PMC:7408073 / 61707-63261 JSON TXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T394","span":{"begin":437,"end":443},"obj":"Body_part"},{"id":"T395","span":{"begin":579,"end":585},"obj":"Body_part"},{"id":"T396","span":{"begin":655,"end":661},"obj":"Body_part"}],"attributes":[{"id":"A394","pred":"fma_id","subj":"T394","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A395","pred":"fma_id","subj":"T395","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A396","pred":"fma_id","subj":"T396","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE). In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79]. Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin. As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112]. Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123]. As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102]. For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage."}

LitCovid-PubTator

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T779","span":{"begin":240,"end":241},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T780","span":{"begin":259,"end":262},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T781","span":{"begin":301,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T782","span":{"begin":354,"end":357},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T783","span":{"begin":437,"end":443},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T784","span":{"begin":579,"end":585},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T785","span":{"begin":614,"end":615},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T786","span":{"begin":655,"end":661},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T787","span":{"begin":770,"end":779},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T788","span":{"begin":770,"end":779},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T789","span":{"begin":1123,"end":1133},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T790","span":{"begin":1158,"end":1161},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T791","span":{"begin":1228,"end":1231},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T792","span":{"begin":1356,"end":1359},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T793","span":{"begin":1415,"end":1416},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE). In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79]. Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin. As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112]. Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123]. As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102]. For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage."}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T125","span":{"begin":1260,"end":1266},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T126","span":{"begin":1268,"end":1288},"obj":"http://purl.obolibrary.org/obo/GO_0048666"}],"text":"Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE). In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79]. Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin. As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112]. Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123]. As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102]. For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T296","span":{"begin":0,"end":217},"obj":"Sentence"},{"id":"T297","span":{"begin":218,"end":315},"obj":"Sentence"},{"id":"T298","span":{"begin":316,"end":610},"obj":"Sentence"},{"id":"T299","span":{"begin":611,"end":723},"obj":"Sentence"},{"id":"T300","span":{"begin":724,"end":1031},"obj":"Sentence"},{"id":"T301","span":{"begin":1032,"end":1361},"obj":"Sentence"},{"id":"T302","span":{"begin":1362,"end":1554},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE). In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79]. Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin. As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112]. Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123]. As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102]. For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage."}

2_test

{"project":"2_test","denotations":[{"id":"32708755-20717537-20678870","span":{"begin":424,"end":427},"obj":"20717537"},{"id":"32708755-20717537-20678871","span":{"begin":1026,"end":1029},"obj":"20717537"},{"id":"32708755-20617034-20678872","span":{"begin":1356,"end":1359},"obj":"20617034"}],"text":"Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE). In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79]. Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin. As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112]. Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123]. As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102]. For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage."}