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PMC:7408073 / 96643-97539 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T511 602-606 Body_part denotes face http://purl.org/sig/ont/fma/fma24728

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T193 602-606 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3387 77-81 Gene denotes ACE2 Gene:59272
3388 211-215 Gene denotes ACE2 Gene:70008
3389 308-312 Gene denotes ACE2 Gene:70008
3390 505-509 Gene denotes ACE2 Gene:59272
3391 724-728 Gene denotes ACE2 Gene:59272
3392 688-691 Gene denotes MLN Gene:4295
3393 532-535 Gene denotes MLN Gene:4295
3394 138-142 Gene denotes MasR Gene:116511
3395 71-76 Species denotes human Tax:9606
3396 132-137 Species denotes human Tax:9606
3397 260-265 Species denotes mouse Tax:10090
3398 266-269 Species denotes rat Tax:10116
3399 292-297 Species denotes human Tax:9606
3400 302-307 Species denotes mouse Tax:10090
3401 328-333 Species denotes mouse Tax:10090
3402 363-368 Species denotes mouse Tax:10090
3403 369-372 Species denotes rat Tax:10116
3404 423-428 Species denotes human Tax:9606
3405 429-441 Species denotes participants Tax:9606
3406 499-504 Species denotes human Tax:9606
3407 776-782 Species denotes humans Tax:9606
3408 344-351 Disease denotes colitis MESH:D003092
3409 472-480 Disease denotes toxicity MESH:D064420

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T546 344-351 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1172 71-76 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1173 95-103 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T1174 132-137 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1175 143-149 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T1176 173-174 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41156 260-265 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1178 292-297 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1179 302-307 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1180 313-321 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1181 328-333 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1182 363-368 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1183 423-428 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1184 445-448 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1185 499-504 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1186 541-544 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T1187 602-606 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T1188 664-666 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T1189 697-700 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T1190 749-752 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1191 758-764 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T1192 776-782 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T1193 786-787 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T39924 18-27 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T21519 216-234 Chemical denotes pathway inhibitors http://purl.obolibrary.org/obo/CHEBI_76932
T436 224-234 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T33321 521-530 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T438 541-544 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T62485 697-700 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T440 738-748 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T155 143-162 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T156 150-162 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T469 0-205 Sentence denotes Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo.
T470 206-352 Sentence denotes Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis.
T471 353-645 Sentence denotes Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation.
T472 646-896 Sentence denotes Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T160 344-351 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583