PMC:7408073 / 96643-97539 JSON TXT

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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T511","span":{"begin":602,"end":606},"obj":"Body_part"}],"attributes":[{"id":"A511","pred":"fma_id","subj":"T511","obj":"http://purl.org/sig/ont/fma/fma24728"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T193","span":{"begin":602,"end":606},"obj":"Body_part"}],"attributes":[{"id":"A193","pred":"uberon_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/UBERON_0001456"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

LitCovid-PubTator

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T546","span":{"begin":344,"end":351},"obj":"Disease"}],"attributes":[{"id":"A546","pred":"mondo_id","subj":"T546","obj":"http://purl.obolibrary.org/obo/MONDO_0005292"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1172","span":{"begin":71,"end":76},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1173","span":{"begin":95,"end":103},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T1174","span":{"begin":132,"end":137},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1175","span":{"begin":143,"end":149},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T1176","span":{"begin":173,"end":174},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T41156","span":{"begin":260,"end":265},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T1178","span":{"begin":292,"end":297},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1179","span":{"begin":302,"end":307},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T1180","span":{"begin":313,"end":321},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1181","span":{"begin":328,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T1182","span":{"begin":363,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T1183","span":{"begin":423,"end":428},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1184","span":{"begin":445,"end":448},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T1185","span":{"begin":499,"end":504},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1186","span":{"begin":541,"end":544},"obj":"http://purl.obolibrary.org/obo/CLO_0002096"},{"id":"T1187","span":{"begin":602,"end":606},"obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"id":"T1188","span":{"begin":664,"end":666},"obj":"http://purl.obolibrary.org/obo/CLO_0050475"},{"id":"T1189","span":{"begin":697,"end":700},"obj":"http://purl.obolibrary.org/obo/CLO_0002096"},{"id":"T1190","span":{"begin":749,"end":752},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T1191","span":{"begin":758,"end":764},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T1192","span":{"begin":776,"end":782},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1193","span":{"begin":786,"end":787},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T39924","span":{"begin":18,"end":27},"obj":"Chemical"},{"id":"T21519","span":{"begin":216,"end":234},"obj":"Chemical"},{"id":"T436","span":{"begin":224,"end":234},"obj":"Chemical"},{"id":"T33321","span":{"begin":521,"end":530},"obj":"Chemical"},{"id":"T438","span":{"begin":541,"end":544},"obj":"Chemical"},{"id":"T62485","span":{"begin":697,"end":700},"obj":"Chemical"},{"id":"T440","span":{"begin":738,"end":748},"obj":"Chemical"}],"attributes":[{"id":"A85453","pred":"chebi_id","subj":"T39924","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A21047","pred":"chebi_id","subj":"T21519","obj":"http://purl.obolibrary.org/obo/CHEBI_76932"},{"id":"A13388","pred":"chebi_id","subj":"T436","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A33581","pred":"chebi_id","subj":"T33321","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A33642","pred":"chebi_id","subj":"T438","obj":"http://purl.obolibrary.org/obo/CHEBI_15756"},{"id":"A60186","pred":"chebi_id","subj":"T62485","obj":"http://purl.obolibrary.org/obo/CHEBI_15756"},{"id":"A34857","pred":"chebi_id","subj":"T440","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T155","span":{"begin":143,"end":162},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T156","span":{"begin":150,"end":162},"obj":"http://purl.obolibrary.org/obo/GO_0009293"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T469","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"T470","span":{"begin":206,"end":352},"obj":"Sentence"},{"id":"T471","span":{"begin":353,"end":645},"obj":"Sentence"},{"id":"T472","span":{"begin":646,"end":896},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T160","span":{"begin":344,"end":351},"obj":"Phenotype"}],"attributes":[{"id":"A160","pred":"hp_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/HP_0002583"}],"text":"Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo. Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis. Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation. Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf)."}

PMC:7408073 / 96643-97539 JSONTXT

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PMC:7408073 / 96643-97539 JSON TXT