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PMC:7441777 / 41885-42740 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T57 6-11 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T58 29-33 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 70-80 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T60 334-343 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T61 457-469 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T62 473-485 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T63 516-523 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 566-578 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T65 616-628 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T66 675-687 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T67 794-806 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T7 6-11 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T8 334-343 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T72 6-26 Disease denotes colon adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002271
T73 12-26 Disease denotes adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004970

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T223 0-5 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T224 6-11 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T225 29-38 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T226 40-45 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco2
T227 40-45 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco2
T228 40-45 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco2
T229 40-45 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco2
T230 64-69 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T231 70-80 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T232 70-80 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T233 156-157 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 252-257 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco2
T235 252-257 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco2
T236 252-257 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco2
T237 252-257 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco2
T238 328-333 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T239 334-343 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T240 334-343 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T241 507-515 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T242 562-565 http://purl.obolibrary.org/obo/CLO_0001547 denotes a P
T243 612-615 http://purl.obolibrary.org/obo/CLO_0001547 denotes a P

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T573 158-162 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T574 188-192 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T575 206-209 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T576 215-225 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T577 371-375 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T578 389-392 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T579 398-408 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T580 457-469 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T581 473-485 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T582 516-523 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T583 534-544 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T584 566-578 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T585 581-590 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T586 596-600 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T587 605-608 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T588 616-628 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T589 629-631 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T590 632-641 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T591 675-687 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T592 694-696 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T593 697-706 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T594 794-806 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T595 818-820 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T17 70-91 http://purl.obolibrary.org/obo/GO_0050892 denotes intestinal absorption
T18 471-485 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T19 500-506 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T20 500-506 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T21 564-578 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T22 614-628 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T23 673-687 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T24 792-806 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1203 200-204 Gene denotes TF2b Gene:2959
1204 383-387 Gene denotes TF2b Gene:2959
1205 471-485 Gene denotes P-glycoprotein Gene:5243
1206 564-578 Gene denotes P-glycoprotein Gene:5243
1207 660-664 Gene denotes TF2b Gene:2959
1208 792-806 Gene denotes P-glycoprotein Gene:5243
1209 507-515 Gene denotes membrane Gene:43740571
1210 0-5 Species denotes Human Tax:9606
1211 64-69 Species denotes human Tax:9606
1212 328-333 Species denotes human Tax:9606
1213 673-687 Gene denotes P-glycoprotein Gene:5243
1214 614-628 Gene denotes P-glycoprotein Gene:5243
1215 188-192 Chemical denotes EGCG MESH:C045651
1216 215-225 Chemical denotes remdesivir MESH:C000606551
1217 371-375 Chemical denotes EGCG MESH:C045651
1218 398-408 Chemical denotes remdesivir MESH:C000606551
1219 534-544 Chemical denotes remdesivir MESH:C000606551
1220 596-600 Chemical denotes EGCG MESH:C045651
1221 6-26 Disease denotes colon adenocarcinoma MESH:D003110

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T423 0-163 Sentence denotes Human colon adenocarcinoma-2 cell line (Caco2) permeability and human intestinal absorption (HIA) are key parameters to decide the total bioavailability of a drug.
T424 164-370 Sentence denotes All the five compounds (EGCG, TF2a, TF2b, TF3, and remdesivir) showed comparatively low Caco2 permeability potential (<8 × 10−6 cm/s) and could be absorbed via the human intestine (Larregieu & Benet, 2013).
T425 371-524 Sentence denotes EGCG, TF2a, TF2b, TF3, and remdesivir were predicted to be substrates of permeability glycoprotein (P-glycoprotein), which is an efflux membrane protein.
T426 525-707 Sentence denotes However, remdesivir was predicted as a P-glycoprotein I inhibitor, and EGCG and TF3 as a P-glycoprotein II inhibitor, whereas TF2a and TF2b as both P-glycoprotein I and II inhibitor.
T427 708-855 Sentence denotes Hence, above mentioned five compounds could regulate the physiological functions of P-glycoprotein (see Table S3 in the Supplementary Information).

2_test

Id Subject Object Predicate Lexical cue
32720577-23344793-56195132 364-368 23344793 denotes 2013