PMC:7441788 / 129-760 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":253,"end":262},"obj":"Body_part"},{"id":"T2","span":{"begin":435,"end":443},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma46831"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67180"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T3","span":{"begin":14,"end":38},"obj":"Disease"},{"id":"T4","span":{"begin":40,"end":48},"obj":"Disease"},{"id":"T5","span":{"begin":61,"end":108},"obj":"Disease"},{"id":"T6","span":{"begin":61,"end":94},"obj":"Disease"},{"id":"T7","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"T8","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"T9","span":{"begin":349,"end":357},"obj":"Disease"},{"id":"T10","span":{"begin":614,"end":622},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":481,"end":489},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T2","span":{"begin":527,"end":535},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T3","span":{"begin":590,"end":591},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":624,"end":625},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T5","span":{"begin":221,"end":226},"obj":"Chemical"},{"id":"T6","span":{"begin":264,"end":275},"obj":"Chemical"},{"id":"T7","span":{"begin":277,"end":279},"obj":"Chemical"},{"id":"T8","span":{"begin":285,"end":303},"obj":"Chemical"},{"id":"T9","span":{"begin":359,"end":361},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T1","span":{"begin":233,"end":246},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A1","pred":"meddra_id","subj":"T1","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T3","span":{"begin":264,"end":275},"obj":"Chemical"},{"id":"T4","span":{"begin":277,"end":279},"obj":"Chemical"},{"id":"T5","span":{"begin":285,"end":303},"obj":"Chemical"},{"id":"T6","span":{"begin":359,"end":361},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T2","span":{"begin":14,"end":38},"obj":"Species"},{"id":"T3","span":{"begin":40,"end":48},"obj":"Species"},{"id":"T4","span":{"begin":61,"end":108},"obj":"Species"},{"id":"T5","span":{"begin":110,"end":120},"obj":"Species"},{"id":"T6","span":{"begin":201,"end":209},"obj":"Species"},{"id":"T7","span":{"begin":349,"end":357},"obj":"Species"},{"id":"T8","span":{"begin":614,"end":622},"obj":"Species"}],"attributes":[{"id":"A2","pred":"ncbi_taxonomy_id","subj":"T2","obj":"NCBItxid:2697049"},{"id":"A3","pred":"ncbi_taxonomy_id","subj":"T3","obj":"NCBItxid:2697049"},{"id":"A4","pred":"ncbi_taxonomy_id","subj":"T4","obj":"NCBItxid:2697049"},{"id":"A5","pred":"ncbi_taxonomy_id","subj":"T5","obj":"NCBItxid:2697049"},{"id":"A6","pred":"ncbi_taxonomy_id","subj":"T6","obj":"NCBItxid:2697049"},{"id":"A7","pred":"ncbi_taxonomy_id","subj":"T7","obj":"NCBItxid:2697049"},{"id":"A8","pred":"ncbi_taxonomy_id","subj":"T8","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T6","span":{"begin":5,"end":13},"obj":"Sentence"},{"id":"T7","span":{"begin":14,"end":146},"obj":"Sentence"},{"id":"T8","span":{"begin":147,"end":210},"obj":"Sentence"},{"id":"T9","span":{"begin":211,"end":358},"obj":"Sentence"},{"id":"T10","span":{"begin":359,"end":536},"obj":"Sentence"},{"id":"T11","span":{"begin":537,"end":623},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"41","span":{"begin":61,"end":108},"obj":"Species"},{"id":"42","span":{"begin":110,"end":120},"obj":"Species"},{"id":"43","span":{"begin":412,"end":425},"obj":"Species"},{"id":"48","span":{"begin":264,"end":275},"obj":"Chemical"},{"id":"49","span":{"begin":277,"end":279},"obj":"Chemical"},{"id":"50","span":{"begin":285,"end":303},"obj":"Chemical"},{"id":"51","span":{"begin":305,"end":308},"obj":"Chemical"},{"id":"63","span":{"begin":14,"end":38},"obj":"Disease"},{"id":"64","span":{"begin":40,"end":48},"obj":"Disease"},{"id":"65","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"66","span":{"begin":349,"end":357},"obj":"Disease"},{"id":"67","span":{"begin":614,"end":622},"obj":"Disease"}],"attributes":[{"id":"A49","pred":"pubann:denotes","subj":"49","obj":"MESH:D002738"},{"id":"A64","pred":"pubann:denotes","subj":"64","obj":"MESH:C000657245"},{"id":"A65","pred":"pubann:denotes","subj":"65","