PMC:7417114 / 52139-52809 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7417114","sourcedb":"PMC","sourceid":"7417114","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7417114","text":"Sorafenib (Nexavar)\n(Bayer and Onyx Pharmaceuticals) High fat meal decreases bioavailability by 29%;\nmean relative bioavailability=38-49% for tablet form;\npeak plasma levels achieved 3 h after dosing;\nVd= 213 L (suggests potentially high tissue distribution despite a high level of plasma protein binding, likely due to high lipophilicity) (227) Metabolized mainly by hepatic CYP3A4; glucuronidation mediated by UGT1A9 400 mg (2x200 mg tablets) orally twice daily;\n99.5% binding (AAG, HSA) There have been several reported cases of sorafenib-induced interstitial lung disease (203); pulmonary toxicity in association with sorafenib has been reported to be uncommon 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