PMC:7426526 / 42963-44633 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7426526","sourcedb":"PMC","sourceid":"7426526","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7426526","text":"Table 8 Biomarkers of therapy-induced senescence (TIS).\nBiomarker References\nSenescence-associated beta-galactosidase (SA-β-Gal) (12, 14, 504, 505, 510, 516–520)\nP53 (14, 504, 520, 521) (507)*\nRetinoblastoma (RB) Protein (CDKN2A; Ser780phosphorylated RB protein; cyclin-dependent kinase (CDK) 4/6-retinoblastoma) (12, 14, 504, 519–521) (507)*\nP14 (human) P19 (mouse) (12, 509, 510, 514, 515, 519) (505, 507, 513)*\nP16 (INK4A; CDKN2) (12, 14, 509, 512, 515, 519, 522) (505, 507, 513, 514, 516)\nP21 (WAF1) (14, 509, 522) (505, 507, 513)*\nSenescence-associated heterochromatic foci (SAHF) (12, 509, 510, 515, 519) (505, 507, 513)\nHeterochromatin protein 1 (HP1) gamma (509, 516, 518)\nTelomere length (505)*\nDi- or tri-methylated lysine 9 of histone H3 (H3K9Me2/3) (505, 517, 518)\nHistone H2A variant (macroH2A) (505, 517, 518)\nLysosomal-beta-galactosidase (GLB1) (516)\nInhibition of growth (ING) family of proteins (ING−1,−2,−3,−4,−5) (523)\nSenescence-associated genes (SAGs) family: [18B (KIF18B), Citron kinase (CIT), Centrosomal protein 55 (CEP55), minichromosome maintenance complex component 5/7 (MCM), Cell division cycle 45 (CDC45), enhancer of zeste homolog 2 (EZH2)] (524)\nSenescence-associated secretory phenotype (SASP) (12, 14, 510, 519) (505, 507, 509, 522)\nSoluble TNF-receptor-II (11, 523)\nChemokine (C-C motif) receptor/ligand 2, (CCR2/CCL2); Monocyte chemoattractant protein 1 (MCP-1) axis (525)\nIL-1 (526)\nIL-6 (527–531)\nIL-8 (528, 531, 532) (526, 527)\nRegulated on activation, normal T cell expressed and secreted (RANTES) (533, 534)\nExamples of the most important biomarkers of TIS are listed. 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