PMC:7417788 / 69435-70098 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7417788","sourcedb":"PMC","sourceid":"7417788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7417788","text":"To assess the impact of aging in circulating immune cells, we selected the top 20 genes out of 60 common upregulated genes in all immune cells. Aging scores were estimated for all cells as the average of the scaled (Z-normalized) expression of the genes in the list. The score of aging for all immune cell types can be used to predict the effect of aging on single cells and cell subtype levels. Calculation of the scores was done as follows: the score of the aging gene set in the given cell-subset (named as X) was computed as the sum of all UMI for all the aging genes expressed in X cell, divided by the sum of all UMI expressed by X cell (Pont et al., 2019).","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1467","span":{"begin":24,"end":29},"obj":"GO:0007568"},{"id":"T1468","span":{"begin":33,"end":44},"obj":"CL:0000080"},{"id":"T1469","span":{"begin":45,"end":51},"obj":"UBERON:0002405;CL:0000738"},{"id":"T1470","span":{"begin":52,"end":57},"obj":"CL:0000738"},{"id":"T1471","span":{"begin":82,"end":87},"obj":"SO:0000704"},{"id":"T1472","span":{"begin":117,"end":122},"obj":"SO:0000704"},{"id":"T1473","span":{"begin":130,"end":136},"obj":"UBERON:0002405;CL:0000738"},{"id":"T1474","span":{"begin":137,"end":142},"obj":"CL:0000738"},{"id":"T1475","span":{"begin":144,"end":149},"obj":"GO:0007568"},{"id":"T1476","span":{"begin":230,"end":240},"obj":"GO:0010467"},{"id":"T1477","span":{"begin":248,"end":253},"obj":"SO:0000704"},{"id":"T1478","span":{"begin":280,"end":285},"obj":"GO:0007568"},{"id":"T1479","span":{"begin":294,"end":300},"obj":"UBERON:0002405;CL:0000738"},{"id":"T1480","span":{"begin":301,"end":305},"obj":"CL:0000738"},{"id":"T1481","span":{"begin":349,"end":354},"obj":"GO:0007568"},{"id":"T1482","span":{"begin":460,"end":465},"obj":"GO:0007568"},{"id":"T1483","span":{"begin":466,"end":470},"obj":"SO:0000704"},{"id":"T1484","span":{"begin":560,"end":565},"obj":"GO:0007568"},{"id":"T1485","span":{"begin":566,"end":571},"obj":"SO:0000704"},{"id":"T1486","span":{"begin":572,"end":581},"obj":"GO:0010467"},{"id":"T1487","span":{"begin":623,"end":632},"obj":"GO:0010467"}],"attributes":[{"subj":"T1467","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1468","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1469","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1470","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1471","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1472","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1473","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1474","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1475","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1476","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1477","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1478","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1479","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1480","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1481","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1482","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1483","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1484","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1485","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1486","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1487","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T496","span":{"begin":52,"end":57},"obj":"Body_part"},{"id":"T497","span":{"begin":137,"end":142},"obj":"Body_part"},{"id":"T498","span":{"begin":180,"end":185},"obj":"Body_part"},{"id":"T499","span":{"begin":301,"end":305},"obj":"Body_part"},{"id":"T500","span":{"begin":365,"end":370},"obj":"Body_part"},{"id":"T501","span":{"begin":375,"end":379},"obj":"Body_part"},{"id":"T502","span":{"begin":466,"end":470},"obj":"Body_part"},{"id":"T503","span":{"begin":488,"end":492},"obj":"Body_part"},{"id":"T504","span":{"begin":587,"end":591},"obj":"Body_part"},{"id":"T505","span":{"begin":638,"end":642},"obj":"Body_part"}],"attributes":[{"id":"A496","pred":"fma_id","subj":"T496","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A497","pred":"fma_id","subj":"T497","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A498","pred":"fma_id","subj":"T498","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A499","pred":"fma_id","subj":"T499","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A500","pred":"fma_id","subj":"T500","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A501","pred":"fma_id","subj":"T501","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A502","pred":"fma_id","subj":"T502","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A503","pred":"fma_id","subj":"T503","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A504","pred":"fma_id","subj":"T504","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A505","pred":"fma_id","subj":"T505","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T496","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T497","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T498","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T499","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T500","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T501","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T502","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T503","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T504","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T505","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1139","span":{"begin":52,"end":57},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1140","span":{"begin":82,"end":87},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T1141","span":{"begin":117,"end":122},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T1142","span":{"begin":137,"end":142},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1143","span":{"begin":180,"end":185},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1144","span":{"begin":248,"end":253},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T1145","span":{"begin":301,"end":311},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T1146","span":{"begin":365,"end":370},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1147","span":{"begin":375,"end":379},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1148","span":{"begin":466,"end":470},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T1149","span":{"begin":488,"end":492},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1150","span":{"begin":566,"end":571},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T1151","span":{"begin":587,"end":591},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1152","span":{"begin":638,"end":642},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T1139","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1140","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1141","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1142","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1143","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1144","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1145","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1146","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1147","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1148","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1149","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1150","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1151","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1152","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T303","span":{"begin":24,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T304","span":{"begin":144,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T305","span":{"begin":280,"end":285},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T306","span":{"begin":349,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T307","span":{"begin":460,"end":465},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T308","span":{"begin":560,"end":565},"obj":"http://purl.obolibrary.org/obo/GO_0007568"}],"attributes":[{"subj":"T303","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T304","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T305","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T306","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T307","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T308","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T389","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T390","span":{"begin":144,"end":266},"obj":"Sentence"},{"id":"T391","span":{"begin":267,"end":395},"obj":"Sentence"},{"id":"T392","span":{"begin":396,"end":663},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T389","pred":"source","obj":"LitCovid-sentences"},{"subj":"T390","pred":"source","obj":"LitCovid-sentences"},{"subj":"T391","pred":"source","obj":"LitCovid-sentences"},{"subj":"T392","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32780218-29891535-132718730","span":{"begin":657,"end":661},"obj":"29891535"}],"attributes":[{"subj":"32780218-29891535-132718730","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#ec93de","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecdf"},{"id":"LitCovid-PD-CLO","color":"#ecc593"},{"id":"LitCovid-PD-GO-BP","color":"#ab93ec"},{"id":"LitCovid-sentences","color":"#94ec93"},{"id":"2_test","color":"#ec93ae"}]}]}}