PMC:7417114 / 45379-45909 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7417114","sourcedb":"PMC","sourceid":"7417114","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7417114","text":"Fedratinib (Inrebic)\n(Celgene) Not affected by high fat breakfast; 400mg oral dose: Cmax= 1804ng/mL, AUC= 26,870 ng/*h/mL\n(210);\nrapidly absorbed, peak plasma concentration after 3 h after dosing; exposure increased in a greater than dose-proportional manner;\nVd= 1770L Metabolized by CYP3A4, CYP2C19, flavin-containing monooxygenase 3;\nCYP3A4 inhibitor can increase exposure of tofacitinib in plasma 400 mg orally once daily; reduced dose for patients taking strong CYP3A inhibitors or with severe renal impairment;\n\u003e 92% 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