PMC:7408073 / 64500-65337
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T403 | 119-128 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
| T404 | 430-438 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T405 | 478-486 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T406 | 535-553 | Body_part | denotes | secretory granules | http://purl.org/sig/ont/fma/fma84758 |
| T407 | 617-625 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2295 | 317-327 | Gene | denotes | fibrinogen | Gene:2244 |
| 2296 | 191-199 | Species | denotes | patients | Tax:9606 |
| 2297 | 780-788 | Species | denotes | patients | Tax:9606 |
| 2298 | 14-25 | Chemical | denotes | chloroquine | MESH:D002738 |
| 2299 | 274-278 | Chemical | denotes | Zn2+ | |
| 2300 | 353-364 | Chemical | denotes | chloroquine | MESH:D002738 |
| 2301 | 513-517 | Chemical | denotes | Zn2+ | |
| 2302 | 693-697 | Chemical | denotes | Zn2+ | |
| 2303 | 825-836 | Chemical | denotes | chloroquine | MESH:D002738 |
| 2304 | 182-190 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 2305 | 396-406 | Disease | denotes | thrombotic | MESH:D013927 |
| 2306 | 742-752 | Disease | denotes | thrombotic | MESH:D013927 |
| 2307 | 771-779 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T321 | 182-190 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T322 | 771-779 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T804 | 26-29 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T805 | 119-128 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
| T806 | 365-368 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T807 | 407-415 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T808 | 439-449 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T809 | 487-497 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T810 | 535-553 | http://purl.obolibrary.org/obo/GO_0030141 | denotes | secretory granules |
| T811 | 554-557 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T812 | 605-613 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T813 | 790-791 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T6825 | 14-25 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T177 | 65-69 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T70735 | 212-216 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T181 | 231-235 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T183 | 274-277 | Chemical | denotes | Zn2 | http://purl.obolibrary.org/obo/CHEBI_37256 |
| T41696 | 353-364 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T185 | 513-516 | Chemical | denotes | Zn2 | http://purl.obolibrary.org/obo/CHEBI_37256 |
| T99734 | 693-696 | Chemical | denotes | Zn2 | http://purl.obolibrary.org/obo/CHEBI_37256 |
| T86289 | 825-836 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T131 | 65-76 | http://purl.obolibrary.org/obo/GO_0071578 | denotes | zinc uptake |
| T132 | 70-76 | http://purl.obolibrary.org/obo/GO_0098739 | denotes | uptake |
| T133 | 70-76 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
| T134 | 430-449 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet activation |
| T135 | 478-497 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet activation |
| T136 | 643-652 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T311 | 0-246 | Sentence | denotes | Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions. |
| T312 | 247-456 | Sentence | denotes | As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125]. |
| T313 | 457-837 | Sentence | denotes | To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32708755-25271834-20678874 | 130-133 | 25271834 | denotes | 124 |
| 32708755-30266430-20678875 | 344-346 | 30266430 | denotes | 91 |
| 32708755-30316994-20678876 | 451-454 | 30316994 | denotes | 125 |
| 32708755-31171812-20678877 | 654-657 | 31171812 | denotes | 126 |