PMC:7414629 / 2975-4611 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7414629","sourcedb":"PMC","sourceid":"7414629","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7414629","text":"A 56-year-old Caucasian woman with a medical history of mild arterial hypertension (valsartan 40 mg) and hypothyreosis (l-thyroxin 25 µg) suffers from a dry cough, mild fever and a general weakness. In the context of the COVID-19 pandemic, SARS-CoV-2 RT-PCR on nasopharyngeal swab was performed and tested positive. A quarantine at home was decreed. The presumed contact to an infected person has been 12 days before the first symptoms appeared. Seven days later, she noticed weakness of her limbs while climbing stairs and a tingling sensation in all fingertips and toes. She was admitted to our emergency department 3 days after the occurrence of these neurological symptoms. On physical examination, the patient was afebrile with blood pressure at 135/82 mmHg, heart rate of 110 beats/min, respiratory rate at 18/min, and oxygen saturation of 95% on room air. She was conscious and had no dyspnea at the time of hospitalization. The neurological examination showed no meningeal irritation signs or abnormalities in the cranial nerve status. The muscle strength examination showed paresis in four limbs with a Medical Research Council (MRC) scale of 4/5 in the proximal, 3/5 in the distal upper extremities, 4/5 in the proximal, and 3/5 in distal in the lower extremities. Deep tendon reflexes were generally absent and there were no signs of upper motor neuron disorder. There was a reduction in the vibration of the knees from 2/8 in the 128 Hz tuning fork test, and fine touch sensation was bilateral stocking shaped. There was no spine sensory level. Meningeal irritation signs and upper motor neuron disorder signs were 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