PMC:7441777 / 41885-42740 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T57","span":{"begin":6,"end":11},"obj":"Body_part"},{"id":"T58","span":{"begin":29,"end":33},"obj":"Body_part"},{"id":"T59","span":{"begin":70,"end":80},"obj":"Body_part"},{"id":"T60","span":{"begin":334,"end":343},"obj":"Body_part"},{"id":"T61","span":{"begin":457,"end":469},"obj":"Body_part"},{"id":"T62","span":{"begin":473,"end":485},"obj":"Body_part"},{"id":"T63","span":{"begin":516,"end":523},"obj":"Body_part"},{"id":"T64","span":{"begin":566,"end":578},"obj":"Body_part"},{"id":"T65","span":{"begin":616,"end":628},"obj":"Body_part"},{"id":"T66","span":{"begin":675,"end":687},"obj":"Body_part"},{"id":"T67","span":{"begin":794,"end":806},"obj":"Body_part"}],"attributes":[{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma14543"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma62925"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T7","span":{"begin":6,"end":11},"obj":"Body_part"},{"id":"T8","span":{"begin":334,"end":343},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000160"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":6,"end":26},"obj":"Disease"},{"id":"T73","span":{"begin":12,"end":26},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0002271"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0004970"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T223","span":{"begin":0,"end":5},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T224","span":{"begin":6,"end":11},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"T225","span":{"begin":29,"end":38},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T226","span":{"begin":40,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0002172"},{"id":"T227","span":{"begin":40,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0051943"},{"id":"T228","span":{"begin":40,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0051958"},{"id":"T229","span":{"begin":40,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0051960"},{"id":"T230","span":{"begin":64,"end":69},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T231","span":{"begin":70,"end":80},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T232","span":{"begin":70,"end":80},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T233","span":{"begin":156,"end":157},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T234","span":{"begin":252,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0002172"},{"id":"T235","span":{"begin":252,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0051943"},{"id":"T236","span":{"begin":252,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0051958"},{"id":"T237","span":{"begin":252,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0051960"},{"id":"T238","span":{"begin":328,"end":333},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T239","span":{"begin":334,"end":343},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T240","span":{"begin":334,"end":343},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T241","span":{"begin":507,"end":515},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T242","span":{"begin":562,"end":565},"obj":"http://purl.obolibrary.org/obo/CLO_0001547"},{"id":"T243","span":{"begin":612,"end":615},"obj":"http://purl.obolibrary.org/obo/CLO_0001547"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T573","span":{"begin":158,"end":162},"obj":"Chemical"},{"id":"T574","span":{"begin":188,"end":192},"obj":"Chemical"},{"id":"T575","span":{"begin":206,"end":209},"obj":"Chemical"},{"id":"T576","span":{"begin":215,"end":225},"obj":"Chemical"},{"id":"T577","span":{"begin":371,"end":375},"obj":"Chemical"},{"id":"T578","span":{"begin":389,"end":392},"obj":"Chemical"},{"id":"T579","span":{"begin":398,"end":408},"obj":"Chemical"},{"id":"T580","span":{"begin":457,"end":469},"obj":"Chemical"},{"id":"T581","span":{"begin":473,"end":485},"obj":"Chemical"},{"id":"T582","span":{"begin":516,"end":523},"obj":"Chemical"},{"id":"T583","span":{"begin":534,"end":544},"obj":"Chemical"},{"id":"T584","span":{"begin":566,"end":578},"obj":"Chemical"},{"id":"T585","span":{"begin":581,"end":590},"obj":"Chemical"},{"id":"T586","span":{"begin":596,"end":600},"obj":"Chemical"},{"id":"T587","span":{"begin":605,"end":608},"obj":"Chemical"},{"id":"T588","span":{"begin":616,"end":628},"obj":"Chemical"},{"id":"T589","span":{"begin":629,"end":631},"obj":"Chemical"},{"id":"T590","span":{"begin":632,"end":641},"obj":"Chemical"},{"id":"T591","span":{"begin":675,"end":687},"obj":"Chemical"},{"id":"T592","span":{"begin":694,"end":696},"obj":"Chemical"},{"id":"T593","span":{"begin":697,"end":706},"obj":"Chemical"},{"id":"T594","span":{"begin":794,"end":806},"obj":"Chemical"},{"id":"T595","span":{"begin":818,"end":820},"obj":"Chemical"}],"attributes":[{"id":"A573","pred":"chebi_id","subj":"T573","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A574","pred":"chebi_id","subj":"T574","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A575","pred":"chebi_id","subj":"T575","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A576","pred":"chebi_id","subj":"T576","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A577","pred":"chebi_id","subj":"T577","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A578","pred":"chebi_id","subj":"T578","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A579","pred":"chebi_id","subj":"T579","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A580","pred":"chebi_id","subj":"T580","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A581","pred":"chebi_id","subj":"T581","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