Fedratinib (Inrebic)
(Celgene) Not affected by high fat breakfast; 400mg oral dose: Cmax= 1804ng/mL, AUC= 26,870 ng/*h/mL
(210);
rapidly absorbed, peak plasma concentration after 3 h after dosing; exposure increased in a greater than dose-proportional manner;
Vd= 1770L Metabolized by CYP3A4, CYP2C19, flavin-containing monooxygenase 3;
CYP3A4 inhibitor can increase exposure of tofacitinib in plasma 400 mg orally once daily; reduced dose for patients taking strong CYP3A inhibitors or with severe renal impairment;
> 92% binding