PMC:7417114 / 43462-44373
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T226 | 185-191 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T227 | 691-697 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T228 | 698-706 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T229 | 736-742 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T230 | 743-751 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T231 | 809-813 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T58 | 780-796 | Body_part | denotes | Pleural effusion | http://purl.obolibrary.org/obo/UBERON_0000175 |
| T59 | 809-813 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T60 | 888-905 | Body_part | denotes | pleural effusions | http://purl.obolibrary.org/obo/UBERON_0000175 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T439 | 524-536 | Disease | denotes | blast crisis | http://purl.obolibrary.org/obo/MONDO_0006115 |
| T440 | 627-651 | Disease | denotes | chronic myeloid leukemia | http://purl.obolibrary.org/obo/MONDO_0011996 |
| T441 | 635-651 | Disease | denotes | myeloid leukemia | http://purl.obolibrary.org/obo/MONDO_0004643 |
| T442 | 643-651 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T517 | 185-191 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T518 | 311-314 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | Has |
| T519 | 670-672 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
| T520 | 685-690 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T521 | 691-697 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T522 | 730-735 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T523 | 736-742 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T524 | 780-796 | http://purl.obolibrary.org/obo/UBERON_0000175 | denotes | Pleural effusion |
| T525 | 809-813 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T526 | 809-813 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T527 | 888-905 | http://purl.obolibrary.org/obo/UBERON_0000175 | denotes | pleural effusions |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T391 | 0-9 | Chemical | denotes | Bosutinib | http://purl.obolibrary.org/obo/CHEBI_39112 |
| T392 | 83-92 | Chemical | denotes | bosutinib | http://purl.obolibrary.org/obo/CHEBI_39112 |
| T393 | 192-196 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T394 | 698-706 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T395 | 743-751 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T396 | 839-848 | Chemical | denotes | bosutinib | http://purl.obolibrary.org/obo/CHEBI_39112 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1480 | 369-374 | Gene | denotes | ABCB1 | Gene:5243 |
| 1481 | 398-404 | Gene | denotes | CYP3A4 | Gene:1576 |
| 1553 | 685-690 | Species | denotes | human | Tax:9606 |
| 1554 | 730-735 | Species | denotes | human | Tax:9606 |
| 1555 | 856-864 | Species | denotes | patients | Tax:9606 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T114 | 627-651 | Phenotype | denotes | chronic myeloid leukemia | http://purl.obolibrary.org/obo/HP_0005506 |
| T115 | 780-796 | Phenotype | denotes | Pleural effusion | http://purl.obolibrary.org/obo/HP_0002202 |
| T116 | 888-905 | Phenotype | denotes | pleural effusions | http://purl.obolibrary.org/obo/HP_0002202 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T340 | 0-19 | Sentence | denotes | Bosutinib (Bosulif) |
| T341 | 20-110 | Sentence | denotes | (Pfiizer) Food increases exposure; following 15 daily doses of bosutinib 500 mg with food: |
| T342 | 111-148 | Sentence | denotes | Cmax = 200 ng/mL; AUC = 3650 ng∙h/mL; |
| T343 | 149-281 | Sentence | denotes | compared to initial administration, plasma drug exposure did not increase significantly; following 15 daily doses 400 mg once daily: |
| T344 | 282-300 | Sentence | denotes | AUC =2235 ng*h/mL; |
| T345 | 301-310 | Sentence | denotes | Tmax=4 h; |
| T346 | 311-335 | Sentence | denotes | Has acceptable exposure; |
| T347 | 336-354 | Sentence | denotes | Vd= 6080 ± 1230 L; |
| T348 | 355-669 | Sentence | denotes | (substrate of ABCB1) Metabolized mainly by CYP3A4, which can increase AUC and Cmax 500 mg orally once daily (chronic myeloid leukmia (chronic and accelerated phases and blast crisis with resistance/intolerance to prior therapy)); 400 mg orally once daily (newly diagnosed chronic myeloid leukemia (chronic phase)); |
| T349 | 670-911 | Sentence | denotes | 94% binding to human plasma proteins in vitro; 96% bound to human plasma proteins in healthy subjects ex vivo Pleural effusion is the main lung toxicity associated with bosutinib; 8% of patients in one study developed pleural effusions (207) |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32778962-22371878-84130714 | 907-910 | 22371878 | denotes | 207 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2206 | 206-314 | CHEBI:23888;CHEBI:23888 | denotes | did not increase significantly; following 15 daily doses 400 mg once daily: AUC =2235 ng*h/mL; Tmax=4 h; Has |