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PMC:7435837 / 40283-45261 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T264 1153-1167 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T265 1417-1422 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T266 1452-1464 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T267 1469-1483 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T268 1724-1734 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T269 1819-1823 Body_part denotes head http://purl.org/sig/ont/fma/fma7154
T270 1912-1916 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T271 1986-1990 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T272 2052-2056 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T273 2087-2101 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T274 2174-2188 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T275 2407-2422 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T276 2426-2442 Body_part denotes oligosaccharides http://purl.org/sig/ont/fma/fma82742
T277 2464-2477 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T278 2530-2535 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T279 2543-2548 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T280 2579-2593 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T281 2611-2624 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T282 2705-2710 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T283 2761-2769 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T284 2771-2785 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T285 2988-2992 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T286 3061-3065 Body_part denotes GAGs http://purl.org/sig/ont/fma/fma63011
T287 3121-3125 Body_part denotes GAGs http://purl.org/sig/ont/fma/fma63011
T288 3698-3705 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T289 3706-3720 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T290 3761-3776 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T291 3897-3912 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T292 4487-4501 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T293 4790-4805 Body_part denotes Polysaccharides http://purl.org/sig/ont/fma/fma82746

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T23 1819-1823 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T24 2611-2624 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T60 216-224 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 527-537 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T62 617-633 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T63 2825-2834 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64 4911-4921 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T375 31-39 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Humanity
T376 43-48 http://purl.obolibrary.org/obo/UBERON_0001456 denotes faced
T377 131-134 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T378 236-239 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T379 249-250 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T380 326-327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T381 351-359 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanity
T382 360-363 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T383 651-654 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T384 698-703 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T385 993-1000 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T386 1035-1042 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T387 1417-1422 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T388 1427-1434 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T389 1634-1639 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T390 1649-1657 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T391 1658-1661 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T392 1724-1729 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T393 1738-1739 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T394 1819-1823 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
T395 1819-1823 http://www.ebi.ac.uk/efo/EFO_0000964 denotes head
T396 1992-1993 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T397 2041-2046 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T398 2052-2056 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T399 2252-2259 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T400 2288-2296 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T401 2481-2482 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T402 2521-2522 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T403 2528-2535 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cells
T404 2543-2553 http://purl.obolibrary.org/obo/GO_0005623 denotes cells will
T405 2598-2606 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T406 2611-2624 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T407 2655-2662 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T408 2705-2715 http://purl.obolibrary.org/obo/GO_0005623 denotes cells will
T409 2737-2743 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T410 2816-2817 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T411 2964-2971 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T412 3271-3272 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T413 3388-3389 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T414 3629-3638 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T415 3629-3638 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T416 3962-3968 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T417 4265-4266 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T418 4595-4598 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T419 4624-4625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T420 4646-4647 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T421 4725-4730 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T520 492-502 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T521 869-878 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T522 1143-1152 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T523 1153-1167 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T524 1188-1193 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T525 1452-1464 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T526 1469-1483 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T527 1762-1766 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T528 1780-1784 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T529 2087-2101 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T530 2174-2188 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T531 2195-2200 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T532 2407-2422 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T533 2426-2442 Chemical denotes oligosaccharides http://purl.obolibrary.org/obo/CHEBI_50699
T534 2464-2477 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T535 2568-2578 Chemical denotes xenobiotic http://purl.obolibrary.org/obo/CHEBI_35703
T536 2579-2593 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T537 2753-2760 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T538 2771-2785 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T539 3061-3065 Chemical denotes GAGs http://purl.obolibrary.org/obo/CHEBI_18085
T540 3102-3111 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T541 3121-3125 Chemical denotes GAGs http://purl.obolibrary.org/obo/CHEBI_18085
T542 3416-3425 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T543 3534-3543 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T544 3698-3705 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T545 3706-3720 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T546 3761-3776 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T547 3788-3797 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T548 3897-3912 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T549 4425-4435 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T550 4466-4475 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T551 4487-4501 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T552 4674-4683 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T553 4856-4865 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T31 617-633 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T32 728-736 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior
T33 1920-1931 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T34 2698-2704 http://purl.obolibrary.org/obo/GO_0007613 denotes memory

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
829 216-226 Species denotes SARS-CoV-2 Tax:2697049
833 698-703 Species denotes human Tax:9606
834 527-546 Disease denotes infectious diseases MESH:D003141
835 617-633 Disease denotes viral infections MESH:D001102
838 1063-1076 Species denotes coronaviruses Tax:11118
839 1153-1167 Chemical denotes polysaccharide MESH:D011134
841 1469-1483 Chemical denotes polysaccharide MESH:D011134
843 1724-1729 Species denotes human Tax:9606
845 2174-2188 Chemical denotes polysaccharide MESH:D011134
850 2407-2422 Chemical denotes polysaccharides MESH:D011134
851 2426-2442 Chemical denotes oligosaccharides MESH:D009844
852 2579-2593 Chemical denotes polysaccharide MESH:D011134
853 2825-2834 Disease denotes infection MESH:D007239
855 3706-3720 Chemical denotes polysaccharide MESH:D011134
865 3962-3968 Species denotes humans Tax:9606
866 4725-4730 Species denotes human Tax:9606
867 4741-4752 Species denotes coronavirus Tax:11118
868 3761-3776 Chemical denotes polysaccharides MESH:D011134
869 3897-3912 Chemical denotes polysaccharides MESH:D011134
870 4487-4501 Chemical denotes polysaccharide MESH:D011134
871 4502-4505 Chemical denotes LbL
872 4790-4805 Chemical denotes Polysaccharides MESH:D011134
873 4899-4921 Disease denotes coronavirus infections MESH:D018352

