESH:D002738"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"MESH:D006528"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"MESH:D018352"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"MESH:D018352"},{"id":"A170","pred":"tao:has_database_id","subj":"170","obj":"CVCL:0336"},{"id":"A171","pred":"tao:has_database_id","subj":"171","obj":"CVCL:0574"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T32","span":{"begin":0,"end":367},"obj":"Sentence"},{"id":"T33","span":{"begin":368,"end":433},"obj":"Sentence"},{"id":"T34","span":{"begin":434,"end":526},"obj":"Sentence"},{"id":"T35","span":{"begin":527,"end":694},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}

{"project":"2_test","denotations":[{"id":"32496926-24841269-132195655","span":{"begin":363,"end":365},"obj":"24841269"},{"id":"32496926-24841269-132195656","span":{"begin":690,"end":692},"obj":"24841269"}],"text":"The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and \u003e50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and \u003e15, respectively [10]. CQ could inhibit an early step in the MERS-CoV replication cycle. Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production. However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10]."}