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PMC:7441777 / 47825-49511 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T98 286-294 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T99 385-393 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T100 545-553 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 629-636 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T102 719-727 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T103 932-935 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T104 1129-1137 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T74 955-963 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 1237-1240 Disease denotes pie http://purl.obolibrary.org/obo/MONDO_0000923
T76 1676-1679 Disease denotes pie http://purl.obolibrary.org/obo/MONDO_0000923

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T318 316-317 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T319 649-650 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 1110-1111 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T321 1386-1393 http://purl.obolibrary.org/obo/CLO_0001658 denotes actives
T322 1510-1511 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T323 1520-1521 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T666 49-59 Chemical denotes polyphenol http://purl.obolibrary.org/obo/CHEBI_26195
T667 135-146 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T668 181-189 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T669 260-277 Chemical denotes biomacromolecules http://purl.obolibrary.org/obo/CHEBI_33694
T670 286-294 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T671 358-369 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T672 385-393 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T673 481-492 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T674 545-553 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T675 629-636 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T676 663-671 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T677 719-727 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T678 740-744 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T679 758-761 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T680 767-777 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T681 862-873 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T682 1029-1040 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T683 1129-1137 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T684 1176-1180 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T685 1194-1197 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T686 1203-1213 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T687 1334-1336 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T688 1345-1347 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T689 1513-1517 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T690 1542-1545 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T691 1555-1565 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T37 629-644 http://purl.obolibrary.org/obo/GO_0006605 denotes protein targets
T38 932-947 http://purl.obolibrary.org/obo/GO_0039703 denotes RNA replication

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1447 49-59 Chemical denotes polyphenol MESH:D059808
1464 752-756 Gene denotes TF2b Gene:2959
1465 887-891 Gene denotes RdRp Gene:43740578
1466 1188-1192 Gene denotes TF2b Gene:2959
1467 1424-1426 Gene denotes S7 Gene:6264
1468 955-965 Species denotes SARS-CoV-2 Tax:2697049
1469 135-146 Chemical denotes polyphenols MESH:D059808
1470 181-189 Chemical denotes hydrogen MESH:D006859
1471 358-369 Chemical denotes polyphenols MESH:D059808
1472 481-492 Chemical denotes polyphenols MESH:D059808
1473 740-744 Chemical denotes EGCG MESH:C045651
1474 767-777 Chemical denotes remdesivir MESH:C000606551
1475 862-873 Chemical denotes polyphenols MESH:D059808
1476 1029-1040 Chemical denotes polyphenols MESH:D059808
1477 1176-1180 Chemical denotes EGCG MESH:C045651
1478 1203-1213 Chemical denotes remdesivir MESH:C000606551
1479 1338-1347 Disease denotes ChEMBL ID MESH:C537985
1484 1533-1537 Gene denotes TF2b Gene:2959
1485 1552-1553 Gene denotes E Gene:43740570
1486 1513-1517 Chemical denotes EGCG MESH:C045651
1487 1555-1565 Chemical denotes remdesivir MESH:C000606551

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T506 0-4 Sentence denotes 3.4.
T507 6-89 Sentence denotes Identification of target class for natural polyphenol via target prediction studies
T508 90-295 Sentence denotes The polyphenolic structural motif of dietary polyphenols allows them to serve as excellent hydrogen bond donors which in turn help them to strongly interact with various biomacromolecules such as proteins.
T509 296-426 Sentence denotes This interaction is a critical step in the regulatory role of polyphenols on various key proteins involved in cellular physiology.
T510 427-572 Sentence denotes The majority, if not all, of the beneficial effect of polyphenols, can be explained via the functional consequence of proteins it interacts with.
T511 573-672 Sentence denotes Molecular target studies help us to predict therapeutic protein targets for a given small molecule.
T512 673-778 Sentence denotes Herein, we analyzed the predicted interacting proteins/enzymes for EGCG, TF2a, TF2b, TF3, and remdesivir.
T513 779-966 Sentence denotes This study is particularly important in the current context as we think that these polyphenols could target RdRp, an important enzyme that catalyzes the RNA replication in the SARS-CoV-2.
T514 967-1146 Sentence denotes Notably, the molecular target analysis suggests that all four polyphenols possess excellent properties of druggability, and they interact with a diverse class of proteins/enzymes.
T515 1147-1269 Sentence denotes The top 25 target classes of EGCG, TF2a, TF2b, TF3, and remdesivir are represented in the pie-chart, as shown in Figure 8.
T516 1270-1464 Sentence denotes The detailed output table with the target, common name, UniProt ID, ChEMBL ID, target class, probability, and known actives in 2D/3D are listed in Tables S7–S11 in the Supplementary Information.
T517 1465-1474 Sentence denotes Figure 8.
T518 1476-1611 Sentence denotes Molecular target predictions for (A) EGCG, (B) TF2a, (C) TF2b (D) TF3, and (E) remdesivir obtained from swiss target prediction report.
T519 1612-1686 Sentence denotes The frequency of the target classes (top 25) is depicted in the pie chart.