PMC:7441777 / 18278-18758 JSONTXT

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T263","span":{"begin":61,"end":65},"obj":"Chemical"},{"id":"T264","span":{"begin":79,"end":82},"obj":"Chemical"},{"id":"T265","span":{"begin":88,"end":98},"obj":"Chemical"}],"attributes":[{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A265","pred":"chebi_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"}],"text":"2.4. ADMET studies\nThe in-silico pharmacological studies of EGCG, TF2a, TF2b, TF3, and remdesivir were predicted based on their ADMET profile. The ADMET studies (absorption, distribution, metabolism, elimination, and toxicity) were predicted using the pkCSM tool (http://biosig.unimelb.edu.au/pkcsm/prediction) (Pires et al., 2015). The canonical SMILE molecular structures of the above-mentioned compounds were retrieved from the PubChem database (www.pubchem.ncbi.nlm.nih.gov)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":189,"end":199},"obj":"http://purl.obolibrary.org/obo/GO_0008152"}],"text":"2.4. ADMET studies\nThe in-silico pharmacological studies of EGCG, TF2a, TF2b, TF3, and remdesivir were predicted based on their ADMET profile. The ADMET studies (absorption, distribution, metabolism, elimination, and toxicity) were predicted using the pkCSM tool (http://biosig.unimelb.edu.au/pkcsm/prediction) (Pires et al., 2015). The canonical SMILE molecular structures of the above-mentioned compounds were retrieved from the PubChem database (www.pubchem.ncbi.nlm.nih.gov)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"398","span":{"begin":73,"end":77},"obj":"Gene"},{"id":"399","span":{"begin":61,"end":65},"obj":"Chemical"},{"id":"400","span":{"begin":88,"end":98},"obj":"Chemical"},{"id":"401","span":{"begin":218,"end":226},"obj":"Disease"}],"attributes":[{"id":"A398","pred":"tao:has_database_id","subj":"398","obj":"Gene:2959"},{"id":"A399","pred":"tao:has_database_id","subj":"399","obj":"MESH:C045651"},{"id":"A400","pred":"tao:has_database_id","subj":"400","obj":"MESH:C000606551"},{"id":"A401","pred":"tao:has_database_id","subj":"401","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"2.4. ADMET studies\nThe in-silico pharmacological studies of EGCG, TF2a, TF2b, TF3, and remdesivir were predicted based on their ADMET profile. The ADMET studies (absorption, distribution, metabolism, elimination, and toxicity) were predicted using the pkCSM tool (http://biosig.unimelb.edu.au/pkcsm/prediction) (Pires et al., 2015). The canonical SMILE molecular structures of the above-mentioned compounds were retrieved from the PubChem database (www.pubchem.ncbi.nlm.nih.gov)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T181","span":{"begin":0,"end":4},"obj":"Sentence"},{"id":"T182","span":{"begin":6,"end":19},"obj":"Sentence"},{"id":"T183","span":{"begin":20,"end":143},"obj":"Sentence"},{"id":"T184","span":{"begin":144,"end":333},"obj":"Sentence"},{"id":"T185","span":{"begin":334,"end":480},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"2.4. ADMET studies\nThe in-silico pharmacological studies of EGCG, TF2a, TF2b, TF3, and remdesivir were predicted based on their ADMET profile. The ADMET studies (absorption, distribution, metabolism, elimination, and toxicity) were predicted using the pkCSM tool (http://biosig.unimelb.edu.au/pkcsm/prediction) (Pires et al., 2015). The canonical SMILE molecular structures of the above-mentioned compounds were retrieved from the PubChem database (www.pubchem.ncbi.nlm.nih.gov)."}

{"project":"2_test","denotations":[{"id":"32720577-25860834-56195124","span":{"begin":327,"end":331},"obj":"25860834"}],"text":"2.4. ADMET studies\nThe in-silico pharmacological studies of EGCG, TF2a, TF2b, TF3, and remdesivir were predicted based on their ADMET profile. The ADMET studies (absorption, distribution, metabolism, elimination, and toxicity) were predicted using the pkCSM tool (http://biosig.unimelb.edu.au/pkcsm/prediction) (Pires et al., 2015). The canonical SMILE molecular structures of the above-mentioned compounds were retrieved from the PubChem database (www.pubchem.ncbi.nlm.nih.gov)."}