PMC:7417114 / 18942-20510
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T90 | 104-116 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T91 | 168-177 | Body_part | denotes | endosomes | http://purl.org/sig/ont/fma/fma67180 |
| T92 | 431-436 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T93 | 494-500 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T94 | 582-588 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T95 | 634-640 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T96 | 681-688 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T97 | 732-736 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T98 | 1077-1082 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T99 | 1144-1149 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T100 | 1179-1188 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T149 | 20-29 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T150 | 33-41 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T151 | 217-235 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T152 | 226-235 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T153 | 967-975 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T154 | 978-987 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T155 | 995-1003 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T156 | 1015-1023 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T157 | 1097-1100 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
| T158 | 1137-1143 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T159 | 1257-1260 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
| T160 | 1313-1328 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T161 | 1319-1328 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T162 | 1448-1456 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T163 | 1459-1468 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T164 | 1553-1556 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T204 | 236-239 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T205 | 312-313 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T206 | 331-334 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T207 | 431-436 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T208 | 442-443 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T209 | 544-552 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T210 | 614-615 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T211 | 725-726 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T212 | 732-736 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T213 | 746-749 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T214 | 820-828 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T215 | 877-878 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T216 | 941-942 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T217 | 1077-1082 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T218 | 1144-1149 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T219 | 1231-1238 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T165 | 104-116 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T166 | 277-287 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T167 | 454-463 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T168 | 494-519 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T169 | 494-500 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T170 | 501-519 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T172 | 510-519 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T173 | 521-529 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T174 | 565-567 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T175 | 582-588 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T176 | 634-640 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T177 | 681-688 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T178 | 769-777 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T179 | 1097-1100 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
| T180 | 1257-1271 | Chemical | denotes | ABL inhibitors | http://purl.obolibrary.org/obo/CHEBI_76617 |
| T181 | 1257-1260 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
| T182 | 1261-1271 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T183 | 1553-1556 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 508 | 291-302 | Gene | denotes | cathepsin L | Gene:1514 |
| 509 | 605-612 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 510 | 832-839 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 511 | 1033-1037 | Gene | denotes | ACE2 | Gene:59272 |
| 512 | 1055-1062 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 513 | 1097-1100 | Gene | denotes | ABL | Gene:25 |
| 514 | 1198-1209 | Gene | denotes | cathepsin L | Gene:1514 |
| 515 | 1257-1260 | Gene | denotes | ABL | Gene:25 |
| 516 | 1283-1294 | Gene | denotes | cathepsin L | Gene:1514 |
| 517 | 1553-1556 | Gene | denotes | ABL | Gene:25 |
| 518 | 33-41 | Species | denotes | SARS-CoV | Tax:694009 |
| 519 | 667-678 | Species | denotes | coronavirus | Tax:694448 |
| 520 | 995-1005 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 521 | 1015-1023 | Species | denotes | SARS-CoV | Tax:694009 |
| 522 | 494-500 | Chemical | denotes | serine | MESH:D012694 |
