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PMC:7441788 / 143-1685 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 239-248 Body_part denotes malarials http://purl.org/sig/ont/fma/fma46831
T2 421-429 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T3 0-24 Disease denotes Coronavirus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T4 26-34 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 47-94 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 47-80 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T7 96-104 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 187-195 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 335-343 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 600-608 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 713-721 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 884-892 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1137-1145 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1232-1240 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 1347-1355 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 1430-1438 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 467-475 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T2 513-521 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 576-577 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 610-611 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T5 833-834 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 1073-1074 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5 207-212 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T6 250-261 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T7 263-265 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T8 271-289 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T9 345-347 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T10 670-672 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T11 797-799 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T12 835-844 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T13 1036-1038 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T14 1075-1084 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T15 1209-1211 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T16 1323-1325 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T17 1405-1416 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T18 1420-1422 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T1 219-232 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigation http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T3 250-261 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T4 263-265 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T5 271-289 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T6 345-347 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T7 670-672 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T8 797-799 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T9 835-844 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T10 1036-1038 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T11 1075-1084 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T12 1209-1211 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T13 1323-1325 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T14 1420-1422 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T2 0-24 Species denotes Coronavirus Disease 2019 NCBItxid:2697049
T3 26-34 Species denotes COVID-19 NCBItxid:2697049
T4 47-94 Species denotes severe acute respiratory syndrome coronavirus 2 NCBItxid:2697049
T5 96-106 Species denotes SARS-CoV-2 NCBItxid:2697049
T6 187-195 Species denotes COVID-19 NCBItxid:2697049
T7 335-343 Species denotes COVID-19 NCBItxid:2697049
T8 600-608 Species denotes COVID-19 NCBItxid:2697049
T9 713-723 Species denotes SARS-CoV-2 NCBItxid:2697049
T10 884-892 Species denotes COVID-19 NCBItxid:2697049
T11 1137-1145 Species denotes COVID-19 NCBItxid:2697049
T12 1232-1240 Species denotes COVID-19 NCBItxid:2697049
T13 1347-1355 Species denotes COVID-19 NCBItxid:2697049
T14 1430-1438 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T7 0-132 Sentence denotes Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide.
T8 133-196 Sentence denotes Antiviral therapy is the most important treatment for COVID-19.
T9 197-344 Sentence denotes Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19.
T10 345-522 Sentence denotes CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity.
T11 523-609 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T12 610-759 Sentence denotes A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist.
T13 760-985 Sentence denotes Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects.
T14 986-1146 Sentence denotes However, recent studies indicated that the use of CQ/HCQ, alone or in combination with a macrolide, did not show any favorable effect on patients with COVID-19.
T15 1147-1250 Sentence denotes Adverse effects, including prolonged QT interval after taking CQ/HCQ, may develop in COVID-19 patients.
T16 1251-1542 Sentence denotes Therefore, current data are not sufficient enough to support the use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken about the application of CQ/HCQ in COVID-19 before conclusive findings are obtained by well-designed, multi-center, randomized, controlled studies.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
40 797-803 Gene denotes CQ/HCQ
41 47-94 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
42 96-106 Species denotes SARS-CoV-2 Tax:2697049
43 398-411 Species denotes coronaviruses Tax:11118
44 688-701 Species denotes coronaviruses Tax:11118
45 713-723 Species denotes SARS-CoV-2 Tax:2697049
46 1123-1131 Species denotes patients Tax:9606
47 1241-1249 Species denotes patients Tax:9606
48 250-261 Chemical denotes chloroquine MESH:D002738
49 263-265 Chemical denotes CQ MESH:D002738
50 271-289 Chemical denotes hydroxychloroquine MESH:D006886
