PMC:7441788 / 10133-10396 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T57","span":{"begin":63,"end":70},"obj":"Body_part"},{"id":"T58","span":{"begin":74,"end":86},"obj":"Body_part"}],"attributes":[{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T104","span":{"begin":234,"end":242},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T131","span":{"begin":63,"end":70},"obj":"Chemical"},{"id":"T132","span":{"begin":74,"end":86},"obj":"Chemical"},{"id":"T133","span":{"begin":93,"end":95},"obj":"Chemical"},{"id":"T134","span":{"begin":121,"end":128},"obj":"Chemical"},{"id":"T135","span":{"begin":179,"end":191},"obj":"Chemical"},{"id":"T136","span":{"begin":186,"end":191},"obj":"Chemical"},{"id":"T137","span":{"begin":246,"end":248},"obj":"Chemical"}],"attributes":[{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_36141"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T87","span":{"begin":63,"end":70},"obj":"Chemical"},{"id":"T88","span":{"begin":74,"end":86},"obj":"Chemical"},{"id":"T89","span":{"begin":93,"end":95},"obj":"Chemical"},{"id":"T90","span":{"begin":121,"end":128},"obj":"Chemical"},{"id":"T91","span":{"begin":179,"end":191},"obj":"Chemical"},{"id":"T92","span":{"begin":246,"end":248},"obj":"Chemical"}],"attributes":[{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A88","pred":"chebi_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_36141"},{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T75","span":{"begin":93,"end":200},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"395","span":{"begin":121,"end":140},"obj":"Gene"},{"id":"396","span":{"begin":142,"end":145},"obj":"Gene"},{"id":"402","span":{"begin":51,"end":58},"obj":"Species"},{"id":"403","span":{"begin":230,"end":233},"obj":"Species"},{"id":"410","span":{"begin":74,"end":86},"obj":"Chemical"},{"id":"411","span":{"begin":93,"end":95},"obj":"Chemical"},{"id":"412","span":{"begin":179,"end":191},"obj":"Chemical"},{"id":"413","span":{"begin":246,"end":248},"obj":"Chemical"},{"id":"414","span":{"begin":249,"end":252},"obj":"Chemical"}],"attributes":[{"id":"A413","pred":"pubann:denotes","subj":"413","obj":"MESH:D002738"},{"id":"A414","pred":"pubann:denotes","subj":"414","obj":"MESH:D006886"},{"id":"A410","pred":"pubann:denotes","subj":"410","obj":"MESH:D005732"},{"id":"A411","pred":"pubann:denotes","subj":"411","obj":"MESH:D002738"},{"id":"A395","pred":"pubann:denotes","subj":"395","obj":"Gene:4835"},{"id":"A396","pred":"pubann:denotes","subj":"396","obj":"Gene:4835"},{"id":"A402","pred":"pubann:denotes","subj":"402","obj":"Tax:694009"},{"id":"A412","pred":"pubann:denotes","subj":"412","obj":"MESH:D012794"},{"id":"A403","pred":"pubann:denotes","subj":"403","obj":"Tax:11118"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T418","span":{"begin":61,"end":70},"obj":"Protein"},{"id":"T451","span":{"begin":121,"end":140},"obj":"Protein"},{"id":"T457","span":{"begin":142,"end":145},"obj":"Protein"}],"attributes":[{"id":"A418","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9UIP0"},{"id":"A419","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9UIN9"},{"id":"A420","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9UIN8"},{"id":"A421","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9UIN7"},{"id":"A422","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9UIN6"},{"id":"A423","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9UBH8"},{"id":"A424","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NRH8"},{"id":"A425","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NRH7"},{"id":"A426","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NRH6"},{"id":"A427","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NRH5"},{"id":"A428","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NRH4"},{"id":"A429","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NPG5"},{"id":"A430","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NPE0"},{"id":"A431","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q9NP52"},{"id":"A432","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q95IF9"},{"id":"A433","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q8N5P3"},{"id":"A434","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q8IZU6"},{"id":"A435","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q8IZU5"},{"id":"A436","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q8IZU4"},{"id":"A437","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