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PMC:7441777 / 3568-5249 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T14 48-51 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T15 62-65 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T16 194-197 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T17 198-204 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T18 864-867 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T19 1156-1159 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T20 1619-1629 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T24 34-42 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 300-308 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 356-364 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 771-779 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 1046-1054 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 1057-1066 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 1187-1198 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T31 1187-1196 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T21 105-106 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 157-162 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T23 398-403 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T24 560-561 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 624-629 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T26 969-970 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 992-993 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 1092-1095 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T29 1160-1167 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T30 1199-1204 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T31 1211-1216 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T32 1285-1291 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T33 1398-1399 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 1498-1499 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T35 1571-1572 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T36 1593-1594 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 1675-1679 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T40 18-22 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T41 540-550 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T42 800-814 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T43 800-809 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T44 810-814 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T45 1018-1028 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T46 1126-1130 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T47 1376-1385 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T50 1400-1404 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T51 1619-1629 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
162 78-82 Gene denotes RdRp Gene:43740578
163 221-225 Gene denotes RdRp Gene:43740578
164 480-484 Gene denotes RdRp Gene:43740578
165 535-539 Gene denotes RdRp Gene:43740578
166 1087-1091 Gene denotes RdRp Gene:43740578
167 1300-1304 Gene denotes RdRp Gene:43740578
168 1426-1429 Gene denotes β16 Gene:28910
169 1471-1475 Gene denotes RdRp Gene:43740578
170 1418-1421 Gene denotes β15 Gene:28934
171 763-767 Gene denotes RdRp Gene:43740578
172 292-296 Gene denotes RdRp Gene:43740578
173 34-44 Species denotes SARS-CoV-2 Tax:2697049
174 237-250 Species denotes coronaviruses Tax:11118
175 300-308 Species denotes SARS-CoV Tax:694009
176 356-366 Species denotes SARS-CoV-2 Tax:2697049
177 398-403 Species denotes human Tax:9606
178 490-503 Species denotes coronaviruses Tax:11118
179 624-629 Species denotes human Tax:9606
180 771-781 Species denotes SARS-CoV-2 Tax:2697049
181 1187-1204 Species denotes hepatitis C virus Tax:11103
182 1206-1216 Species denotes zika virus Tax:64320
183 1220-1233 Species denotes coronaviruses Tax:11118
184 816-826 Chemical denotes Remdesivir MESH:C000606551
185 948-958 Chemical denotes Remdesivir MESH:C000606551
186 1376-1385 Chemical denotes aspartate MESH:D001224
187 1046-1066 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T33 0-220 Sentence denotes Another potential drug target for SARS-CoV-2 is RNA‐dependent RNA polymerase (RdRp) (Figure 1), which is a key component of the replication machinery of the virus to make multiple copies of the RNA genome (Elfiky 2020c).
T34 221-274 Sentence denotes RdRp in various coronaviruses are remarkably similar.
T35 275-367 Sentence denotes For example, the RdRp of SARS-CoV exhibits ∼97% sequence similarity with that of SARS-CoV-2.
T36 368-705 Sentence denotes More importantly, there is no human polymerase counterpart that resembles the sequence/structural homology with RdRp from coronaviruses, and hence, the development of RdRp inhibitors could be a potential therapeutic strategy without risk of crosstalk with human polymerases (Borgio et al., 2020; Subissi et al., 2014; Zhai et al., 2005).
T37 706-1086 Sentence denotes Very recently, Yin et al. reported the crystal structure RdRp of SARS-CoV-2 complexed with an antiviral drug, Remdesivir highlighting how the template-primer RNA is recognized by the polymerase enzyme and the chain elongation is inhibited by Remdesivir providing a basis for developing a wide range of effective inhibitors to overcome from SARS-CoV-2 infection (Yin et al., 2020).
T38 1087-1280 Sentence denotes RdRp has been found to be an effective drug target for several other RNA viruses, spanning from the hepatitis C virus, zika virus to coronaviruses (Elfiky, 2017, 2019; Ganesan & Barakat, 2017).
T39 1281-1445 Sentence denotes The active site of RdRp is highly conserved, and the catalytic domains contain two consecutive aspartate residues in a beta-turn joining β15 and β16 (Elfiky 2020c).
T40 1446-1681 Sentence denotes The general structure of RdRp consists of 7 motifs (A to G) among them inner channel of catalytic sites represented by motif A to C, and they play a crucial role during the nucleotide addition cycle (Jia & Gong, 2019; Wu & Gong, 2018).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 1187-1196 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

2_test

Id Subject Object Predicate Lexical cue
32720577-32399096-56195091 658-662 32399096 denotes 2020
32720577-25197083-56195092 680-684 25197083 denotes 2014
32720577-30324891-56195093 1249-1253 30324891 denotes 2019
32720577-28164720-56195094 1274-1278 28164720 denotes 2017
32720577-31507560-56195095 1658-1662 31507560 denotes 2019