51 291-294 Chemical denotes HCQ MESH:D006886
52 670-672 Chemical denotes CQ MESH:D002738
53 673-676 Chemical denotes HCQ MESH:D006886
54 835-844 Chemical denotes macrolide MESH:D018942
55 1036-1042 Chemical denotes CQ/HCQ
56 1075-1084 Chemical denotes macrolide MESH:D018942
57 1209-1211 Chemical denotes CQ MESH:D002738
58 1212-1215 Chemical denotes HCQ MESH:D006886
59 1323-1325 Chemical denotes CQ MESH:D002738
60 1326-1329 Chemical denotes HCQ MESH:D006886
61 1420-1422 Chemical denotes CQ MESH:D002738
62 1423-1426 Chemical denotes HCQ MESH:D006886
63 0-24 Disease denotes Coronavirus Disease 2019 MESH:C000657245
64 26-34 Disease denotes COVID-19 MESH:C000657245
65 187-195 Disease denotes COVID-19 MESH:C000657245
66 335-343 Disease denotes COVID-19 MESH:C000657245
67 600-608 Disease denotes COVID-19 MESH:C000657245
68 884-892 Disease denotes COVID-19 MESH:C000657245
69 924-937 Disease denotes delay disease MESH:D003141
70 1137-1145 Disease denotes COVID-19 MESH:C000657245
71 1232-1240 Disease denotes COVID-19 MESH:C000657245
72 1347-1355 Disease denotes COVID-19 MESH:C000657245
73 1430-1438 Disease denotes COVID-19 MESH:C000657245

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T1 12-19 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T2 133-142 http://purl.obolibrary.org/obo/IDO_0000559 denotes Antiviral
T3 872-880 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T4 930-937 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T1 239-248 Body_part denotes malarials http://purl.org/sig/ont/fma/fma46831
T2 421-429 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T1 430-443 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T2 467-482 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 0-24 Disease denotes Coronavirus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T3 26-34 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 47-94 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 96-106 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 187-195 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 335-343 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 600-608 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 713-723 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T10 884-892 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1137-1145 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1232-1240 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1347-1355 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1430-1438 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1174-1195 Phenotype denotes prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T1 430-443 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T2 467-482 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 430-443 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T2 467-482 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
40 797-803 Gene denotes CQ/HCQ
41 47-94 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
42 96-106 Species denotes SARS-CoV-2 Tax:2697049
43 398-411 Species denotes coronaviruses Tax:11118
44 688-701 Species denotes coronaviruses Tax:11118
45 713-723 Species denotes SARS-CoV-2 Tax:2697049
46 1123-1131 Species denotes patients Tax:9606
47 1241-1249 Species denotes patients Tax:9606
48 250-261 Chemical denotes chloroquine MESH:D002738
49 263-265 Chemical denotes CQ MESH:D002738
50 271-289 Chemical denotes hydroxychloroquine MESH:D006886
51 291-294 Chemical denotes HCQ MESH:D006886
52 670-672 Chemical denotes CQ MESH:D002738
53 673-676 Chemical denotes HCQ MESH:D006886
54 835-844 Chemical denotes macrolide MESH:D018942
55 1036-1042 Chemical denotes CQ/HCQ
56 1075-1084 Chemical denotes macrolide MESH:D018942
57 1209-1211 Chemical denotes CQ MESH:D002738
58 1212-1215 Chemical denotes HCQ MESH:D006886
59 1323-1325 Chemical denotes CQ MESH:D002738
60 1326-1329 Chemical denotes HCQ MESH:D006886
61 1420-1422 Chemical denotes CQ MESH:D002738
62 1423-1426 Chemical denotes HCQ MESH:D006886
63 0-24 Disease denotes Coronavirus Disease 2019 MESH:C000657245
64 26-34 Disease denotes COVID-19 MESH:C000657245
65 187-195 Disease denotes COVID-19 MESH:C000657245
66 335-343 Disease denotes COVID-19 MESH:C000657245
67 600-608 Disease denotes COVID-19 MESH:C000657245
68 884-892 Disease denotes COVID-19 MESH:C000657245
69 924-937 Disease denotes delay disease MESH:D003141
70 1137-1145 Disease denotes COVID-19 MESH:C000657245
71 1232-1240 Disease denotes COVID-19 MESH:C000657245
72 1347-1355 Disease denotes COVID-19 MESH:C000657245
73 1430-1438 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T7 0-132 Sentence denotes Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide.
T8 133-196 Sentence denotes Antiviral therapy is the most important treatment for COVID-19.
T9 197-344 Sentence denotes Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19.
T10 345-522 Sentence denotes CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity.
T11 523-609 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T12 610-759 Sentence denotes A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist.
T13 760-985 Sentence denotes Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects.
T14 986-1146 Sentence denotes However, recent studies indicated that the use of CQ/HCQ, alone or in combination with a macrolide, did not show any favorable effect on patients with COVID-19.
T15 1147-1250 Sentence denotes Adverse effects, including prolonged QT interval after taking CQ/HCQ, may develop in COVID-19 patients.
T16 1251-1542 Sentence denotes Therefore, current data are not sufficient enough to support the use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken about the application of CQ/HCQ in COVID-19 before conclusive findings are obtained by well-designed, multi-center, randomized, controlled studies.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1174-1195 Phenotype denotes prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657