q86Z04"},{"id":"A438","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q7YR44"},{"id":"A439","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q7LA71"},{"id":"A440","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q7LA70"},{"id":"A441","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q5STD2"},{"id":"A442","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q5SQ85"},{"id":"A443","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q1XI16"},{"id":"A444","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q1XI12"},{"id":"A445","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/Q15517"},{"id":"A446","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/O43509"},{"id":"A447","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/O19084"},{"id":"A448","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/B0UYZ7"},{"id":"A449","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/B0S7V2"},{"id":"A450","pred":"uniprot_id","subj":"T418","obj":"https://www.uniprot.org/uniprot/A5A6L9"},{"id":"A451","pred":"uniprot_id","subj":"T451","obj":"https://www.uniprot.org/uniprot/Q9JI75"},{"id":"A452","pred":"uniprot_id","subj":"T451","obj":"https://www.uniprot.org/uniprot/Q6AY80"},{"id":"A453","pred":"uniprot_id","subj":"T451","obj":"https://www.uniprot.org/uniprot/Q5TD04"},{"id":"A454","pred":"uniprot_id","subj":"T451","obj":"https://www.uniprot.org/uniprot/Q5RBB9"},{"id":"A455","pred":"uniprot_id","subj":"T451","obj":"https://www.uniprot.org/uniprot/P16083"},{"id":"A456","pred":"uniprot_id","subj":"T451","obj":"https://www.uniprot.org/uniprot/B2R492"},{"id":"A457","pred":"uniprot_id","subj":"T457","obj":"https://www.uniprot.org/uniprot/Q9JI75"},{"id":"A458","pred":"uniprot_id","subj":"T457","obj":"https://www.uniprot.org/uniprot/Q6AY80"},{"id":"A459","pred":"uniprot_id","subj":"T457","obj":"https://www.uniprot.org/uniprot/Q5TD04"},{"id":"A460","pred":"uniprot_id","subj":"T457","obj":"https://www.uniprot.org/uniprot/Q5RBB9"},{"id":"A461","pred":"uniprot_id","subj":"T457","obj":"https://www.uniprot.org/uniprot/P16083"},{"id":"A462","pred":"uniprot_id","subj":"T457","obj":"https://www.uniprot.org/uniprot/B2R492"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T57","span":{"begin":63,"end":70},"obj":"Body_part"},{"id":"T58","span":{"begin":74,"end":86},"obj":"Body_part"}],"attributes":[{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T23","span":{"begin":163,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T22","span":{"begin":163,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T22","span":{"begin":163,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-PubTator","denotations":[{"id":"395","span":{"begin":121,"end":140},"obj":"Gene"},{"id":"396","span":{"begin":142,"end":145},"obj":"Gene"},{"id":"402","span":{"begin":51,"end":58},"obj":"Species"},{"id":"403","span":{"begin":230,"end":233},"obj":"Species"},{"id":"410","span":{"begin":74,"end":86},"obj":"Chemical"},{"id":"411","span":{"begin":93,"end":95},"obj":"Chemical"},{"id":"412","span":{"begin":179,"end":191},"obj":"Chemical"},{"id":"413","span":{"begin":246,"end":248},"obj":"Chemical"},{"id":"414","span":{"begin":249,"end":252},"obj":"Chemical"}],"attributes":[{"id":"A395","pred":"tao:has_database_id","subj":"395","obj":"Gene:4835"},{"id":"A396","pred":"tao:has_database_id","subj":"396","obj":"Gene:4835"},{"id":"A402","pred":"tao:has_database_id","subj":"402","obj":"Tax:694009"},{"id":"A403","pred":"tao:has_database_id","subj":"403","obj":"Tax:11118"},{"id":"A410","pred":"tao:has_database_id","subj":"410","obj":"MESH:D005732"},{"id":"A411","pred":"tao:has_database_id","subj":"411","obj":"MESH:D002738"},{"id":"A412","pred":"tao:has_database_id","subj":"412","obj":"MESH:D012794"},{"id":"A413","pred":"tao:has_database_id","subj":"413","obj":"MESH:D002738"},{"id":"A414","pred":"tao:has_database_id","subj":"414","obj":"MESH:D006886"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"LitCovid-sentences","denotations":[{"id":"T75","span":{"begin":93,"end":200},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}

{"project":"2_test","denotations":[{"id":"32496926-15078100-132195674","span":{"begin":193,"end":195},"obj":"15078100"},{"id":"32496926-9068613-132195675","span":{"begin":196,"end":198},"obj":"9068613"}],"text":"high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. Hence, the mechanism of anti-CoV activity of CQ/HCQ may also b"}