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T305 0-2 Sentence denotes 7.
T306 3-30 Sentence denotes Conclusions and Perspective
T307 31-80 Sentence denotes Humanity is faced with an unprecedented pandemic.
T308 81-202 Sentence denotes It is the best-documented pandemic that the world has seen and this makes it different from previous, historic pandemics.
T309 203-322 Sentence denotes However, the SARS-CoV-2 pandemic has elicited a concerted, world effort to attempt and curb the effect of the pandemic.
T310 323-479 Sentence denotes If a cynical view is taken, humanity has to realize that this will not be the last pandemic and that potentially worse pandemics will be seen in the future.
T311 480-634 Sentence denotes The cusp of antibiotic resistance against many infectious diseases is currently being reached, yet there are even fewer defenses against viral infections.
T312 635-850 Sentence denotes However, nature has provided an abundance of tools, which with human ingenuity and unselfish behavior, can contribute greatly to the prevention of pandemics or at least help to control the spread of these pandemics.
T313 851-1001 Sentence denotes Seen only from an antiviral perspective, many efforts that were launched against other microorganisms can also be effectively applied against viruses.
T314 1002-1101 Sentence denotes Significant research efforts are focused on the treatment of coronaviruses and these will continue.
T315 1102-1207 Sentence denotes Of special interest is the employment of antiviral polysaccharide to create virucidal drugs and vaccines.
T316 1208-1278 Sentence denotes These efforts are aimed primarily at in vivo situations and treatment.
T317 1279-1394 Sentence denotes It is suggested that many of the in vivo knowledge can be applied to ex vivo, the passive effort against pathogens.
T318 1395-1503 Sentence denotes It is known that host cells and viruses interact through glycoprotein and polysaccharide-based interactions.
T319 1504-1719 Sentence denotes Therefore, the pharmacological effort is attempting to disrupt these interactions or the cellular effects that are seen after the virus and host membrane has indeed merged and the viral mechanism is put into motion.
T320 1720-1827 Sentence denotes The human body is a harsh environment and drug delivery and drug development meet these challenges head-on.
T321 1828-1991 Sentence denotes These include, for example, resistance to absorption of therapeutic agents into the body or degradation of therapeutic agents once they are absorbed into the body.
T322 1992-2128 Sentence denotes A clever strategy that is being followed against virus-host cell interaction is to exploit the polysaccharide-lectin recognition system.
T323 2129-2260 Sentence denotes In vivo efforts have shown that administered polysaccharide-based drugs can serve effectively as decoy binding targets for viruses.
T324 2261-2353 Sentence denotes Thus, the interaction with membrane-seated viral recognition mechanisms can be circumvented.
T325 2354-2536 Sentence denotes Another approach is to induce immunity by presenting polysaccharides or oligosaccharides that represent viral glycoproteins of a specific, or numerous, pathogen(s) to B- and T-cells.
T326 2537-2682 Sentence denotes These cells will recognize the xenobiotic polysaccharide and activate the immune system cascade and recognize further viruses and eliminate them.
T327 2683-2835 Sentence denotes If successful, memory cells will be formed and become active when the antigen-antibody, polysaccharide-lectin, interaction occurs in a future infection.
T328 2836-2877 Sentence denotes Our suggestion is almost unsophisticated.
T329 2878-2993 Sentence denotes It is inferred that several surfaces and substrates can be exploited as nanotraps for viruses, outside of the body.
T330 2994-3120 Sentence denotes It might not be farfetched to suggest that the naturally occurring GAGs will be sufficient to gain positive antiviral results.
T331 3121-3243 Sentence denotes GAGs are naturally occurring and abundantly available and are suitable to LbL nanocoating in their crude, unrefined state.
T332 3244-3319 Sentence denotes It might seem obvious that a layer-by-layer nanocoating strategy will work.
T333 3320-3439 Sentence denotes However, literature and patent literature surveys have not revealed a significant effort toward antiviral nanocoatings.
T334 3440-3553 Sentence denotes From the abundant bactericidal reports, it can be deduced that the LbL technique will produce antiviral surfaces.
T335 3554-3734 Sentence denotes However, we foresee success because surface recognition mechanisms between organisms, hosts, and guests, rely on similar principles and that is protein-polysaccharide interactions.
T336 3735-3860 Sentence denotes It is known that numerous polysaccharides have shown antiviral properties and hold significant promise as therapeutic agents.
T337 3861-3993 Sentence denotes It is suggested to LbL-nanocoat the polysaccharides onto several environmental structures with which humans come into contact daily.
T338 3994-4287 Sentence denotes We are also optimistic enough to state that researchers in an industry can be successful in this effort since the technique of LbL nanocoating is straightforward, robust, and based on many types of intermolecular forces that can almost guarantee adhesion of materials to a surface of any kind.
T339 4288-4444 Sentence denotes Numerous examples of LbL nanocoating have been found and described that coat commonly encountered surfaces and produce antibacterial and antifungal actions.
T340 4445-4552 Sentence denotes Investigation of the antiviral effects of polysaccharide LbL coatings should be investigated and developed.
T341 4553-4720 Sentence denotes This is an aspect of LbL nanocoating that has not been investigated to a large extent and is a very lucrative option for antiviral research and industrial cooperation.
T342 4721-4789 Sentence denotes The human, airborne coronavirus are ideal targets for this endeavor.
T343 4790-4978 Sentence denotes Polysaccharides, in vivo or ex vivo, should be explored for their antiviral applications, especially against coronavirus infections that may be recurring or more frequent in our existence.