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PMC:7417114 / 52139-52809 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T262 160-166 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T263 238-244 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T264 282-288 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T265 289-296 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T266 563-567 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T79 238-244 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T80 563-567 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T505 485-488 Disease denotes HSA http://purl.obolibrary.org/obo/MONDO_0011848
T506 550-575 Disease denotes interstitial lung disease http://purl.obolibrary.org/obo/MONDO_0015925
T507 563-575 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T597 58-61 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T598 160-166 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T599 266-267 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T600 282-288 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T601 485-488 http://purl.obolibrary.org/obo/PR_000001932 denotes HSA
T602 563-567 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T603 563-567 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T604 577-580 http://purl.obolibrary.org/obo/CLO_0001180 denotes 203
T605 632-635 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T50571 11-18 Chemical denotes Nexavar http://purl.obolibrary.org/obo/CHEBI_50928
T37004 289-296 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T54174 480-483 Chemical denotes AAG http://purl.obolibrary.org/obo/CHEBI_73318
T30134 532-541 Chemical denotes sorafenib http://purl.obolibrary.org/obo/CHEBI_50924
T16018 622-631 Chemical denotes sorafenib http://purl.obolibrary.org/obo/CHEBI_50924

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1509 376-382 Gene denotes CYP3A4 Gene:1576
1510 412-418 Gene denotes UGT1A9 Gene:54600

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T147 550-575 Phenotype denotes interstitial lung disease http://purl.obolibrary.org/obo/HP_0006530

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T424 0-19 Sentence denotes Sorafenib (Nexavar)
T425 20-100 Sentence denotes (Bayer and Onyx Pharmaceuticals) High fat meal decreases bioavailability by 29%;
T426 101-154 Sentence denotes mean relative bioavailability=38-49% for tablet form;
T427 155-200 Sentence denotes peak plasma levels achieved 3 h after dosing;
T428 201-464 Sentence denotes Vd= 213 L (suggests potentially high tissue distribution despite a high level of plasma protein binding, likely due to high lipophilicity) (227) Metabolized mainly by hepatic CYP3A4; glucuronidation mediated by UGT1A9 400 mg (2x200 mg tablets) orally twice daily;
T429 465-670 Sentence denotes 99.5% binding (AAG, HSA) There have been several reported cases of sorafenib-induced interstitial lung disease (203); pulmonary toxicity in association with sorafenib has been reported to be uncommon (228)

2_test

Id Subject Object Predicate Lexical cue
32778962-21392074-84130740 341-344 21392074 denotes 227
32778962-20702754-84130741 577-580 20702754 denotes 203
32778962-22752255-84130742 666-669 22752255 denotes 228