A582","pred":"chebi_id","subj":"T582","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A583","pred":"chebi_id","subj":"T583","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A584","pred":"chebi_id","subj":"T584","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A585","pred":"chebi_id","subj":"T585","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A586","pred":"chebi_id","subj":"T586","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A587","pred":"chebi_id","subj":"T587","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A588","pred":"chebi_id","subj":"T588","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A589","pred":"chebi_id","subj":"T589","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A590","pred":"chebi_id","subj":"T590","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A591","pred":"chebi_id","subj":"T591","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A592","pred":"chebi_id","subj":"T592","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A593","pred":"chebi_id","subj":"T593","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A594","pred":"chebi_id","subj":"T594","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A595","pred":"chebi_id","subj":"T595","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T17","span":{"begin":70,"end":91},"obj":"http://purl.obolibrary.org/obo/GO_0050892"},{"id":"T18","span":{"begin":471,"end":485},"obj":"http://purl.obolibrary.org/obo/GO_0008559"},{"id":"T19","span":{"begin":500,"end":506},"obj":"http://purl.obolibrary.org/obo/GO_0140352"},{"id":"T20","span":{"begin":500,"end":506},"obj":"http://purl.obolibrary.org/obo/GO_0140115"},{"id":"T21","span":{"begin":564,"end":578},"obj":"http://purl.obolibrary.org/obo/GO_0008559"},{"id":"T22","span":{"begin":614,"end":628},"obj":"http://purl.obolibrary.org/obo/GO_0008559"},{"id":"T23","span":{"begin":673,"end":687},"obj":"http://purl.obolibrary.org/obo/GO_0008559"},{"id":"T24","span":{"begin":792,"end":806},"obj":"http://purl.obolibrary.org/obo/GO_0008559"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1203","span":{"begin":200,"end":204},"obj":"Gene"},{"id":"1204","span":{"begin":383,"end":387},"obj":"Gene"},{"id":"1205","span":{"begin":471,"end":485},"obj":"Gene"},{"id":"1206","span":{"begin":564,"end":578},"obj":"Gene"},{"id":"1207","span":{"begin":660,"end":664},"obj":"Gene"},{"id":"1208","span":{"begin":792,"end":806},"obj":"Gene"},{"id":"1209","span":{"begin":507,"end":515},"obj":"Gene"},{"id":"1210","span":{"begin":0,"end":5},"obj":"Species"},{"id":"1211","span":{"begin":64,"end":69},"obj":"Species"},{"id":"1212","span":{"begin":328,"end":333},"obj":"Species"},{"id":"1213","span":{"begin":673,"end":687},"obj":"Gene"},{"id":"1214","span":{"begin":614,"end":628},"obj":"Gene"},{"id":"1215","span":{"begin":188,"end":192},"obj":"Chemical"},{"id":"1216","span":{"begin":215,"end":225},"obj":"Chemical"},{"id":"1217","span":{"begin":371,"end":375},"obj":"Chemical"},{"id":"1218","span":{"begin":398,"end":408},"obj":"Chemical"},{"id":"1219","span":{"begin":534,"end":544},"obj":"Chemical"},{"id":"1220","span":{"begin":596,"end":600},"obj":"Chemical"},{"id":"1221","span":{"begin":6,"end":26},"obj":"Disease"}],"attributes":[{"id":"A1203","pred":"tao:has_database_id","subj":"1203","obj":"Gene:2959"},{"id":"A1204","pred":"tao:has_database_id","subj":"1204","obj":"Gene:2959"},{"id":"A1205","pred":"tao:has_database_id","subj":"1205","obj":"Gene:5243"},{"id":"A1206","pred":"tao:has_database_id","subj":"1206","obj":"Gene:5243"},{"id":"A1207","pred":"tao:has_database_id","subj":"1207","obj":"Gene:2959"},{"id":"A1208","pred":"tao:has_database_id","subj":"1208","obj":"Gene:5243"},{"id":"A1209","pred":"tao:has_database_id","subj":"1209","obj":"Gene:43740571"},{"id":"A1210","pred":"tao:has_database_id","subj":"1210","obj":"Tax:9606"},{"id":"A1211","pred":"tao:has_database_id","subj":"1211","obj":"Tax:9606"},{"id":"A1212","pred":"tao:has_database_id","subj":"1212","obj":"Tax:9606"},{"id":"A1213","pred":"tao:has_database_id","subj":"1213","obj":"Gene:5243"},{"id":"A1214","pred":"tao:has_database_id","subj":"1214","obj":"Gene:5243"},{"id":"A1215","pred":"tao:has_database_id","subj":"1215","obj":"MESH:C045651"},{"id":"A1216","pred":"tao:has_database_id","subj":"1216","obj":"MESH:C000606551"},{"id":"A1217","pred":"tao:has_database_id","subj":"1217","obj":"MESH:C045651"},{"id":"A1218","pred":"tao:has_database_id","subj":"1218","obj":"MESH:C000606551"},{"id":"A1219","pred":"tao:has_database_id","subj":"1219","obj":"MESH:C000606551"},{"id":"A1220","pred":"tao:has_database_id","subj":"1220","obj":"MESH:C045651"},{"id":"A1221","pred":"tao:has_database_id","subj":"1221","obj":"MESH:D003110"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T423","span":{"begin":0,"end":163},"obj":"Sentence"},{"id":"T424","span":{"begin":164,"end":370},"obj":"Sentence"},{"id":"T425","span":{"begin":371,"end":524},"obj":"Sentence"},{"id":"T426","span":{"begin":525,"end":707},"obj":"Sentence"},{"id":"T427","span":{"begin":708,"end":855},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}

{"project":"2_test","denotations":[{"id":"32720577-23344793-56195132","span":{"begin":364,"end":368},"obj":"23344793"}],"text":"Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug. All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (\u003c8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu \u0026 Benet, 2013). EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein. However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor. Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information)."}