obj":"MESH:C000657245"},{"id":"A66","pred":"pubann:denotes","subj":"66","obj":"MESH:C000657245"},{"id":"A67","pred":"pubann:denotes","subj":"67","obj":"MESH:C000657245"},{"id":"A63","pred":"pubann:denotes","subj":"63","obj":"MESH:C000657245"},{"id":"A41","pred":"pubann:denotes","subj":"41","obj":"Tax:2697049"},{"id":"A50","pred":"pubann:denotes","subj":"50","obj":"MESH:D006886"},{"id":"A42","pred":"pubann:denotes","subj":"42","obj":"Tax:2697049"},{"id":"A51","pred":"pubann:denotes","subj":"51","obj":"MESH:D006886"},{"id":"A43","pred":"pubann:denotes","subj":"43","obj":"Tax:11118"},{"id":"A48","pred":"pubann:denotes","subj":"48","obj":"MESH:D002738"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T1","span":{"begin":26,"end":33},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"},{"id":"T2","span":{"begin":147,"end":156},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T1","span":{"begin":253,"end":262},"obj":"Body_part"},{"id":"T2","span":{"begin":435,"end":443},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma46831"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67180"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T1","span":{"begin":444,"end":457},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T2","span":{"begin":481,"end":496},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T2","span":{"begin":14,"end":38},"obj":"Disease"},{"id":"T3","span":{"begin":40,"end":48},"obj":"Disease"},{"id":"T4","span":{"begin":61,"end":108},"obj":"Disease"},{"id":"T5","span":{"begin":110,"end":120},"obj":"Disease"},{"id":"T6","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"T7","span":{"begin":349,"end":357},"obj":"Disease"},{"id":"T8","span":{"begin":614,"end":622},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T1","span":{"begin":444,"end":457},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T2","span":{"begin":481,"end":496},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":444,"end":457},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T2","span":{"begin":481,"end":496},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-PubTator","denotations":[{"id":"41","span":{"begin":61,"end":108},"obj":"Species"},{"id":"42","span":{"begin":110,"end":120},"obj":"Species"},{"id":"43","span":{"begin":412,"end":425},"obj":"Species"},{"id":"48","span":{"begin":264,"end":275},"obj":"Chemical"},{"id":"49","span":{"begin":277,"end":279},"obj":"Chemical"},{"id":"50","span":{"begin":285,"end":303},"obj":"Chemical"},{"id":"51","span":{"begin":305,"end":308},"obj":"Chemical"},{"id":"63","span":{"begin":14,"end":38},"obj":"Disease"},{"id":"64","span":{"begin":40,"end":48},"obj":"Disease"},{"id":"65","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"66","span":{"begin":349,"end":357},"obj":"Disease"},{"id":"67","span":{"begin":614,"end":622},"obj":"Disease"}],"attributes":[{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"Tax:2697049"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"Tax:2697049"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"Tax:11118"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"MESH:D002738"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:D002738"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"MESH:D006886"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"MESH:D006886"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"MESH:C000657245"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:C000657245"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"MESH:C000657245"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"MESH:C000657245"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}

{"project":"LitCovid-sentences","denotations":[{"id":"T6","span":{"begin":5,"end":13},"obj":"Sentence"},{"id":"T7","span":{"begin":14,"end":146},"obj":"Sentence"},{"id":"T8","span":{"begin":147,"end":210},"obj":"Sentence"},{"id":"T9","span":{"begin":211,"end":358},"obj":"Sentence"},{"id":"T10","span":{"begin":359,"end":536},"obj":"Sentence"},{"id":"T11","span":{"begin":537,"end":623},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ract\nABSTRACT\nCoronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A numbe"}