PMC:7408073 / 64500-65337 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T403","span":{"begin":119,"end":128},"obj":"Body_part"},{"id":"T404","span":{"begin":430,"end":438},"obj":"Body_part"},{"id":"T405","span":{"begin":478,"end":486},"obj":"Body_part"},{"id":"T406","span":{"begin":535,"end":553},"obj":"Body_part"},{"id":"T407","span":{"begin":617,"end":625},"obj":"Body_part"}],"attributes":[{"id":"A403","pred":"fma_id","subj":"T403","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A404","pred":"fma_id","subj":"T404","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A405","pred":"fma_id","subj":"T405","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A406","pred":"fma_id","subj":"T406","obj":"http://purl.org/sig/ont/fma/fma84758"},{"id":"A407","pred":"fma_id","subj":"T407","obj":"http://purl.org/sig/ont/fma/fma62851"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2295","span":{"begin":317,"end":327},"obj":"Gene"},{"id":"2296","span":{"begin":191,"end":199},"obj":"Species"},{"id":"2297","span":{"begin":780,"end":788},"obj":"Species"},{"id":"2298","span":{"begin":14,"end":25},"obj":"Chemical"},{"id":"2299","span":{"begin":274,"end":278},"obj":"Chemical"},{"id":"2300","span":{"begin":353,"end":364},"obj":"Chemical"},{"id":"2301","span":{"begin":513,"end":517},"obj":"Chemical"},{"id":"2302","span":{"begin":693,"end":697},"obj":"Chemical"},{"id":"2303","span":{"begin":825,"end":836},"obj":"Chemical"},{"id":"2304","span":{"begin":182,"end":190},"obj":"Disease"},{"id":"2305","span":{"begin":396,"end":406},"obj":"Disease"},{"id":"2306","span":{"begin":742,"end":752},"obj":"Disease"},{"id":"2307","span":{"begin":771,"end":779},"obj":"Disease"}],"attributes":[{"id":"A2295","pred":"tao:has_database_id","subj":"2295","obj":"Gene:2244"},{"id":"A2296","pred":"tao:has_database_id","subj":"2296","obj":"Tax:9606"},{"id":"A2297","pred":"tao:has_database_id","subj":"2297","obj":"Tax:9606"},{"id":"A2298","pred":"tao:has_database_id","subj":"2298","obj":"MESH:D002738"},{"id":"A2300","pred":"tao:has_database_id","subj":"2300","obj":"MESH:D002738"},{"id":"A2303","pred":"tao:has_database_id","subj":"2303","obj":"MESH:D002738"},{"id":"A2304","pred":"tao:has_database_id","subj":"2304","obj":"MESH:C000657245"},{"id":"A2305","pred":"tao:has_database_id","subj":"2305","obj":"MESH:D013927"},{"id":"A2306","pred":"tao:has_database_id","subj":"2306","obj":"MESH:D013927"},{"id":"A2307","pred":"tao:has_database_id","subj":"2307","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T321","span":{"begin":182,"end":190},"obj":"Disease"},{"id":"T322","span":{"begin":771,"end":779},"obj":"Disease"}],"attributes":[{"id":"A321","pred":"mondo_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A322","pred":"mondo_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T804","span":{"begin":26,"end":29},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T805","span":{"begin":119,"end":128},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T806","span":{"begin":365,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T807","span":{"begin":407,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T808","span":{"begin":439,"end":449},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T809","span":{"begin":487,"end":497},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T810","span":{"begin":535,"end":553},"obj":"http://purl.obolibrary.org/obo/GO_0030141"},{"id":"T811","span":{"begin":554,"end":557},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T812","span":{"begin":605,"end":613},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T813","span":{"begin":790,"end":791},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6825","span":{"begin":14,"end":25},"obj":"Chemical"},{"id":"T177","span":{"begin":65,"end":69},"obj":"Chemical"},{"id":"T70735","span":{"begin":212,"end":216},"obj":"Chemical"},{"id":"T181","span":{"begin":231,"end":235},"obj":"Chemical"},{"id":"T183","span":{"begin":274,"end":277},"obj":"Chemical"},{"id":"T41696","span":{"begin":353,"end":364},"obj":"Chemical"},{"id":"T185","span":{"begin":513,"end":516},"obj":"Chemical"},{"id":"T99734","span":{"begin":693,"end":696},"obj":"Chemical"},{"id":"T86289","span":{"begin":825,"end":836},"obj":"Chemical"}],"attributes":[{"id":"A37537","pred":"chebi_id","subj":"T6825","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A37083","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A82397","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A14520","pred":"chebi_id","subj":"T70735","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A33575","pred":"chebi_id","subj":"T70735","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A69261","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A97089","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A34788","pred":"chebi_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A32938","pred":"chebi_id","subj":"T41696","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A15217","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A41586","pred":"chebi_id","subj":"T99734","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A65866","pred":"chebi_id","subj":"T86289","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T131","span":{"begin":65,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0071578"},{"id":"T132","span":{"begin":70,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T133","span":{"begin":70,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0098657"},{"id":"T134","span":{"begin":430,"end":449},"obj":"http://purl.obolibrary.org/obo/GO_0030168"},{"id":"T135","span":{"begin":478,"end":497},"obj":"http://purl.obolibrary.org/obo/GO_0030168"},{"id":"T136","span":{"begin":643,"end":652},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}

{"project":"LitCovid-sentences","denotations":[{"id":"T311","span":{"begin":0,"end":246},"obj":"Sentence"},{"id":"T312","span":{"begin":247,"end":456},"obj":"Sentence"},{"id":"T313","span":{"begin":457,"end":837},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}

{"project":"2_test","denotations":[{"id":"32708755-25271834-20678874","span":{"begin":130,"end":133},"obj":"25271834"},{"id":"32708755-30266430-20678875","span":{"begin":344,"end":346},"obj":"30266430"},{"id":"32708755-30316994-20678876","span":{"begin":451,"end":454},"obj":"30316994"},{"id":"32708755-31171812-20678877","span":{"begin":654,"end":657},"obj":"31171812"}],"text":"Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine."}