| 523 | 582-588 | Chemical | denotes | serine | MESH:D012694 |
| 524 | 634-640 | Chemical | denotes | serine | MESH:D012694 |
| 525 | 769-777 | Chemical | denotes | imatinib | MESH:D000068877 |
| 526 | 20-29 | Disease | denotes | infection | MESH:D007239 |
| 527 | 217-235 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 528 | 967-987 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 529 | 1137-1143 | Disease | denotes | cancer | MESH:D009369 |
| 530 | 1313-1328 | Disease | denotes | viral infection | MESH:D001102 |
| 531 | 1448-1468 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T28 | 1137-1143 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T54 | 149-160 | http://purl.obolibrary.org/obo/GO_0006508 | denotes | proteolysis |
| T55 | 804-816 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
| T56 | 1162-1171 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T57 | 1313-1328 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T112 | 0-216 | Sentence | denotes | As discussed above, infection by SARS-CoV is the result of several steps, including receptor binding, S glycoprotein conformational alterations, and proteolysis within endosomes that is mediated by capthepsin L (30). |
| T113 | 217-308 | Sentence | denotes | SARS-CoV infection has been shown to be blocked by targeted inhibitors of cathepsin L (30). |
| T114 | 309-742 | Sentence | denotes | On a related note, it has been shown that complete inhibition of viral entry and replication can result from treatment of cells with a cathepsin inhibitor as well as treatment with the serine protease inhibitor, camostat, which blocks activity of the type II transmembrane serine protease (TTSP) TMPRSS2, a surface-expressed serine protease that cleaves the coronavirus S protein and is involved in viral entry into a host cell (31). |
| T115 | 743-845 | Sentence | denotes | It has been proposed that imatinib may inhibit the function, localization or activity of TMPRSS2 (29). |
| T116 | 846-1083 | Sentence | denotes | This suggests that this may be a promising drug:target match that could be further explored as a potential treatment for SARS-CoV-2 infection, since SARS-CoV-2 uses the SARS-CoV receptor ACE2 and the protease TMPRSS2 to enter host cells. |
| T117 | 1084-1220 | Sentence | denotes | In addition, ABL and ARG kinases have been found, in cancer cells, to promote secretion of the endosomal protease cathepsin L (30) (32). |
| T118 | 1221-1346 | Sentence | denotes | Thus, the testing of the ability of ABL inhibitors to inhibit cathepsin L in the context of viral infection may be warranted. |
| T119 | 1347-1568 | Sentence | denotes | It may generally be worthwhile to evaluate each of these targets with respect to what is known about SARS-CoV-2 infection and conduct further studies to elucidate potential therapeutic approaches involving ABL inhibition. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32778962-16081529-84130556 | 212-214 | 16081529 | denotes | 30 |
| 32778962-16081529-84130557 | 304-306 | 16081529 | denotes | 30 |
| 32778962-24027332-84130558 | 738-740 | 24027332 | denotes | 31 |
| 32778962-27466418-84130559 | 841-843 | 27466418 | denotes | 29 |
| 32778962-16081529-84130560 | 1211-1213 | 16081529 | denotes | 30 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T407 | 33-41 | SP_10 | denotes | SARS-CoV |
| T408 | 102-103 | PG_18 | denotes | S |
| T409 | 104-116 | PG_18;CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T410 | 149-160 | GO:0006508 | denotes | proteolysis |
| T411 | 168-177 | GO:0005768 | denotes | endosomes |
| T412 | 217-225 | SP_10 | denotes | SARS-CoV |
| T413 | 277-287 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T414 | 374-379 | NCBITaxon:10239;GO:0035376 | denotes | viral |
| T415 | 380-385 | GO:0035376 | denotes | entry |
| T416 | 390-401 | GO:0006260 | denotes | replication |
| T417 | 454-463 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
| T418 | 510-519 | CHEBI:64926;CHEBI:64926 | denotes | inhibitor |
| T419 | 568-581 | GO:0016020 | denotes | transmembrane |
| T420 | 605-612 | G_2;PR:000016456 | denotes | TMPRSS2 |
| T421 | 616-623 | GO:0009986 | denotes | surface |
| T422 | 624-633 | GO:0010467 | denotes | expressed |
| T423 | 655-662 | MOP:0000780 | denotes | cleaves |
| T424 | 667-678 | NCBITaxon:11118 | denotes | coronavirus |
| T425 | 679-688 | PG_1 | denotes | S protein |
| T426 | 708-713 | NCBITaxon:10239;GO:0035376 | denotes | viral |
| T427 | 714-719 | GO:0035376 | denotes | entry |
| T428 | 769-777 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T429 | 832-839 | G_2;PR:000016456 | denotes | TMPRSS2 |
| T430 | 889-893 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T431 | 967-977 | SP_7 | denotes | SARS-CoV-2 |
| T432 | 995-1005 | SP_7 | denotes | SARS-CoV-2 |
| T433 | 1015-1023 | SP_10 | denotes | SARS-CoV |
| T434 | 1033-1037 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T435 | 1055-1062 | G_2 | denotes | TMPRSS2 |
| T436 | 1179-1188 | GO:0005768 | denotes | endosomal |
| T437 | 1261-1271 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T438 | 1313-1318 | NCBITaxon:10239 | denotes | viral |
| T439 | 1448-1458 | SP_7 | denotes | SARS-CoV-2 |